Results 221 to 230 of about 192,395 (356)

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

Metabolic Reprogramming of Macrophages [PDF]

Journal of Biological Chemistry, 2014
Alex J. Freemerman, Amy R. Johnson, Gina N. Sacks, J. Justin Milner, Erin L. Kirk, Melissa A. Troester, Andrew N. Macintyre, Pankuri Goraksha-Hicks, Jeffery C. Rathmell, Liza Makowski   +9 more
openaire   +1 more source

BGN/MDK Axis in the Melanoma Tumor Microenvironment Strengthens Tumor Malignancy by Modulating Cancer Cells and Cancer‐Associated Fibroblasts Crosstalk

Advanced Science, EarlyView.
This study reveals that m6A regulators cooperatively upregulate BGN in melanoma, promoting malignancy. Within the tumor microenvironment, CAFs show highest BGN expression. The BGN/MDK axis mediates cancer‐stroma crosstalk, driving normal fibroblast (NF) activation and enhancing the pro‐tumor effect of CAFs, highlighting a promising therapeutic target ...
Hao‐ze Shi, Ming‐yang Wu, Jin‐quan Liu, Cuicui Tian, Li Ma, Xue‐mei Zhou, Ze‐Hao Sun, Zhi‐yong Xu, Run‐dong Zhang, Shan‐yuan Ye, Li‐ming Huang, Yan Wang, Jing‐shu Xiong, Wen‐bo Bu, Xian‐feng Cheng, Jian‐fang Sun, Hao Chen   +16 more
wiley   +1 more source

Reviewer #2 (Public review): PRMT1-Mediated Metabolic Reprogramming Promotes Leukemogenesis

Hairui Su, Yong Sun, Han Guo, Chiao-Wang Sun, Qiuying Chen, Szumam Liu, Anlun Li, Min Gao, Rui Zhao, Glen Raffel, Jian Jin, Cheng-Kui Qu, Michael Yu, Christopher A Klug, George Y Zheng, Scott Ballinger, Matthew Kutny, X Long Zheng, Zechen Chong, Chamara Senevirathne, Steve Gross, Yabing Chen, Minkui Luo, Xinyang Zhao   +23 more
openalex   +1 more source

NIBV Induces Incomplete Autophagy via AMPK‐TFEB, Causing Kidney Injury in Chicks

Advanced Science, EarlyView.
This study reveals that NIBV can inhibit the nuclear translocation of TFEB by suppressing the expression of AMPK, leading to the blockade of autophagolysosomal functions, in turn increasing NIBV replication and triggering severe kidney injury in chicks.
Cheng Huang, Yizhou Zeng, Yunfeng Chen, Zhengqing Li, Salma Mbarouk Omar, Shengwei Zhong, Ping Liu, Zhanhong Zheng, Gaofeng Cai, Xiaona Gao, Xiaoquan Guo   +10 more
wiley   +1 more source

Lactylation modification - a bridge between sepsis and macrophage metabolic reprogramming. [PDF]

Front Immunol
Fang Z, Zhu GS, Nie DY, Xu B.
europepmc   +1 more source

Metabolic reprogramming sustains cancer cell survival following extracellular matrix detachment

, 2020
Hitoshi Endo, Satoshi Owada, Yutaka Inagaki, Yukari Shida, Masayuki Tatemichi   +4 more
openalex   +1 more source

Cuproptosis and Disulfidptosis Converge to Empower PD‐L1 Checkpoint Therapy via Cadict‐Induced PD‐L1 Translation

Advanced Science, EarlyView.
This study introduces Cadict, an EGFR‐targeted nanodrug that co‐delivers cuproptosis and disulfidptosis inducers to overcome immune resistance. Cadict synergistically enhances tumor cytotoxicity and sensitizes cancers to ICIs by upregulating PD‐L1 via an Eif5b‐dependent translation mechanism, fostering a potent antitumor immune response and ...
Shaoqing Huang, Shiyao Song, Xinhua Zhang, Jialing Gao, Ruihan Pu, Jiatong Dai, Xiaoxue Wu, Lulu Chen, Qinghai Li, Xiaoting Liu, Qi Zhou, Mei Song, Weiling He   +12 more
wiley   +1 more source

Genetically and metabolically corrected pluripotent stem cells from patients with mtDNA disease [PDF]

, 2015
Ahmed, Riffat, Amato, Paula, Belmonte, Juan Carlos Izpisua, Folmes, Clifford DL, Gutierrez, Nuria Marti, Hayama, Tomonari, Huang, Taosheng, Kang, Eunju, Koski, Amy, Laurent, Louise C, Lee, Yeonmi, Li, Ying, Ma, Hong, Ma, Li, Mitalipov, Nargiz, Mitalipov, Shoukhrat, Mora-Castilla, Sergio, Morey, Robert, Ocampo, Alejandro, Poulton, Joanna, Terzic, Andre, Tippner-Hedges, Rebecca, Van Dyken, Crystal, Wang, Xinjian, Wolf, Don P, Wu, Jun   +25 more
core   +1 more source

Dietary stress induced macrophage metabolic reprogramming, a determinant of animal growth [PDF]

Anusree Mahanta, Sajad Ahmad Najar, Nivedita Hariharan, Manisha Goyal, S. Ramaswamy, Angela Giangrande, Dasaradhi Palakodeti, Tina Mukherjee   +7 more
openalex   +1 more source