Results 231 to 240 of about 109,926 (267)

Cardiac Metabolism, Reprogramming, and Diseases

Journal of Cardiovascular Translational Research, 2023
Cardiovascular diseases (CVD) account for the largest bulk of deaths worldwide, posing a massive burden on societies and the global healthcare system. Besides, the incidence and prevalence of these diseases are on the rise, demanding imminent action to revert this trend. Cardiovascular pathogenesis harbors a variety of molecular and cellular mechanisms
Haichang Wang, Min Shen, Xiaofei Shu, Baolin Guo, Tengfei Jia, Jiaxu Feng, Zuocheng Lu, Yanyan Chen, Jie Lin, Yue Liu, Jiye Zhang, Xuan Zhang, Dongdong Sun   +12 more
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Metabolic Reprogramming in Brain Tumors

Annual Review of Pathology: Mechanisms of Disease, 2017
Next-generation sequencing has substantially enhanced our understanding of the genetics of primary brain tumors by uncovering several novel driver genetic alterations. How many of these genetic modifications contribute to the pathogenesis of brain tumors is not well understood. An exciting paradigm emerging in cancer biology is that oncogenes actively
Sriram, Venneti, Craig B, Thompson
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Metabolic Reprogramming and Cancer

2021
Cancer cell metabolism reprograming has been investigated for many years. What started with the idea that cancer cells had respiratory deficiencies and survived by adapting to use the glycolytic pathway, is understood today as a complex and dynamic set of changes in metabolic pathways that are influenced by intrinsic (mutations, oncogene activity) and ...
Ana Paula Lepique, Enrique Boccardo, Flávia Sardela de Miranda   +2 more
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Reprogrammed metabolism and diet

2021
This chapter highlights the role of diet in cancer prevention and causation. It explores our understanding that some food constituents exert their cancer-relevant effects by their ability to regulate gene expression: a paradigm of how environmental factors work together with genes, rather than the concept of environment versus genes.
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Advanced Metabolic Reprogramming

This white paper presents the most advanced cancer termination matrix ever developed — a clinically deployable, AI-adaptable, and biotech-compatible kill-switch architecture. At its core lies a 71×45 high-dimensional therapeutic matrix, comprising over 3,000 mechanistic nodes and more than 5,000 total data entries.
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Arginine metabolism supports metabolic reprogramming in trained immunity

Journal of Leukocyte Biology
Abstract Trained immunity, also termed innate immune memory, is supported by the metabolic rewiring of innate immune cells, altering their bioenergetic profile and ultimately their functions. While amino acids such as arginine are known to possess immunomodulatory properties, their role in trained immunity remains largely unexplored ...
Merlo Pich, L., Ziogas, A., Ziogas, A., Ferreira, A.V., Sumpter, N.A., Sarlea, Andrei, Kostidis, S., Joosten, L.A.B., Netea, M.G.   +8 more
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Reprogramming Microbial Metabolic Pathways

2012
Contributors Part I: Emerging Methods for Redesigning Microorganisms 1. Towards Synthetic Gene Circuits with Enhancers: Biology's Multi-input Integrators Roee Amit 2. Elementary Mode Analysis: A Useful Metabolic Pathway Analysis Tool for Reprograming Microbial Metabolic Pathways Cong T. Trinh and R. Adam Thompson 3.
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Bile acids and the gut microbiota: metabolic interactions and impacts on disease

Nature Reviews Microbiology, 2022
Stephanie Collins, Andrew D Patterson
exaly  

Metabolic Reprogramming

2023
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Gut microbiota in human metabolic health and disease

Nature Reviews Microbiology, 2020
Yong Fan, Oluf Borbye Pedersen
exaly