Results 221 to 230 of about 21,491 (246)
Some of the next articles are maybe not open access.
MFN2 Prevents Neointimal Hyperplasia in Vein Grafts via Destabilizing PFK1
Circulation Research, 2022Background: Mechanical forces play crucial roles in neointimal hyperplasia after vein grafting; yet, our understanding of their influences on vascular smooth muscle cell (VSMC) activation remains rudimentary. Methods: A cuff mouse model was used to study vein graft hyperplasia ...
Yuanjun Tang +9 more
openaire +2 more sources
Melatonin prevents adverse myocardial infarction remodeling via Notch1/Mfn2 pathway
Free Radical Biology and Medicine, 2016Mitochondrial dysfunction is linked with myocardial infarction (MI), a disorder in which Notch1 has attracted increasing attention. However, the involvement of Notch1 in mitochondrial impairment after an MI is poorly understood, as is the role of mitochondrial fusion-associated protein 2 (Mfn2).
Haifeng Pei, Lei He, Erhe Gao
exaly +3 more sources
MFN2-related neuropathies: Clinical features, molecular pathogenesis and therapeutic perspectives
Journal of the Neurological Sciences, 2015Mitofusin 2 (MFN2) is a GTPase dynamin-like protein of the outer mitochondrial membrane, encoded in the nuclear genome by the MFN2 gene located on the short (p) arm of chromosome 1. MFN2 protein is involved in several intracellular pathways, but is mainly involved in a network that has an essential role in several mitochondrial functions, including ...
G. Stuppia +8 more
openaire +3 more sources
[Mitochondrial fusion protein Mfn2 and cardiovascular diseases].
Sheng li ke xue jin zhan [Progress in physiology], 2012Mitofusin 2 (Mfn2) is a mitochondrial dynamin-related protein involved in the mitochondrial fusion reaction and is also connected to an altered mitochondrial energy supply. Mfn2 is a signaling molecule, plays an important role in cell proliferation, differentiation and apoptosis, which participates in the pathophysiology of several cardiovascular ...
Hai-Yi, Yu, Yan-Hong, Guo, Wei, Gao
openaire +1 more source
MFN2 might be a risk factor for lung adenocarcinoma.
Journal of Clinical Oncology, 2017e13007 Background: Genetic mutations in Mitofusin-2(MFN2) interrupt mitochondrial fusion and cause the untreatable neurodegenerative condition Charcot-Marie-Tooth disease type 2A( Nature, December 2016). MFN2 was initially identified as a hypertension-associated gene and implicated in the pathogenesis of multiple cancer types.
Yuqing Lou +8 more
openaire +1 more source
Martin Burtscher, Johannes Burtscher
openaire +2 more sources
The AMPK-MFN2 axis regulates MAM dynamics and autophagy induced by energy stresses
Autophagy, 2021Yongquan Hu, Hualin Fan, Tian Meng
exaly
TCDD Induces Hepatocytes Lipid Deposition via Downregulation of MFN2
Journal of Applied ToxicologyABSTRACTThe persistent environmental pollutant 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD) has been implicated in hepatic lipid metabolism disorders and steatosis. However, the precise mechanisms underlying TCDD‐induced hepatic lipid deposition remain incompletely elucidated.
Changming Xing +7 more
openaire +1 more source
Cognitive decline in Mfn2 KO mice: role of Mfn2 in neuronal plasticity
[cat] La Mitofusina 2 (Mfn2) és una proteïna inicialment caracteritzada com una proteïna de fusió mitocondrial amb una funció bioenergètica, com la Mitofusina 1. Més enllà del seu paper en la bioenergètica, la Mfn2 també actua com una proteïna d’unió entre el reticle endoplasmàtic (RE) i els mitocondris, el qual juga un paper crític en la regulació de ...openaire +1 more source
Mfn2 localization in the ER is necessary for its bioenergetic function and neuritic development
EMBO Reports, 2021Sergi Casellas-Díaz +2 more
exaly