Results 121 to 130 of about 3,353 (142)

Repeated Moderate and Severe Heat Exposure Has Divergent Effects on Skeletal Muscle Mitochondrial, Proteostatic and Neuromuscular Outcomes in Mice

Acta Physiologica, Volume 242, Issue 10, October 2026.
ABSTRACT Aim Repeated heat exposure may promote adaptive remodeling or cumulative tissue burden depending on thermal dose, but its graded molecular and functional consequences during recovery remain unclear. We examined whether repeated moderate (39°C) and severe (41°C) whole‐body hyperthermia produce distinct skeletal muscle trajectories involving ...
Cansu Yakin, Cihan Suleyman Erdogan, Fatma Ozge Tuncel, Yunus Kosif, Bayram Yilmaz   +4 more
wiley   +1 more source

Doxorubicin and 4‐Hydroperoxycyclophosphamide Alter Mitochondrial Dynamics and miR‐34 Expression in Spermatogonia and Spermatocytes In Vitro

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 4, October 2026.
ABSTRACT Doxorubicin (DOX) and cyclophosphamide (CP) are widely used chemotherapeutic agents with known gonadotoxic effects. Since miRNAs play a key role in the transcriptional regulation of spermatogenesis, they are suggested as biomarkers for male infertility.
Hülya Öztatlıcı, Mahmut Kemal Özbilgin, Rukiye Betül Çolaksel, Suna Karadeniz Saygılı, Mustafa Öztatlıcı   +4 more
wiley   +1 more source

A cellular assay to determine the fusion capacity of MFN2 variants linked to Charcot–Marie-Tooth disease of type 2 A

Charcot–Marie-Tooth Disease (CMT) is an inherited peripheral neuropathy with two main forms: demyelinating CMT1 and axonal CMT2. The most frequent subtype of CMT2 (CMT2A) is linked to mutations of MFN2, encoding a ubiquitously expressed GTP-binding ...
Perrin, Julian, Rojo, Manuel, Manuel Rojo, Mourier, Arnaud, Claudine David, Chloe Barsa, Arnaud Mourier, David, Claudine, Barsa, Chloe, Julian Perrin   +9 more
core   +1 more source

Lidamycin induces mitophagy in pancreatic cancer cells by regulating the expression of Mfn2

Scientific Reports
Lidamycin (LDM) has been confirmed to have a strong anti-pancreatic cancer effect and can affect the mitochondrial function of pancreatic cancer cells. Mitofusin-2 (Mfn2) is located in the outer membrane of mitochondria, and Mfn2 is currently believed to
Boya Wu, Bing Qi, Liumeng Duan, Jing Chen   +3 more
doaj   +1 more source

Mfn2 induces NCLX-mediated calcium release from mitochondria

Mfn2 is a mitochondrial outer membrane fusion protein with the additional role of tethering mitochondria to the ER. Here, we describe a novel connection between Mfn2 and calcium release from mitochondria.
Itskanov, Samuel, Stork, Björn, Shirihai, Orian, Caliri, Andrew, Assali, Essam, Sekler, Israel, Magana, Catalina S., Riera, Alejandro Martorell, Koehler, Carla M, Magana, Catalina S, van der Bliek, Alexander M, Koehler, Carla M., Saha, Akash, van der Bliek, Alexander M., Kolitsida, Panagiota   +14 more
core   +1 more source

The promoter activity of human Mfn2 depends on Sp1 in vascular smooth muscle cells

AIMS: Mitofusin-2 (Mfn2) expression is dysregulated in vascular proliferative disorders and its overexpression attenuates the proliferation of vascular smooth muscle cells (VSMCs) and neointimal lesion development after balloon angioplasty.
Sancho Medina, Ana, Zaragoza, Francesc X. (Francesc Xavier), Portugal, José, 1954-, Zorzano Olarte, Antonio, Fernández Pascual, Sergio, Palacín Prieto, Manuel, Sorianello, Eleonora, Naón Elbirt, Déborah P., Vila Caballer, Marian, González Navarro, Herminia, Andrés García, Vicente   +10 more
core   +1 more source

Anti-Tumor Effects of Mfn2 in Gastric Cancer

International Journal of Molecular Sciences, 2013
Mitofusin-2 (Mfn2) is a mitochondrial outer membrane protein involved in mitochondrial fusion. Its mutation can cause Charcot-Marie-Tooth disease. Recent studies of Mfn2 in cancer research have not included gastric cancer.
Ji-Ren Yu, Xiao-Sun Liu
exaly   +2 more sources

Some of the next articles are maybe not open access.

Related searches:

Mfn2 localization in the ER is necessary for its bioenergetic function and neuritic development

EMBO Reports, 2021
Aleix Gavaldà Navarro, Raquel Larramona Arcas, Manuel Reina   +2 more
exaly  

The AMPK-MFN2 axis regulates MAM dynamics and autophagy induced by energy stresses

Autophagy, 2021
Dongxing Zhu, Longxuan Li, Du Feng
exaly  

Mitochondrial Fusion Protein Mfn2 and Its Role in Heart Failure

Frontiers in Molecular Biosciences, 2021
Guohua Gong, Bilin Liu
exaly