Results 221 to 230 of about 123,701 (265)

The controversial role of metabolic reprogramming in anti-tumor therapy resistance. [PDF]

Discov Oncol
Xu Y, Wang Y, Fu Q, Yao Y, Zhou Y.
europepmc   +1 more source

Covalent Reprogramming of Kinase Binders to Modulate Protein Abundance

Advanced Science, EarlyView.
Electrophilic remodeling of a broad‐spectrum kinase binder reveals how subtle chemical changes reprogram protein fate. An acrylamide analog of a multi‐kinase binder selectively stabilizes Aurora kinase A (AURKA) by suppressing its ubiquitination, while a short‐linker variant converts this stabilizer into a degrader.
Chen Mozes, Xiaokang Jin, Miguel A. Campos, Chen Zhou, Xiaoyu Zhang   +4 more
wiley   +1 more source

Palmitic Acid Promotes Antiviral Innate Immunity via ZDHHC20‐Mediated CMPK2 Palmitoylation

Advanced Science, EarlyView.
Metabolites have important functions in innate immune activation and regulation. Wang et al. uncover metabolic regulation of antiviral immunity through CMPK2 palmitoylation, which regulates CMPK2 mitochondrial localization and is promoted by ZDHHC20 but reversed by PPT1, inhibition of which antagonizes viral infection in mice.
Yujia Wang, Zenghui Cui, Yunkai Zhang, Zhiqing Li, Xuetao Cao   +4 more
wiley   +1 more source

Metabolic reprogramming of glutamine is associated with M2 macrophage polarization in allergic rhinitis. [PDF]

Front Immunol
Yan S, Xue K, Wang Y, Jia D, Chen Y, Lai X, Zhao C, Chen G, Xu Y, Wang X, Pan H, Zeng N.   +11 more
europepmc   +1 more source

The GATA1 N terminus coordinates metabolic reprogramming in erythropoiesis.

Blood
Ling T, Bezavada L, Mehmood R, Zhang K, Cotton A, Crawford JC, Jin H, Sona S, Li L, Ju Y, Han L, Liu N, Tran T, Vu HS, Jin Y, Zhai J, Pruett-Miller SM, Bhoopalan SV, Xu J, Ni M, Crispino JD.   +20 more
europepmc   +1 more source

Emerging roles of USP7 in tumor immune evasion, metabolic reprogramming, and therapeutic resistance. [PDF]

Front Immunol
Liu X, Zhu BC, Lian LL, Li YF.
europepmc   +1 more source

Elevated plasma cholesterol improves sepsis outcome by promoting hepatic metabolic reprogramming. [PDF]

Front Immunol
Wang Q, Xue J, Guo L, Hao D, Ito M, Reese R, Huang B, Wu C, Li XA.   +8 more
europepmc   +1 more source

Mitochondrial metabolic reprogramming, quality control, and intercellular transfer in regulating macrophage plasticity. [PDF]

Front Physiol
He G, Sun Q.
europepmc   +1 more source

Cancer IDO1-Mediated Tryptophan-Kynurenine Metabolic Reprogramming to Drive Skeletal Muscle Atrophy and Cachexia Acceleration. [PDF]

J Cachexia Sarcopenia Muscle
Han L, Jing L, Zhu X, Li C, Bai L, Fang Y, Zhou Y, Bai D, Lu J, Han Y, Guo C, Zhou S, Yang Q.   +12 more
europepmc   +1 more source