Methionine enkephalin(MENK) upregulated memory T cells in anti-influenza response [PDF]
BMC Immunology, 2023 Novel prophylactic drugs and vaccination strategies for protection against influenza virus should induce specific effector T-cell immune responses in pulmonary airways and peripheral lymphoid organs.
Jing Tian +6 more
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Methionine Enkephalin Suppresses Osteocyte Apoptosis Induced by Compressive Force through Regulation of Nuclear Translocation of NFATc1 [PDF]
JBMR Plus, 2020 Mechanical stress stimulates bone remodeling, which occurs through bone formation and resorption, resulting in bone adaptation in response to the mechanical stress. Osteocytes perceive mechanical stress loaded to bones and promote bone remodeling through
Chisumi Sogi +14 more
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The novel mechanism of anticancer effect on gastric cancer through inducing G0/G1 cell cycle arrest and caspase-dependent apoptosis in vitro and in vivo by methionine enkephalin [PDF]
Cancer Management and Research, 2018 Xiaonan Wang,1 Jing Tian,1 Xue Jiao,2 Jin Geng,3 Reizhe Wang,4 Ning Liu,5 Xinghua Gao,6 Noreen Griffin,7 Yuan Gao,8 Fengping Shan1 1Department of Immunology, College of Basic Medical Science, China Medical University, Shenyang, China; 2Department of ...
Wang X +9 more
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Aquaculture Reports, 2020 The involvement of endogenous opioid peptides in regulation of reproductive activity is implicated in a majority of vertebrates. Methionine-enkephalin (M-ENK) is an endogenous opioid peptide neurotransmitter produced in the central nervous system ...
C.B. Ganesh, Vijayalaxmi
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Methionine enkephalin upregulates toll-like receptors in macrophages to suppress severe fever with thrombocytopenia syndrome virus infection [PDF]
Frontiers in ImmunologyBackgroundSevere fever with thrombocytopenia syndrome virus (SFTSV) is a newly identified tick-borne virus with a high case fatality rate. Currently, no specific antiviral drugs are available for its treatment.
Jing Tian +7 more
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Highly sensitive in vivo detection of dynamic changes in enkephalins following acute stress in mice [PDF]
eLifeEnkephalins are opioid peptides that modulate analgesia, reward, and stress. In vivo detection of enkephalins remains difficult due to transient and low endogenous concentrations and inherent sequence similarity.
Marwa O Mikati +8 more
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Methionine enkephalin upregulates the immune function of RAW264.7 cells to inhibit the infection of Nelson Bay orthoreoviruses [PDF]
Scientific ReportsPreliminary research has found that MENK can upregulate the antiviral state of macrophages to inhibit influenza virus infection. To further study the immunomodulatory mechanism of MENK in macrophages against reovirus, we used RNA-Seq technology to ...
Xiaoli Tao +4 more
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Iraqi Journal of Pharmaceutical Sciences, 2017 A small number of researches were done in the design and synthesis of enkephalin analogues that are able to resist degradation effect of proteolytic enzymes with good bioavailability and half-lives.Through studying structure activity relationships we ...
Muthanna S. Al-Ttaee +2 more
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Extracellular processing of proopiomelanocortin generates short beta endorphin that regulates rat keratinocytes via the delta opioid receptor [PDF]
Scientific ReportsProopiomelanocortin (POMC), a precursor with multiple bioactive peptides, is expressed by keratinocytes and regulates various pathophysiological responses, including pruritus associated with atopic dermatitis (AD).
Hiroyuki Yamamoto +3 more
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Adrenergic Agonists Bind to Adrenergic-Receptor-Like Regions of the Mu Opioid Receptor, Enhancing Morphine and Methionine-Enkephalin Binding: A New Approach to "Biased Opioids"? [PDF]
Int J Mol Sci, 2018 Root-Bernstein R +4 more
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