Results 101 to 110 of about 1,176 (169)

Tri‐domain proteins 27 alleviates ischemia‐reperfusion injury‐induced acute kidney injury by promoting Gli‐like transcription factor 1 expression via the inhibition of polycomb repressive complex 2 activity

Journal of Cell Communication and Signaling, Volume 19, Issue 3, September 2025.
Abstract Dedifferentiated renal tubular epithelial cell (RTEC) proliferation contributes to renal repair following acute kidney injury (AKI) induced by renal ischemia‐reperfusion (I/R) injury (RIRI). However, the fundamental mechanism underlying RTEC dedifferentiation remains unclear.
Chongxiang Xiong, Haishan Chen, Baoting Su, Li Zhang, Jingxiang Hu, Qiaowen Wang, Shougang Zhuang   +6 more
wiley   +1 more source

Liver X Receptor Activation Alleviates Hepatic Ischemia‐Reperfusion Injury in Diabetes by Inhibiting NF‐κB–NLRP3 Activation

Immunity, Inflammation and Disease, Volume 13, Issue 8, August 2025.
ABSTRACT Introduction Hyperglycemia has been reported to be a crucial factor that aggravates liver ischemia‐reperfusion injury (IRI). Macrophage–mediated inflammatory injury is vital to liver IRI. A positive effect of Liver X receptor (LXR) on diabetes has been proven; however, the function and mechanism of LXR in diabetic liver IRI remain unclear ...
Chuanwei Jiang, Wenzhou Ding, Yuanchang Hu, Chao Yang   +3 more
wiley   +1 more source

EFFECTS OF CONTUSION AND EXHAUSTIVE EXERCISE ON MG53, PTRF IN SKELETAL MUSCLE OF RATS [PDF]

, 2019
Objectives To study the effects of contusion and exhaustive exercise on gene expression of MG53, PTRF, Pax7 and β-catenin in skeletal muscle of rats, and reveal the repair mechanism of skeletal muscle injury.
Tongbin Pan (7856492), Leilei Ye (7856498), Jianjian Jiao (7856504), Xinwei Tong (7856495), Mengjin Ji (7856501)   +4 more
core   +1 more source

COTE1 Regulates AMPKα2 Deubiquitination by Targeting WWP1 Activation to Promote Proliferation and Autophagy in Small Cell Lung Cancer

Journal of Biochemical and Molecular Toxicology, Volume 39, Issue 7, July 2025.
COTE1 regulates the protein stability of AMPKα, maintaining the balance of cellular autophagy and promoting tumor proliferation and survival. ABSTRACT COTE1 expression is significantly upregulated in small cell lung cancer (SCLC) tissues compared to normal lung tissues and promotes SCLC cell proliferation and migration.
Yuhui Ma, Bin Song, Hongxia Guo, Ying Chen, Caihong Cao, Yuchen Hao, Yanmin Zheng, Xu Li   +7 more
wiley   +1 more source

MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction disruptor sensitizes insulin signaling in skeletal muscle [PDF]

, 2016
Mitsugumin 53 (MG53) is an E3 ligase that interacts with and ubiquitinates insulin receptor substrate-1 (IRS-1) in skeletal muscle; thus, an MG53-IRS-1 interaction disruptor (MID), which potentially sensitizes insulin signaling with an elevated level of ...
H Lee, W Y Song, Sungchan Cho, J S Park, N Nguyen, Y G Ko, B W Kim, Kwangman Choi, J J Park, S H Kim, J Hong, H J Kim   +11 more
core   +1 more source

Tissue Engineering and Regenerative Medicine: Perspectives and Challenges

MedComm, Volume 6, Issue 5, May 2025.
Tissue engineering and regenerative medicine. This review presents cell therapy, extracellular vesicle therapy, and tissue engineering in regenerative medicine, highlighting their key historical milestones, clinical applications, and current challenges.
Van T. Hoang, Quyen Thi Nguyen, Trang Thi Kieu Phan, Trang H. Pham, Nhung Thi Hong Dinh, Le Phuong Hoang Anh, Lan Thi Mai Dao, Van Dat Bui, Hong‐Nhung Dao, Duc Son Le, Anh Thi Lan Ngo, Quang‐Duong Le, Liem Nguyen Thanh   +12 more
wiley   +1 more source

Roles and Therapeutic Targeting of Exosomes in Sepsis‐Induced Cardiomyopathy

Journal of Cellular and Molecular Medicine, Volume 29, Issue 8, April 2025.
ABSTRACT Sepsis‐induced cardiomyopathy (SICM) is a complex and fatal manifestation of sepsis, characterised by myocardial dysfunction that exacerbates the clinical prognosis in septic patients. While the pathophysiology of SICM remains incompletely understood, emerging evidence highlights the multifaceted functions of exosomes, small membrane‐bound ...
Rui Fan, Han Liu, Qun Liang
wiley   +1 more source

HFD treatment does not alter MG53 expression in striated muscle. [PDF]

, 2015
(A) Western blotting of gastrocnemius and heart muscles. Ponceau red staining shows sample loading equality. Quantifications of western blot densities exhibit no significant difference in MG53 expression between ND (n = 5) and HFD (n = 7)-treated mice in
Yuqi Cui (736228), Ki Ho Park (342977), Bo Zhang (6559), T. M. Ayodele Adesanya (736230), Xuefeng Zhou (28696), Hua Zhu (131619), Hanley Ma (736226), Frank Yi (494218), Zehua Bian (736227), Tao Tan (204136), Jason Liu (193360), Xinyu Zhou (736229), Zhishui Chen (736231)   +12 more
core   +1 more source

MG53 suppresses NF-κB activation to mitigate age-related heart failure

JCI Insight, 2021
Aging is associated with chronic oxidative stress and inflammation that affect tissue repair and regeneration capacity. MG53 is a TRIM family protein that facilitates repair of cell membrane injury in a redox-dependent manner.
Xiaoliang Wang, Xiuchun Li, Hannah Ong, Tao Tan, Ki Ho Park, Zehua Bian, Xunchang Zou, Erin Haggard, Paul M. Janssen, Robert E. Merritt, Timothy M. Pawlik, Bryan A. Whitson, Nahush A. Mokadam, Lei Cao, Hua Zhu, Chuanxi Cai, Jianjie Ma   +16 more
doaj   +1 more source

Enhancing Muscle Membrane Repair by Gene Delivery of MG53 Ameliorates Muscular Dystrophy and Heart Failure in δ-Sarcoglycan-deficient Hamsters [PDF]

, 2012
Muscular dystrophies (MDs) are caused by genetic mutations in over 30 different genes, many of which encode for proteins essential for the integrity of muscle cell structure and membrane.
Xiao, Xiao, Lin, Peihui, Yuan, Zhenhua, Cai, Chuanxi, Li, Juan, Zhu, Hua, Xiao, Bin, Ma, Jianjie, Tang, Ru-hang, Weisleder, Noah, Qiao, Chunping, Li, Jianbin, Mayer, Christina, He, Bo   +13 more
core   +2 more sources