Results 111 to 120 of about 14,571 (197)

Mfn2 induces NCLX-mediated calcium release from mitochondria.

bioRxiv : the preprint server for biology
Mfn2 is a mitochondrial outer membrane fusion protein with the additional role of tethering mitochondria to the ER. Here, we describe a novel connection between Mfn2 and calcium release from mitochondria. We show that Mfn2 controls the mitochondrial inner membrane sodium-calcium exchange protein NCLX, which is a major source for calcium release from ...
Kolitsida, Panagiota, Saha, Akash, Caliri, Andrew, Assali, Essam, Riera, Alejandro Martorell, Itskanov, Samuel, Magana, Catalina S., Stork, Björn, Shirihai, Orian, Sekler, Israel, Koehler, Carla M., van der Bliek, Alexander M.   +11 more
openaire   +2 more sources

MFN2 Gene [PDF]

, 2020
openaire   +1 more source

Role of Mfn2 in Macrophage Inflammatory Responses

, 2017
[eng] Mitochondria are well known for their role as bioenergetic and biosynthetic organelles. Recently, they also have emerged as one of the main regulators of innate immune responses, mostly for its ability to modulate several signaling pathways through mechanisms such ROS production.
openaire   +1 more source

MFN2 wt Allele [PDF]

, 2020
openaire   +1 more source

Lidamycin induces mitophagy in pancreatic cancer cells by regulating the expression of Mfn2

Scientific Reports
Lidamycin (LDM) has been confirmed to have a strong anti-pancreatic cancer effect and can affect the mitochondrial function of pancreatic cancer cells. Mitofusin-2 (Mfn2) is located in the outer membrane of mitochondria, and Mfn2 is currently believed to
Boya Wu, Bing Qi, Liumeng Duan, Jing Chen   +3 more
doaj   +1 more source

Mitofusin 2 Attenuates Adenomyosis Progression by Suppressing Epithelial-Mesenchymal Transition: Evidence From Clinical and Experimental Models

Clinical and Experimental Obstetrics & Gynecology
Background: Adenomyosis involves epithelial-mesenchymal transition (EMT), yet the role of mitochondrial regulator Mitofusin 2 (Mfn2) remains unclear. This study investigated the role of Mfn2 in adenomyosis-related EMT and evaluated its
Xuan Wang, Qing Han, Xin Qin, Nana Xu, Chun Ding, Hong Ye   +5 more
doaj   +1 more source

Cognitive decline in Mfn2 KO mice: role of Mfn2 in neuronal plasticity

[cat] La Mitofusina 2 (Mfn2) és una proteïna inicialment caracteritzada com una proteïna de fusió mitocondrial amb una funció bioenergètica, com la Mitofusina 1. Més enllà del seu paper en la bioenergètica, la Mfn2 també actua com una proteïna d’unió entre el reticle endoplasmàtic (RE) i els mitocondris, el qual juga un paper crític en la regulació de ...
openaire   +1 more source

Correction: Impaired mitochondrial dynamics and removal of the damaged mitochondria in diabetic retinopathy. [PDF]

Front Endocrinol (Lausanne)
Alka K, Kumar J, Kowluru RA.
europepmc   +1 more source

miR-103a-3p contributes to diabetic retinopathy progression via suppressing MFN2. [PDF]

Diabetol Metab Syndr
Liu Y, Zhao Y, Liu J, Wu M, Zhang Q.
europepmc   +1 more source

Mitofusins are required for specialized mitochondrial morphology and function of rod photoreceptor cells. [PDF]

Front Cell Dev Biol
Landowski M, Hagimori R, Gogoi P, Shahi PK, Oikawa K, Bhute VJ, McLellan GJ, Ikeda S, Yamada KI, Pattnaik BR, Takimoto T, Ikeda A.   +11 more
europepmc   +1 more source