Results 231 to 240 of about 123,701 (265)

Cardiac Metabolism, Reprogramming, and Diseases

Journal of Cardiovascular Translational Research, 2023
Cardiovascular diseases (CVD) account for the largest bulk of deaths worldwide, posing a massive burden on societies and the global healthcare system. Besides, the incidence and prevalence of these diseases are on the rise, demanding imminent action to revert this trend. Cardiovascular pathogenesis harbors a variety of molecular and cellular mechanisms
Haichang Wang   +12 more
openaire   +2 more sources

Myocardial Metabolic Reprogramming in HFpEF

Journal of Cardiovascular Translational Research, 2023
Heart failure (HF) caused by structural or functional cardiac abnormalities is a significant cause of morbidity and mortality worldwide. While HF with reduced ejection fraction (HErEF) is well understood, more than half of patients have HF with preserved ejection fraction (HFpEF).
Zihui Zhang   +5 more
openaire   +2 more sources

Metabolic Reprogramming and Longevity in Quiescence

Annual Review of Microbiology, 2022
Since Jacques Monod's foundational work in the 1940s, investigators studying bacterial physiology have largely (but not exclusively) focused on the exponential phase of bacterial cultures, which is characterized by rapid growth and high biosynthesis activity in the presence of excess nutrients.
Jonathan, Dworkin, Caroline S, Harwood
openaire   +2 more sources

Metabolic reprogramming of the tumour microenvironment

The FEBS Journal, 2015
Tumour cells, stromal cells and the stroma comprise the tumour microenvironment. The metabolism of both tumour cells and several types of tumour stromal cells, such as cancer‐associated fibroblasts and tumour‐associated macrophages, is reprogrammed. Current studies have found that stromal cells promote tumour progression and metastasis, through not ...
Yazhi, Xing   +3 more
openaire   +2 more sources

Metabolic Reprogramming in Brain Tumors

Annual Review of Pathology: Mechanisms of Disease, 2017
Next-generation sequencing has substantially enhanced our understanding of the genetics of primary brain tumors by uncovering several novel driver genetic alterations. How many of these genetic modifications contribute to the pathogenesis of brain tumors is not well understood. An exciting paradigm emerging in cancer biology is that oncogenes actively
Sriram, Venneti, Craig B, Thompson
openaire   +2 more sources

Reprogramming of Metabolism in Kidney Cancer

Seminars in Nephrology, 2020
Metabolic reprogramming is one of the major steps that tumor cells take during cancer progression. This process allows the cells to survive in a nutrient- and oxygen-deprived environment, to become stress tolerant, and to metastasize to different sites. Recent studies have shown that reprogramming happens in stromal cells and involves the cross-talk of
openaire   +2 more sources

Metabolic Reprogramming and Cancer

2021
Cancer cell metabolism reprograming has been investigated for many years. What started with the idea that cancer cells had respiratory deficiencies and survived by adapting to use the glycolytic pathway, is understood today as a complex and dynamic set of changes in metabolic pathways that are influenced by intrinsic (mutations, oncogene activity) and ...
Ana Paula Lepique   +2 more
openaire   +1 more source

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