Results 91 to 100 of about 1,176 (169)

Additional file 1 of Rosuvastatin exerts cardioprotective effect in lipopolysaccharide-mediated injury of cardiomyocytes in an MG53-dependent manner [PDF]

, 2022
Additional file 1: One-way ANOVA with the Tukey’s post-hoc test of cytokine levels, western blotting analysis of MG53 knockdown on the expression levels of signaling components supplementar, and raw data of western ...
Yiquan Lai (12129607), Shaoyi Zheng (8449455), Hongwei Guo (300424), Jian Huang (7250), Jiamao Wang (12129610), Jiawei Zhuang (12129601), Gangyi Cheng (12129604), Zhonggui Shan (12129613)   +7 more
core   +1 more source

Deficient Sarcolemma Repair in ALS: A Novel Mechanism with Therapeutic Potential

Cells, 2022
The plasma membrane (sarcolemma) of skeletal muscle myofibers is susceptible to injury caused by physical and chemical stresses during normal daily movement and/or under disease conditions. These acute plasma membrane disruptions are normally compensated
Ang Li, Jianxun Yi, Xuejun Li, Li Dong, Lyle W. Ostrow, Jianjie Ma, Jingsong Zhou   +6 more
doaj   +1 more source

Reduced Sarcolemmal Membrane Repair Exacerbates Striated Muscle Pathology in a Mouse Model of Duchenne Muscular Dystrophy

Cells, 2022
Duchenne muscular dystrophy (DMD) is a common X-linked degenerative muscle disorder that involves mutations in the DMD gene that frequently reduce the expression of the dystrophin protein, compromising the structural integrity of the sarcolemmal membrane
Brian J. Paleo, Kevin E. McElhanon, Hannah R. Bulgart, Kassidy K. Banford, Eric X Beck, Kristina M. Sattler, Briana N. Goines, Shelby L. Ratcliff, Kelly E. Crowe, Noah Weisleder   +9 more
doaj   +1 more source

The TRIM protein Mitsugumin 53 enhances survival and therapeutic efficacy of stem cells in murine traumatic brain injury

Stem Cell Research & Therapy, 2019
Background Traumatic brain injury (TBI) is a common neurotrauma leading to brain dysfunction and death. Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) hold promise in the treatment of TBI.
Fangxia Guan, Tuanjie Huang, Xinxin Wang, Qu Xing, Kristyn Gumpper, Peng Li, Jishi Song, Tao Tan, Greta Luyuan Yang, Xingxing Zang, Jiewen Zhang, Yuming Wang, Yunlei Yang, Yashi Liu, Yanting Zhang, Bo Yang, Jianjie Ma, Shanshan Ma   +17 more
doaj   +1 more source

MG53 promotes corneal wound healing and mitigates fibrotic remodeling in rodents [PDF]

Communications Biology, 2019
AbstractThe cornea plays an important role in transmitting light and providing protection to the eye, but is susceptible to injury and infection. Standard treatments for corneal wounds include topical lubricants, antibiotics, bandage contact lens, and surgery. However, these measures are often ineffective.
Heather L. Chandler, Tao Tan, Chunlin Yang, Anne J. Gemensky-Metzler, Rita F. Wehrman, Qiwei Jiang, Cornelia M. W. Peterson, Bingchuan Geng, Xinyu Zhou, Qiang Wang, Denis Kaili, T. M. Ayodele Adesanya, Frank Yi, Hua Zhu, Jianjie Ma   +14 more
openaire   +2 more sources

AMPK/SIRT1/PGC‐1α Signaling Pathway: Molecular Mechanisms and Targeted Strategies From Energy Homeostasis Regulation to Disease Therapy

CNS Neuroscience &Therapeutics, Volume 31, Issue 11, November 2025.
The AMPK/SIRT1/PGC‐1α signaling axis integrates energy sensing, epigenetic regulation, and mitochondrial biogenesis to maintain cellular homeostasis. Dysregulation of this pathway is related to neurodegenerative, metabolic, and cardiovascular diseases, highlighting its potential as a multifaceted therapeutic target.
Junyang Chen, Boya Liu, Xinlei Yao, Xiaoming Yang, Jiacheng Sun, Jia Yi, Fei Xue, Jitai Zhang, Yuntian Shen, Bingqian Chen, Hualin Sun   +10 more
wiley   +1 more source

Mitochondria‐Associated Endoplasmic Reticulum Membranes in Health and Diseases

MedComm, Volume 6, Issue 10, October 2025.
As pivotal regulators in diverse physiological and pathological processes, mitochondria‐associated endoplasmic reticulum membranes (MAMs) are critically involved in both health and diseases, including cancers, neurodegenerative disorders, metabolic diseases, cardiovascular diseases.
Hangnan Hong, Zhenyang Guo, Junbo Ge, Hua Li   +3 more
wiley   +1 more source

Diabetic Wound Repair: From Mechanism to Therapeutic Opportunities

MedComm, Volume 6, Issue 10, October 2025.
Diabetic wound healing is compromised by chronic metabolic dysfunction that disrupts essential cellular processes. This review examines key predisposing factors, including neuropathy and vascular disease, characterizes dysfunction in critical cell types such as macrophages and fibroblasts, evaluates limitations of current models, compares established ...
Renyuan Wang, Song Gu, Young Hwa Kim, Aejin Lee, Haodong Lin, Dongsheng Jiang   +5 more
wiley   +1 more source

Hydrogel Microspheres as Versatile Platforms for Biomedical Research: Design, Properties, and Applications

MedComm, Volume 6, Issue 10, October 2025.
Schematic diagram illustrating the comprehensive landscape of hydrogel microspheres (HMs). (A) The components of HMs. (B) Preparation technologies employed in fabricating HMs. (C) The diverse applications of HMs across different fields. (D) The therapeutic applications of HMs in the treatment of various systemic diseases, demonstrating their potential ...
Meng Yang, Yuanyuan Shi, Feng Wang, Xin Zhang, Jiayi Shao, Fan Yang, Hao Sun, Chong Zhang, Zheng Zhou, Jianyong Huang, Pengyu Lv, Patrick Shu‐Hang Yung, Jin Cheng, Hong‐Jie Huang, Jian‐Quan Wang   +14 more
wiley   +1 more source

Sodium salicylate ameliorates exercise-induced muscle damage in mice by inhibiting NF-kB signaling

Journal of Orthopaedic Surgery and Research, 2023
Background Eccentric muscle contraction can cause muscle damage, which reduces the efficiency of exercise. Previous evidence suggested that Sodium salicylate (SS) could improve the repair of aged muscle.
Yiming Wang, Yuning Sun, Chunhui Yang, Bing Han, Sining Wang   +4 more
doaj   +1 more source