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Mfn2 is involved in intervertebral disc degeneration through autophagy modulation [PDF]
Osteoarthritis and Cartilage, 2020 To explore whether Mitofusin 2 (Mfn2) is implicated in the pathogenesis of intervertebral disc degeneration (IVDD).We detected the protein content of Mfn2 in degenerated human nucleus pulposus (NP) tissues and investigated the effects of Mfn2 knockdown and Mfn2 overexpression on rat nucleus pulposus cells (NPCs) under oxidative stress by using a range ...
Y, Chen +7 more
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Regulation of MFN2 by berberine alleviates obesity exacerbated colitis
Biochemical and Biophysical Research Communications, 2020Obesity has become a global health issue, which can cause metabolic abnormalities systemically leading to increased morbidity of series diseases. At present, researches have presented obesity is a high-risk factor for colitis, and berberine shows positive therapeutic effect on colitis.
Youlan Chen +3 more
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Acute optic neuropathy associated with a novel MFN2 mutation
Journal of Neurology, 2015Mutations in the mitofusin 2 (MFN2) gene cause CMT2A the most common form of autosomal dominant axonal Charcot-Marie-Tooth (CMT). In addition, mutations in MFN2 have been shown to be responsible for Hereditary Motor Sensory Neuropathy type VI (HSMN VI), a rare early-onset axonal CMT associated with optic neuropathy.
LEONARDI, LUCA +8 more
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MFN2 might be a risk factor for lung adenocarcinoma.
Journal of Clinical Oncology, 2017e13007 Background: Genetic mutations in Mitofusin-2(MFN2) interrupt mitochondrial fusion and cause the untreatable neurodegenerative condition Charcot-Marie-Tooth disease type 2A( Nature, December 2016). MFN2 was initially identified as a hypertension-associated gene and implicated in the pathogenesis of multiple cancer types.
Yuqing Lou +8 more
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Martin Burtscher, Johannes Burtscher
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MFN2-related neuropathies: Clinical features, molecular pathogenesis and therapeutic perspectives
Journal of the Neurological Sciences, 2015Mitofusin 2 (MFN2) is a GTPase dynamin-like protein of the outer mitochondrial membrane, encoded in the nuclear genome by the MFN2 gene located on the short (p) arm of chromosome 1. MFN2 protein is involved in several intracellular pathways, but is mainly involved in a network that has an essential role in several mitochondrial functions, including ...
G. Stuppia +8 more
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TCDD Induces Hepatocytes Lipid Deposition via Downregulation of MFN2
Journal of Applied ToxicologyABSTRACT The persistent environmental pollutant 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD) has been implicated in hepatic lipid metabolism disorders and steatosis. However, the precise mechanisms underlying TCDD‐induced hepatic lipid deposition remain incompletely elucidated.
Changming, Xing +7 more
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[Mitochondrial fusion protein Mfn2 and cardiovascular diseases].
Sheng li ke xue jin zhan [Progress in physiology], 2012Mitofusin 2 (Mfn2) is a mitochondrial dynamin-related protein involved in the mitochondrial fusion reaction and is also connected to an altered mitochondrial energy supply. Mfn2 is a signaling molecule, plays an important role in cell proliferation, differentiation and apoptosis, which participates in the pathophysiology of several cardiovascular ...
Hai-Yi, Yu, Yan-Hong, Guo, Wei, Gao
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Mfn2 localization in the ER is necessary for its bioenergetic function and neuritic development
EMBO Reports, 2021Sergi Casellas-Díaz +2 more
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