Results 1 to 10 of about 221,680 (202)

Inter-individual Variability for High Fat Diet Consumption in Inbred C57BL/6 Mice [PDF]

Frontiers in Nutrition, 2019
Since inbred C57BL/6 mice are known to show inter-individual phenotypic variability for some traits, we tested the hypothesis that inbred C57BL/6 mice display a different tendency to consume a high fat (HF) diet.
Pablo N. De Francesco, María P. Cornejo, Franco Barrile, Guadalupe García Romero, Spring Valdivia, María F. Andreoli, Mario Perello   +6 more
doaj   +5 more sources

Shortcoming of the Mouse Model of Postoperative Ileus: Small Intestinal Lengths Have Similar Variations in In- and Outbred Mice and Cannot Be Predicted by Allometric Parameters [PDF]

Biomedicines
Background/Objectives: The mouse model of postoperative ileus separates the gastrointestinal tract into 15 sections, 10 of which are in the small intestine, to measure intestinal transit time.
Maximiliane von Stumberg, Ejder Akinci, Berkan Ertim, Christina Oetzmann von Sochaczewski   +3 more
doaj   +2 more sources

Deletion of the alpha-synuclein locus in a subpopulation of C57BL/6J inbred mice [PDF]

BMC Neuroscience, 2001
Background The presynaptic protein α-synuclein is involved in a range of neurodegenerative diseases. Here we analyze potential compensatory mechanisms in α-synuclein null mutant mice.
Schoepfer Ralf, Specht Christian G
doaj   +4 more sources

Mixed genetic background better recapitulates developmental and psychiatric phenotypes and heterogeneity than inbred C57BL/6J mice [PDF]

Scientific Reports
Preclinical models of neurodevelopmental and psychiatric conditions often rely on inbred mouse strains like C57BL/6J (B6), which exhibit limited genetic and behavioral variability.
Ana Dudas, Ana Novak, Caroline Gora, Emmanuel Pecnard, Nicolas Azzopardi, Séverine Morisset-Lopez, Lucie P. Pellissier   +6 more
doaj   +2 more sources

A diversity outbred F1 mouse model identifies host-intrinsic genetic regulators of response to immune checkpoint inhibitors

OncoImmunology, 2022
Immune checkpoint inhibitors (ICI) have improved outcomes for a variety of malignancies; however, many patients fail to benefit. While tumor-intrinsic mechanisms are likely involved in therapy resistance, it is unclear to what extent host genetic ...
Justin B. Hackett, James E. Glassbrook, Maria C. Muñiz, Madeline Bross, Abigail Fielder, Gregory Dyson, Nasrin Movahhedin, Jennifer McCasland, Claire McCarthy-Leo, Heather M. Gibson   +9 more
doaj   +1 more source

Chronobiology of alcohol: Studies in C57BL/6J and DBA/2J inbred mice [PDF]

Physiology & Behavior, 2013
Human alcoholics display dramatic disruptions of circadian rhythms that may contribute to the maintenance of excessive drinking, thus creating a vicious cycle. While clinical studies cannot establish direct causal mechanisms, recent animal experiments have revealed bidirectional interactions between circadian rhythms and ethanol intake, suggesting that
Alan M, Rosenwasser, Michael C, Fixaris
openaire   +2 more sources

Neuroimaging Evidence of Major Morpho-Anatomical and Functional Abnormalities in the BTBR T+TF/J Mouse Model of Autism [PDF]

, 2013
BTBR T+tf/J (BTBR) mice display prominent behavioural deficits analogous to the defining symptoms of autism, a feature that has prompted a widespread use of the model in preclinical autism research.
A Gozzi, A Gozzi, A Gozzi, A Gozzi, A Gozzi, AA Turk, AC Stanfield, AE Dorr, Alberto Galbusera, Alessandro Gozzi, Allan V. Kalueff, Angelo Bifone, AY Hardan, AY Hardan, B Avants, BA Babineau, BB Avants, BB Avants, BB Avants, BU Meye, D Badaruddin, D Wahlsten, D Wahlsten, E Anagnostou, F Tovar-Moll, G Zaharchuk, H Ito, H Utsunomiya, J Ashburner, J Ellegood, JL Silverman, JL Silverman, JL Silverman, JL Whitwell, JM Mountz, JP Lerch, JP Lerch, KL Hyde, L Ferrari, L Ferrari, LK Paul, LK Paul, Luca Dodero, M Magnuson, M Sasaki, M Wohr, M Yang, M Yang, M Yang, M Zilbovicius, MA Just, Maria Luisa Scattoni, Mario Damiano, ME Vissers, ML Scattoni, ML Senjem, MM Haznedar, MM Haznedar, MS George, N Boddaert, N Hadjikhani, O Devinsky, R Adolphs, R Via E, RG Gonzalez, RJ Zatorre, S Mori, S Schobel, S Shen, SM Smith, Sotirios A. Tsaftsaris, SR Das, SS Moy, SS Moy, T Ohnishi, T Ren, TW Frazier, VJ Bolivar, WS Brown   +78 more
core   +10 more sources

Outbred CD1 mice are as suitable as inbred C57BL/6J mice in performing social tasks [PDF]

Neuroscience Letters, 2017
Inbred mouse strains have been used preferentially for behavioral testing over outbred counterparts, even though outbred mice reflect the genetic diversity in the human population better. Here, we compare the sociability of widely available outbred CD1 mice with the commonly used inbred C57BL/6J (C57) mice in the one-chamber social interaction test and
Lawrence S, Hsieh, John H, Wen, Laura, Miyares, Paul J, Lombroso, Angélique, Bordey   +4 more
openaire   +2 more sources

Genetic variability affects the skeletal response to immobilization in founder strains of the diversity outbred mouse population

Bone Reports, 2021
Mechanical unloading decreases bone volume and strength. In humans and mice, bone mineral density is highly heritable, and in mice the response to changes in loading varies with genetic background.
Michael A. Friedman, Abdullah Abood, Bhavya Senwar, Yue Zhang, Camilla Reina Maroni, Virginia L. Ferguson, Charles R. Farber, Henry J. Donahue   +7 more
doaj   +1 more source

Generation of live offspring from vitrified mouse oocytes of C57BL/6J strain. [PDF]

PLoS ONE, 2013
In mammals, unfertilized oocytes are one of the most available stages for cryopreservation because the cryopreserved oocytes can be used for assisted reproductive technologies, including in vitro fertilization (IVF) and intracytoplasmic sperm injection ...
Natsuki Kohaya, Katsuyoshi Fujiwara, Junya Ito, Naomi Kashiwazaki   +3 more
doaj   +1 more source