Results 151 to 160 of about 21,491 (246)

Mechanical Force Promotes Mitochondrial Transfer From Macrophages to BMSCs to Enhance Bone Formation

Cell Proliferation, Volume 59, Issue 5, May 2026.
Mechanical tension activates Drp1‐mediated mitochondrial fission in macrophages, facilitating the release of Mito‐EVs that are subsequently transferred to BMSCs. Additionally, the CD200R‐CD200 interaction enhances the uptake of these mechanically stimulated macrophage‐derived Mito‐EVs by BMSCs, ultimately promoting osteogenic differentiation.
Yingyi Li, Ziwei Yan, Yueming Dai, Hanjia Cai, Yue Chen, Yuyi Chen, Ruofan Jin, Wen Sun, Hua Wang   +8 more
wiley   +1 more source

Growth differentiation factor 15 mitigates lipotoxic steatosis by preserving mitochondrial morphodynamics and augmenting fatty acid oxidation in hepatocytes and liver organoids

Diabetes, Obesity and Metabolism, Volume 28, Issue 5, Page 3788-3806, May 2026.
Abstract Aims Growth differentiation factor 15 (GDF15) has emerged as a promising metabolic regulator with hepatoprotective properties in metabolic dysfunction‐associated steatotic liver disease (MASLD), yet its underlying mechanisms remain elusive.
Jia Li, Qi Zhou, Mengmeng Xia, Yakun Li, Junyu Wang, Manon Buist‐Homan, Vincent E. de Meijer, Hans Blokzijl, Klaas Nico Faber, Han Moshage   +9 more
wiley   +1 more source

The MFN2 Q367H variant reveals a novel pathomechanism connected to mtDNA-mediated inflammation

Life Science Alliance
The present study describes a novel pathogenic variant in MFN2 from a patient with late-onset distal myopathy and links pathogenic perturbation of MFN2 function to mitochondrial DNA release and inflammation.
Mashiat Zaman, Govinda Sharma, Walaa Almutawa, Tyler GB Soule, Rasha Sabouny, Matt Joel, Armaan Mohan, Cole Chute, Jeffrey T Joseph, Gerald Pfeffer, Timothy E Shutt   +10 more
doaj   +1 more source

Skeletal muscle mitochondrial marker responses to a single bout and 6 weeks of high load versus high volume resistance training in previously trained men

Experimental Physiology, Volume 111, Issue 5, Page 2564-2574, 1 May 2026.
Abstract The effects of high‐load (HL) versus high‐volume (HV) resistance training (RT) on various molecular outcomes are similar. However, mitochondrial responses remain understudied. Therefore, the purpose of this study was to interrogate mitochondrial mRNA and protein responses to acute and chronic HL versus HV RT.
Breanna Mueller, Carlton D. Fox, Hailey A. Parry, Paulo H. C. Mesquita, Christopher G. Vann, Bradley A. Ruple, Casey L. Sexton, Joshua S. Godwin, Mason M. McIntosh, Darren T. Beck, Kaelin C. Young, Stuart M. Phillips, Andreas N. Kavazis, Michael D. Roberts   +13 more
wiley   +1 more source

Expression of mitofusin 2R94Q in a transgenic mouse leads to Charcot-Marie-Tooth neuropathy type 2A [PDF]

, 2017
Charcot-Marie-Tooth disease type 2A is an autosomal dominant axonal form of peripheral neuropathy caused by mutations in the mitofusin 2 gene. Mitofusin 2 encodes a mitochondrial outer membrane protein that participates in mitochondrial fusion in ...
Arnaud, Estelle, Cartoni, Romain, Chrast, Roman, Courvoisier, Delphine S., Martinou, Jean-Claude, Médard, Jean-Jacques, Poirot, Olivier   +6 more
core  

ChREBP‐β Exacerbates Renal Tubular Disorders Caused by Fructose via ATF4

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
Schematic diagram of the mechanism underlying fructose‐induced renal tubular injury via ChREBP‐β‐mediated disruption of endoplasmic reticulum and mitochondrial homeostasis. This diagram illustrates that fructose induces the transcriptional activation of ChREBP‐β, which subsequently triggers endoplasmic reticulum stress, disturbs inter‐organelle calcium
Ting Fang, Xinyu Yang, Xiaoqing Deng, Jingyi Wang, Ting Li, Hang Guo, Bei Sun, Liming Chen   +7 more
wiley   +1 more source

MFN2 Gene [PDF]

, 2020
openaire   +1 more source

MFN2 wt Allele [PDF]

, 2020
openaire   +1 more source

Mitofusin 2 Attenuates Adenomyosis Progression by Suppressing Epithelial-Mesenchymal Transition: Evidence From Clinical and Experimental Models

Clinical and Experimental Obstetrics & Gynecology
Background: Adenomyosis involves epithelial-mesenchymal transition (EMT), yet the role of mitochondrial regulator Mitofusin 2 (Mfn2) remains unclear. This study investigated the role of Mfn2 in adenomyosis-related EMT and evaluated its
Xuan Wang, Qing Han, Xin Qin, Nana Xu, Chun Ding, Hong Ye   +5 more
doaj   +1 more source

Mfn2 IS REQUIRED IN REGULATING SPERMATOGONIAL DIFFERENTIATION AND MEIOSIS [PDF]

Fertility and Sterility, 2021
Xueli Chen, Chenxi Guo, Zhe Hu, Yuan Xiao, Jingkai Gu, William S.B. Yeung, Tianren Wang   +6 more
openaire   +1 more source