Results 191 to 200 of about 192,395 (356)

Microglia Mitochondria Support Neuronal Maturation via Metabolic and Transcriptional Reprogramming in Human 3D In Vitro Brain Model

Advanced Science, EarlyView.
xx xx. ABSTRACT Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by disrupted neuronal circuit maturation. Emerging evidence implicates microglial function and mitochondrial regulation as contributors to ASD‐associated biology, yet the mechanisms linking these processes to neuronal development remain poorly defined ...
Sydney P. Sterben, Charitha C. Anamala, Sahan B. S. Kansakar, Vaishnavi Koduri, Volha Liaudanskaya   +4 more
wiley   +1 more source

NHE1-Mediated Metabolic Reprogramming in Cancer. [PDF]

Metabolites
Al-Hamaly MA, Forester BR, Blackburn JS.
europepmc   +1 more source

Metabolic Control of Epigenetics and Its Role in CD8+ T Cell Differentiation and Function [PDF]

, 2019
Glauben, Rainer, Siegmund, Britta, Weidinger, Carl, Yerinde, Cansu   +3 more
core   +1 more source

Additional file 5: Table S4. of Knockout of Vdac1 activates hypoxia-inducible factor through reactive oxygen species generation and induces tumor growth by promoting metabolic reprogramming and inflammation

, 2015
M. Brahimi-Horn, Sandy Giuliano, Estelle Saland, Sandra Lacas-Gervais, Tatiana Sheiko, Joffrey Pelletier, Isabelle Lavallée Bourget, Frédéric Bost, Chloé C. Féral, Etienne Boulter, Michel Tauc, Mircea Ivan, Barbara Garmy-Susini, Alexandra Popa, Bernard Mari, Jean-Emmanuel Sarry, William Craigen, Jacques Pouysségur, Nathalie M. Mazure   +18 more
openalex   +1 more source

Engineered Mesenchymal Stem Cell–NK Cell Complexes for Spatially Targeted and Functionally Revitalized Cancer Immunotherapy

Advanced Science, EarlyView.
IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang, Bo Yin, Munaiwaier Sabier, Youlan Yang, Mengling Wu, Zhouping Zhao, Xuanzhi Luo, Yuehong Zhong, Xiuming Zhu, Jie Zhang, Jing Wang, Kai Chen, Fei Ruan, Wei Zhang, Zhimin Lu, Jiong Wang   +15 more
wiley   +1 more source

Hypoxic microenvironment in cancer: role in metabolic reprogramming. [PDF]

Front Oncol
Sureka N, Maheshwari R, Agravat A, Singhal S, Zaman S, Rishi B, Siraj F, Zaheer S, Misra A.   +8 more
europepmc   +1 more source

SOX2 induces LPCAT1 expression to promote cholesterol metabolic reprogramming-mediated invasion and metastasis in osteosarcoma

Linchao Zhu, Ying Sun
openalex   +1 more source

Prolonged Sleep Deprivation Induces a Reprogramming of Circadian Rhythmicity with the Hepatic Metabolic Transcriptomic Profile [PDF]

Shiyan Liu, K. Zhuo, Yiming Wang, Xiaomei Wang, Yingying Zhao   +4 more
openalex   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Editorial: Regulation of inflammation: metabolic reprogramming and posttranslational modification. [PDF]

Front Immunol
Jiang Z, Li T, Bian J, Huai W.
europepmc   +1 more source