Results 211 to 220 of about 21,491 (246)

Mitochondrial miRNA- miR-181c-5p and mitomiR-106a-5p levels as indicators in cardiovascular disease patients. [PDF]

Mol Biol Rep
Nabi A, Yashooa RK, Faraj TA, Mohammad KA, Mustafa SA, Troiano G, Dioguari M, Al-Farha AA, Capitanio N.   +8 more
europepmc   +1 more source

Thyroid Hormone Receptor β1 and PGC1α Coordinately Regulate OPA1/MFN2-Mediated Mitochondrial Fusion and UCP1-Mediated Lipid Browning in ccRCC. [PDF]

Adv Sci (Weinh)
Meng X, Yu T, Lv F, Li W, Yang H, Zhang X, Xiao W.   +6 more
europepmc   +1 more source

Correction to: Inhibition of USP30 Promotes Mitophagy by Regulating Ubiquitination of MFN2 by Parkin to Attenuate Early Brain Injury after SAH. [PDF]

Transl Stroke Res
Liu Y, Yao C, Sheng B, Zhi S, Chen X, Ding P, Zhang J, Tao Z, Li W, Zhuang Z, Mao J, Peng Z, Yan H, Jin W.   +13 more
europepmc   +1 more source

Anti-Tumor Effects of Mfn2 in Gastric Cancer [PDF]

International Journal of Molecular Sciences, 2013
Mitofusin-2 (Mfn2) is a mitochondrial outer membrane protein involved in mitochondrial fusion. Its mutation can cause Charcot-Marie-Tooth disease. Recent studies of Mfn2 in cancer research have not included gastric cancer. We confirmed that Mfn2 expression was lower in tumor tissue than in normal gastric mucosal tissue and that it was negatively ...
Zhang, Ge-Er, Jin, Hai-Long, Lin, Xian-Ke, Chen, Chao, Liu, Xiao-Sun, Zhang, Qing, Yu, Ji-Ren   +6 more
exaly   +3 more sources

Mfn2 is involved in intervertebral disc degeneration through autophagy modulation [PDF]

Osteoarthritis and Cartilage, 2020
To explore whether Mitofusin 2 (Mfn2) is implicated in the pathogenesis of intervertebral disc degeneration (IVDD).We detected the protein content of Mfn2 in degenerated human nucleus pulposus (NP) tissues and investigated the effects of Mfn2 knockdown and Mfn2 overexpression on rat nucleus pulposus cells (NPCs) under oxidative stress by using a range ...
Y, Chen, J, Lin, J, Chen, C, Huang, Z, Zhang, J, Wang, K, Wang, X, Wang   +7 more
exaly   +3 more sources

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Acute optic neuropathy associated with a novel MFN2 mutation

Journal of Neurology, 2015
Mutations in the mitofusin 2 (MFN2) gene cause CMT2A the most common form of autosomal dominant axonal Charcot-Marie-Tooth (CMT). In addition, mutations in MFN2 have been shown to be responsible for Hereditary Motor Sensory Neuropathy type VI (HSMN VI), a rare early-onset axonal CMT associated with optic neuropathy.
LEONARDI, LUCA, MARCOTULLI, CHRISTIAN, Storti, Eugenia, Tessa, Alessandra, SERRAO, Mariano, Parisi, Vincenzo, Santorelli, F. M., PIERELLI, Francesco, CASALI, Carlo   +8 more
openaire   +2 more sources

Regulation of MFN2 by berberine alleviates obesity exacerbated colitis

Biochemical and Biophysical Research Communications, 2020
Obesity has become a global health issue, which can cause metabolic abnormalities systemically leading to increased morbidity of series diseases. At present, researches have presented obesity is a high-risk factor for colitis, and berberine shows positive therapeutic effect on colitis.
Youlan Chen, Yiyuan Zheng, Shuting Wen, Fengbin Liu   +3 more
openaire   +2 more sources

Phenotypic spectrum of MFN2 mutations in the Spanish population

Journal of Medical Genetics, 2009
Introduction The most common form of axonal Charcot–Marie–Tooth (CMT) disease is type 2A, caused by mutations in the mitochondrial GTPase mitofusin 2 (MFN2). Objective The objective of our study is to establish the incidence of MFN2 mutations in a ...
Casasnovas, C., Banchs, I., Cassereau, Julien, Gueguen, Naïg, Chevrollier, Arnaud, Martinez-Matos, J., Bonneau, Dominique, Volpini, V.   +7 more
openaire   +3 more sources