Results 161 to 170 of about 21,491 (246)

Lidamycin induces mitophagy in pancreatic cancer cells by regulating the expression of Mfn2

Scientific Reports
Lidamycin (LDM) has been confirmed to have a strong anti-pancreatic cancer effect and can affect the mitochondrial function of pancreatic cancer cells. Mitofusin-2 (Mfn2) is located in the outer membrane of mitochondria, and Mfn2 is currently believed to
Boya Wu, Bing Qi, Liumeng Duan, Jing Chen   +3 more
doaj   +1 more source

Role of Mfn2 in Macrophage Inflammatory Responses

, 2017
[eng] Mitochondria are well known for their role as bioenergetic and biosynthetic organelles. Recently, they also have emerged as one of the main regulators of innate immune responses, mostly for its ability to modulate several signaling pathways through mechanisms such ROS production.
openaire   +2 more sources

miR-373-3p promotes aerobic glycolysis in colon cancer cells by targeting MFN2: MiR-373-3p promotes glycolysis through MFN2

MicroRNAs (miRNAs) are implicated in the development of cancers and may serve as potential targets for therapy. However, the functions and underlying mechanisms of miRNAs in cancers are not well understood. This work aims to study the role of miR-373-3p in colon cancer cells.
Wang, Yu, Lun, Jie, Zhang, Yuying, Yu, Mengchao, Liu, Xingqian, Guo, Jing, Zhang, Hongwei, Qiu, Wensheng, Fang, Jing   +8 more
openaire   +1 more source

Long-term live-cell microscopy with labeled nanobodies delivered by laser-induced photoporation

, 2020
Boukherroub, Rabah, Braeckmans, Kevin, Brans, Toon, De Keersmaecker, Herlinde, De Smedt, Stefaan, De Vos, Winnok H., Gettemans, Jan, Hebbrecht, Tim, Li, Chengnan, Lippens, Saskia, Liu, Jing, Parthoens, Eef, Xiong, Ranhua   +12 more
core   +1 more source

Mitofusin-2 suppresses tumor immune escape through EGFR/STAT3-mediated PD-L1 transcription. [PDF]

Cell Death Dis
Liu Y, Wang N, Li Z, Li N, Hui F, Wang X, Tang G, Zhang Q, Yu G, Liu S, Ding Y.   +10 more
europepmc   +1 more source

Arginine ameliorates motor and survival deficits in MFN2-Deficient Drosophila models. [PDF]

Neurotherapeutics
Ando M, Okamoto Y, Higuchi Y, Yuan JH, Yoshimura A, Yano C, Nagatomo R, Hobara T, Kojima F, Hiramatsu Y, Nozuma S, Sakiyama Y, Takashima H.   +12 more
europepmc   +1 more source

STIM1-Mitofusin2 interactions tether mitochondria and melanosome contacts that promote melanosome maturation. [PDF]

Nat Commun
Shiiba I, Ishikawa Y, Oshio H, Ito N, Yamaguchi F, Nagashima S, Ando H, Umezawa K, Miura Y, Araiso Y, Nakamura K, Hirabayashi Y, Inatome R, Yanagi S.   +13 more
europepmc   +1 more source

Mitofusin MFN2 acts as a molecular sensor preventing protein aggregation and mitophagy, with a protective effect against apoptosis in Charcot-Marie-Tooth type 2A disease. [PDF]

Autophagy Rep
Joaquim M, Dohrn MF, Chevrollier A, Escobar-Henriques M.   +3 more
europepmc   +1 more source

E3 Ubiquitin Ligase Nedd4-2 Exacerbates Seizure-Induced Mitochondrial Defects in an Alzheimer's Disease Mouse Model. [PDF]

J Neurochem
Wang Y, Zhu J, Lizarazo S, Lee KY, Wong O, Azim S, Yook Y, Kumar V, Tsai NP.   +8 more
europepmc   +1 more source

AAVrh74.tMCK.NT-3 Surrogate Gene Therapy in a Mouse Model of CMT2A. [PDF]

Int J Mol Sci
Ozes B, Tong L, Moss K, Myers M, Ndengabaganizi I, Sahenk Z.   +5 more
europepmc   +1 more source