Results 111 to 120 of about 3,353 (142)

Hypoxia‐induced vulnerability of the somatosensory nervous system

The Journal of Physiology, EarlyView.
Abstract figure legend Sensory neurons are highly energy dependent and rely on sufficient oxygen availability to maintain metabolic stability and effective neurocommunication. Within the somatosensory system, even modest reductions in tissue oxygen tension impair neuronal respiration, forcing a shift toward less efficient metabolic pathways that ...
Jack Corbett, Richard P. Hulse
wiley   +1 more source

IPS-1 interacts with MFN1 and MFN2.

, 2013
IPS-1-HeLa cells were infected with NDV for 12 h, and then FLAG-IPS-1 was immunoprecipitated with anti-FLAG antibody. Co-immunoprecipitated MFN1 and MFN2 were detected by anti-MFN1 antibody and anti-MFN2 antibody, respectively.
Shiori Takamatsu (107244), Hideo Namiki (143798), Michihiko Jogi (143790), Shiho Morimoto (143791), Ilkka Julkunen (175083), Koji Onomoto (107253), Kazuhide Onoguchi (107248), Azumi Takemura (143792), Mitsutoshi Yoneyama (107267), Takashi Fujita (89133)   +9 more
core   +1 more source

Musculoskeletal (Mal)adaptations in Response to a > 30 000‐km Running Challenge

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 5, October 2026.
ABSTRACT Background Ultra‐endurance sports are increasingly popular, yet the long‐term physiological consequences of sustained extreme training loads remain poorly understood. In particular, the effects of prolonged ultra‐endurance exercise on skeletal muscle structure, function and molecular remodelling are largely unknown.
Tomas Venckunas, Thomas Chaillou, Leonardo Cesanelli, Danguole Satkunskiene, Saulius Rutkauskas, Audrius Snieckus, Petras Minderis, Darja Nikitina, Jurgita Skieceviciene, Juozas Kupcinskas, Lorenz Webersberger, Johanna T. Lanner, Mantas Mickevicius, Birutė Gumauskiene, Asta Kuzmickaite, Andrejus Subocius, Sigitas Kamandulis   +16 more
wiley   +1 more source

Aging of Skeletal Muscle: From Molecular Mechanisms to Therapeutic Interventions

MedComm, Volume 7, Issue 10, October 2026.
Skeletal muscle aging is driven by coordinated local breakdown across myofibers, stem and stromal cells, immune and vascular compartments, and neuromuscular control. These mechanisms promote mitochondrial dysfunction, inflammation, senescence, impaired regeneration, fibrosis, myosteatosis, denervation, and functional decline.
Ting Liu, Yaomin Hu
wiley   +1 more source

Mfn2 is critical for brown adipose tissue thermogenic function

Mitochondrial fusion and fission events, collectively known as mitochondrial dynamics, act as quality control mechanisms to ensure mitochondrial function and fine-tune cellular bioenergetics.
Boutant, Marie, Kulkarni, Sameer S., Joffraud, Magali, Zorzano, Antonio, Ratajczak, Joanna, Combe, Roy, Valera-Alberni, Miriam, Canto, Carles   +7 more
core   +1 more source

Loss of Mfn1 but not Mfn2 enhances adipogenesis. [PDF]

OBJECTIVE: A biallelic missense mutation in mitofusin 2 (MFN2) causes multiple symmetric lipomatosis and partial lipodystrophy, implicating disruption of mitochondrial fusion or interaction with other organelles in adipocyte differentiation, growth and ...

core   +12 more sources

Mitofusin 2 Attenuates Adenomyosis Progression by Suppressing Epithelial-Mesenchymal Transition: Evidence From Clinical and Experimental Models

Clinical and Experimental Obstetrics & Gynecology
Background: Adenomyosis involves epithelial-mesenchymal transition (EMT), yet the role of mitochondrial regulator Mitofusin 2 (Mfn2) remains unclear. This study investigated the role of Mfn2 in adenomyosis-related EMT and evaluated its
Xuan Wang, Qing Han, Xin Qin, Nana Xu, Chun Ding, Hong Ye   +5 more
doaj   +1 more source

Mitochondrial Fusion and Fission in Age‐Related Cardio‐Cerebral Diseases: Mechanisms and Interventions

Aging Cell, Volume 25, Issue 10, October 2026.
Mitochondrial fission‐fusion imbalance contributes to age‐related cardio‐cerebral diseases like Alzheimer's disease, Parkinson's disease, Cerebral Infarction, Arteriosclerosis, Myocardial Infarction, Cardiac valve disease, Hypertension, and Cardiomyopathy. This review summarizes its regulatory mechanisms and interventions.
Yuyao Yin, Zijian Li
wiley   +1 more source

피부 편평세포암의 예후 예측 인자로써 MFN2 유전자 발현의 역할

, 2020
Although vast amount of research has been done on genes related to cancers, it remains unclear whether Mitofusin2 (MFN2) functions as a tumor suppressor or oncoprotein in cancer progression.
조미연
core  

Mitofusin2 ameliorates ischemia-induced injury and serves as a biomarker for a diagnostic nomogram in ischemic cardiomyopathy

European Journal of Medical Research
Objectives To integrate clinical findings with mechanistic exploration to elucidate the role, potential mechanisms, and clinical translational value of Mitofusin2 (Mfn2) in ischemic cardiomyopathy (ICM).
Salamaiti Aimaier, Tuersunjiang Naman, Aihaidan Abudouwayiti, Refukaiti Abuduhalike, Juan Sun, Ailiman Mahemuti   +5 more
doaj   +1 more source