The novel mechanism of anticancer effect on gastric cancer through inducing G0/G1 cell cycle arrest and caspase-dependent apoptosis in vitro and in vivo by methionine enkephalin [PDF]
Cancer Management and Research, 2018 Xiaonan Wang,1 Jing Tian,1 Xue Jiao,2 Jin Geng,3 Reizhe Wang,4 Ning Liu,5 Xinghua Gao,6 Noreen Griffin,7 Yuan Gao,8 Fengping Shan1 1Department of Immunology, College of Basic Medical Science, China Medical University, Shenyang, China; 2Department of ...
Wang X +9 more
doaj +3 more sources
Methionine Enkephalin Suppresses Osteocyte Apoptosis Induced by Compressive Force through Regulation of Nuclear Translocation of NFATc1 [PDF]
JBMR Plus, 2020 Mechanical stress stimulates bone remodeling, which occurs through bone formation and resorption, resulting in bone adaptation in response to the mechanical stress. Osteocytes perceive mechanical stress loaded to bones and promote bone remodeling through
Chisumi Sogi +14 more
doaj +4 more sources
Methionine enkephalin (MENK) improves lymphocyte subpopulations in human peripheral blood of 50 cancer patients by inhibiting regulatory T cells (Tregs). [PDF]
Hum Vaccin Immunother, 2014 MENK, a penta-peptide is considered as being involved in the regulatory feedback loop between the immune and neuroendocrine systems, with marked modulation of various functions of human immune cells.
Wang Q +8 more
europepmc +4 more sources
Methionine enkephalin (MENK) protected macrophages from ferroptosis by downregulating HMOX1 and ferritin [PDF]
Proteome ScienceObjective The aim of this work was to investigate the immunological effect of MENK by analyzing the protein spectrum and bioinformatics of macrophage RAW264.7, and to explore the relationship between macrophage and ferroptosis.
Jing Tian +5 more
doaj +4 more sources
Methionine enkephalin(MENK) upregulated memory T cells in anti-influenza response [PDF]
BMC Immunology, 2023 Novel prophylactic drugs and vaccination strategies for protection against influenza virus should induce specific effector T-cell immune responses in pulmonary airways and peripheral lymphoid organs.
Jing Tian +6 more
doaj +2 more sources
Proteomics analysis of methionine enkephalin upregulated macrophages against infection by the influenza-A virus [PDF]
Proteome Science, 2023 Macrophages have a vital role in phagocytosis and antiviral effect against invading influenza viruses. Previously, we found that methionine enkephalin (MENK) inhibited influenza virus infection by upregulating the “antiviral state” of macrophages.
Wenrui Fu +5 more
doaj +2 more sources
Killing effect of methionine enkephalin on melanoma in vivo and in vitro. [PDF]
Oncol Rep, 2017 Melanoma is a common cutaneous malignancy, that is also found in specific mucosal sites, and is associated with a poor prognosis. The aim of the present study was to investigate the cytotoxicity of methionine enkephalin (MENK) for B16 melanoma cells in ...
Wang DM +6 more
europepmc +2 more sources
The distribution of methionine‐enkephalin and leucine‐enkephalin in the brain and peripheral tissues [PDF]
British Journal of Pharmacology, 1997 A method is described for the rapid extraction of opioid peptides from the brain and other tissues. The method is based on acid extraction of tissues followed by adsorption of the extract onto Amberlite XAD‐2 resin. Elution with methanol separates the enkephalins and α‐endorphin from β‐endorphin.
Joel W. Hughes +2 more
+9 more sources
Inhibition of the growth of human melanoma cells by methionine enkephalin. [PDF]
Mol Med Rep, 2016 Melanoma is an aggressive cancer, the incidence of which is increasing worldwide. Limited therapies are currently available, particularly following metastasis. The aim of the present study was to investigate the inhibiting effect of methionine enkephalin
Wang DM +8 more
europepmc +2 more sources
Methionine enkephalin (MENK) inhibits tumor growth through regulating CD4+Foxp3+ regulatory T cells (Tregs) in mice. [PDF]
Cancer Biol Ther, 2015 Methionine enkephalin (MENK), an endogenous neuropeptide, plays an crucial role in both neuroendocrine and immune systems. CD4+Foxp3+ regulatory T cells (Tregs) are identified as a major subpopulation of T lymphocytes in suppressing immune system to keep
Li X +7 more
europepmc +2 more sources