Results 231 to 240 of about 192,395 (356)

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Analyzation of Metabolic Reprogramming in Drug-Resistant MCF-7 Cells

, 2015
Derick Han, Ho Ching Leung, Andrew Vo
openalex   +1 more source

Figure S8 from Cancer-Associated Fibroblasts Promote Imatinib Resistance in Gastrointestinal Stromal Tumors through PGK1-Mediated Metabolic Reprogramming

Chao Li, Tianhong Teng, Xiaohan Lin, Xiangfei Sun, Tuo Yi, Hongshan Wang, Xiaodong Gao, Kuntang Shen   +7 more
openalex   +1 more source

Targeting receptor for activated C kinase 1 with a small molecule induces mitotic catastrophe and suppresses lipid metabolic reprogramming in hepatocellular carcinoma [PDF]

Longyan Wang, Peng Tan, Fei Wang, Huiming Huang, Xuejiao Wei, Zhuguo Wang, Xinyu Qiu, Yufeng Gao, Ruoxin Zhang, Pengfei Tu, Jun Li, Zhongdong Hu   +11 more
openalex   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Cardiac radiotherapy-induced epigenetic memory underlies electrophysiologic and metabolic reprogramming. [PDF]

J Clin Invest
Jordan SD, Fu S, Fulkerson A, Hu D, Ng S, Zhang DM, Manikandan S, Szymanski J, Hu N, Xie Y, Bedi A, Tabor J, Boggs-Bailey L, Strong L, Hicks S, Aryan L, Gabriel N, Hugo GD, Weng KC, Huebsch N, Schwarz JK, Zhang B, Rentschler SL.   +22 more
europepmc   +1 more source

Multi-Omics Analysis Reveals Signaling-Metabolic Reprogramming Crosstalk during Celastrol-Mediated Inflammatory Response

Guangshan Xie, Lin Zhu, Xin Diao, Xiuli Su, Zhong Li, Zongwei Cai   +5 more
openalex   +1 more source

Additional file 3 of Multi-scale comparative transcriptome analysis reveals key genes and metabolic reprogramming processes associated with oil palm fruit abscission

, 2021
Kim Fooyontphanich, Fabienne Morcillo, Thierry Joët, Stéphane Dussert, Julien Serret, Myriam Collin, Philippe Amblard, Sithichoke Tangphatsornruang, Peerapat Roongsattham, Chatchawan Jantasuriyarat, Jean-Luc Verdeil, Timothy J. Tranbarger   +11 more
openalex   +1 more source

Time‐Controlled Refrigerated Stem Cell Therapy Mitigates Scleroderma Fibrosis via Modulation of Mitochondrial Autophagy and Gut Metabolism

Advanced Science, EarlyView.
This study established an RT‐MSCs‐based therapeutic approach for scleroderma in mice. RT‐MSCs attenuated fibrosis by regulating mitochondrial autophagy and restored gut microbiota homeostasis. Metabolomic analyses confirmed recovery of key metabolites, and RT‐MSCs demonstrated favorable lesion targeting and safety profiles.
Xue Xia, Chenfei Kong, Xiaoming Zhao, Naixu Shi, Jinlan Jiang, Ping Li   +5 more
wiley   +1 more source

Metabolic reprogramming in cancer: signaling pathways and therapeutic targets. [PDF]

Mol Cancer
Dong S, Li T.
europepmc   +1 more source