Results 1 to 10 of about 1,166 (102)

Deletion of the alpha-synuclein locus in a subpopulation of C57BL/6J inbred mice [PDF]

BMC Neuroscience, 2001
The presynaptic protein alpha-synuclein is involved in a range of neurodegenerative diseases. Here we analyze potential compensatory mechanisms in alpha-synuclein null mutant mice. Furthermore, the findings reveal problems that may be associated with inbred mouse strains.Expression profiling by cDNA array technology in a transgenic mouse model revealed
Specht, CG, Schoepfer, R
openaire   +5 more sources

Chronobiology of alcohol: Studies in C57BL/6J and DBA/2J inbred mice [PDF]

Physiology & Behavior, 2013
Human alcoholics display dramatic disruptions of circadian rhythms that may contribute to the maintenance of excessive drinking, thus creating a vicious cycle. While clinical studies cannot establish direct causal mechanisms, recent animal experiments have revealed bidirectional interactions between circadian rhythms and ethanol intake, suggesting that
Michael C. Fixaris, Alan M. Rosenwasser
openaire   +3 more sources

A companion to the preclinical common data elements for rodent genetic epilepsy models. A report of the TASK3‐WG1B: Paediatric and genetic models working group of the ILAE/AES joint translational TASK force

Epilepsia Open, EarlyView., 2022
Abstract Rodent models of epilepsy remain the cornerstone of research into the mechanisms underlying genetic epilepsy. Reproducibility of experiments using these rodent models, occurring across a diversity of laboratories and commercial vendors, remains an issue impacting the cost‐effectiveness and scientific rigor of the studies performed.
Massimo Mantegazza, Stėphane Auvin, Melissa Barker‐Haliski, Anna‐Maria Katsarou, Hana Kubova, Aristea S. Galanopoulou, Bridgette Semple, Christopher A. Reid   +7 more
wiley   +1 more source

Outbred CD1 mice are as suitable as inbred C57BL/6J mice in performing social tasks [PDF]

Neuroscience Letters, 2017
Inbred mouse strains have been used preferentially for behavioral testing over outbred counterparts, even though outbred mice reflect the genetic diversity in the human population better. Here, we compare the sociability of widely available outbred CD1 mice with the commonly used inbred C57BL/6J (C57) mice in the one-chamber social interaction test and
Angélique Bordey, John H. Wen, Laura Miyares, Lawrence S. Hsieh, Paul J. Lombroso   +4 more
openaire   +3 more sources

Alterations in microglial morphology concentrate in the habitual sleeping period of the mouse

Glia, Volume 71, Issue 2, Page 366-376, February 2023., 2023
Main Points We found regional differences of microglial morphology between the somatosensory cortex (SC), hippocampus (HC) and basal forebrain (BF). Cortical‐, but not HC‐ or BF microglial cell sizes negatively correlate with non‐REM sleep slow wave activity.
Sarah Katharina Steffens, Tarja Helena Stenberg, Henna‐Kaisa Margareta Wigren   +2 more
wiley   +1 more source

Sexing Bones: Improving Transparency of Sex Reporting to Address Bias Within Preclinical Studies

Journal of Bone and Mineral Research, Volume 38, Issue 1, Page 5-13, January 2023., 2023
ABSTRACT Despite knowledge that sexually dimorphic mechanisms regulate bone homeostasis, sex often remains unreported and unconsidered in preclinical experimental design. Failure to report sex could lead to inappropriate generalizations of research findings and less effective translation into clinical practice.
Aikta Sharma, Lysanne V Michels, Andrew A Pitsillides, Julie Greeves, Lillian I Plotkin, Valentina Cardo, Natalie A Sims, Claire E Clarkin   +7 more
wiley   +1 more source

Lipopolysaccharide‐Induced Bone Loss in Rodent Models: A Systematic Review and Meta‐Analysis

Journal of Bone and Mineral Research, Volume 38, Issue 1, Page 198-213, January 2023., 2023
ABSTRACT Osteoporosis has traditionally been characterized by underlying endocrine mechanisms, though evidence indicates a role of inflammation in its pathophysiology. Lipopolysaccharide (LPS), a component of gram‐negative bacteria that reside in the intestines, can be released into circulation and stimulate the immune system, upregulating bone ...
Kirsten N. Bott, Evelyn Feldman, Russell J. de Souza, Elena M. Comelli, Panagiota Klentrou, Sandra J. Peters, Wendy E. Ward   +6 more
wiley   +1 more source

CRISPR applications for Duchenne muscular dystrophy: From animal models to potential therapies

WIREs Mechanisms of Disease, Volume 15, Issue 1, January/February 2023., 2023
CRISPR‐Cas9 gene‐editing technology enables the rapid generation of animal models for Duchenne muscular dystrophy research and has potential to be developed as CRISPR therapy for the long lasting genetic correction of causal mutations. Abstract CRISPR gene‐editing technology creates precise and permanent modifications to DNA.
Yu C. J. Chey, Jayshen Arudkumar, Annemieke Aartsma‐Rus, Fatwa Adikusuma, Paul Q. Thomas   +4 more
wiley   +1 more source

Cysteine restriction‐specific effects of sulfur amino acid restriction on lipid metabolism

Aging Cell, Volume 21, Issue 12, December 2022., 2022
The proposed mechanism of CR‐specific effects of SAAR on adipose metabolism. (1) Due to the lack of Cys in SAAR diets, it imposes both MR and CR. CR specifically results in decreased biosynthesis of the tripeptide glutathione. (2) Lower hepatic glutathione increases the abundance of the transcription factor Nrf2, which translocates to the nucleus and ...
Sailendra N. Nichenametla, Dwight A. L. Mattocks, Diana Cooke, Vishal Midya, Virginia L. Malloy, Wilfredo Mansilla, Bente Øvrebø, Cheryl Turner, Nasser E. Bastani, Jitka Sokolová, Markéta Pavlíková, John P. Richie Jr., Anna K. Shoveller, Helga Refsum, Thomas Olsen, Kathrine J. Vinknes, Viktor Kožich, Gene P. Ables   +17 more
wiley   +1 more source

Bone Brittleness Varies with Genetic Background in A/J and C57BL/6J Inbred Mice [PDF]

Journal of Bone and Mineral Research, 2001
Abstract The contribution of genetic and environmental factors to variations in bone quality are understood poorly. We tested whether bone brittleness varies with genetic background using the A/J and C57BL/6J inbred mouse strains. Whole bone four-point bending tests revealed a 70% decrease in postyield deflection of A/J femurs compared ...
Karl J. Jepsen, Matthew L. Warman, Ying-Lung Lee, Douglas Pennington, Joseph H. Nadeau   +4 more
openaire   +3 more sources