Results 91 to 100 of about 208,784 (239)

The Impact of Toll‐Like Receptor 5 on Liver Function in Age‐Related Metabolic Disorders

Aging Cell, EarlyView.
Toll‐like receptor 5 (TLR5) deficiency accelerates age‐related metabolic disorders, leading to obesity, fatty liver, and cellular changes such as lipid accumulation in PMHs (hepatocytes) and activation of HSCs (hepatic stellate cells), which drive fibrosis.
Dong‐Hyun Kim, Hye Sun Go, Eun Jae Jeon, Thi Quynh Trang Nguyen, Da Yeon Kim, Hansung Park, Hyo‐Ji Eom, Sung Young Kim, Sang Chul Park, Kyung A Cho   +9 more
wiley   +1 more source

The effects of levetiracetam and a new 4-phenylpyrrolidone derivative GIZh-290 in a closed cross-maze in BALB/c and C57BL / 6 mice

Фармакокинетика и Фармакодинамика, 2017
The study was aimed to compare the psychopharmacological effects of 2 anticonvulsant drugs levetiracetam ((S)-2-(2-oxopyrrolidin-1-yl) butanamide) and the new compound, GIZh-290 (2-oxo-4-phenylpyrrolidine-1-yl) acetic acid) on behavioral spectra of ...
I. G. Kovalev, E. V. Vasileva, R. O. Bokov, R. M. Salimov, G. I. Kovalev   +4 more
doaj  

Development of a syngeneic mouse model of epithelial ovarian cancer

Journal of Ovarian Research, 2010
Background Most cases of ovarian cancer are epithelial in origin and diagnosed at advanced stage when the cancer is widely disseminated in the peritoneal cavity.
Quinn Bridget A, Xiao Fang, Bickel Laura, Martin Lainie, Hua Xiang, Klein-Szanto Andres, Connolly Denise C   +6 more
doaj   +1 more source

Energy Balance in Cell Phone Radiofrequency Radiation Exposed Mice and Rats [PDF]

arXiv, 2019
The National Toxicology Program exposed mice and rats to cell phone radiofrequency radiation. They observer cancers in male rats but not in male mice and different increases in body temperature between mice and rats using identical frequency and intensity exposures.
arxiv  

The Mitochondria‐Targeted Peptide Therapeutic Elamipretide Improves Cardiac and Skeletal Muscle Function During Aging Without Detectable Changes in Tissue Epigenetic or Transcriptomic Age

Aging Cell, EarlyView.
The effects of the mitochondria‐targeted peptide therapeutic elamipretide on age‐related muscle function were compared with its effects on molecular biomarkers of aging. It was found that elamipretide treatment partially reverses age‐related cardiac dysfunction and skeletal muscle weakness in mice without significantly affecting muscle epigenetic or ...
Wayne Mitchell, Gavin Pharaoh, Alexander Tyshkovskiy, Matthew Campbell, David J. Marcinek, Vadim N. Gladyshev   +5 more
wiley   +1 more source

Irf3 polymorphism alters induction of interferon beta in response to Listeria monocytogenes infection. [PDF]

PLoS Genetics, 2007
Genetic makeup of the host plays a significant role in the course and outcome of infection. Inbred strains of mice display a wide range of sensitivities to Listeria monocytogenes infection and thus serve as a good model for analysis of the effect of ...
Oleg Garifulin, Zanmei Qi, Haihong Shen, Sujatha Patnala, Michael R Green, Victor Boyartchuk   +5 more
doaj   +1 more source

Quantitative trait loci for tibial bone strength in C57BL/6J and C3H/HeJ inbred strains of mice [PDF]

Journal of Genetics, 2010
Three-point bending technology has been widely used in the measurement of bone strength. Quantitative trait loci (QTLs) for bone strength have been identified using mouse femurs. In this study, we investigate the use of mouse tibiae in identification of QTLs that regulate bone strength. Mouse tibiae were from a F(2) population derived from C57BL/6J (B6)
Jiao, F, Chiu, H, Jiao, Y, de, Rijk W, Li, X, Eckstein, E C, Beamer, W G, Gu, W   +7 more
openaire   +3 more sources

Aging‐Associated Vacuolation of Multi‐Ciliated Cells in the Distal Mouse Oviduct Reflects Unique Cell Identity and Luminal Microenvironment

Aging Cell, EarlyView.
Multi‐ciliated cells in the infundibulum and ampulla (INF/AMP) epithelium are vacuolated in aging. Unique cellular susceptibility of the INF/AMP epithelial population and aging‐associated decline in ovarian artery circulation, which supports the ovary and INF/AMP, contribute to this region‐specific vacuolation phenotype, as a consequence of a mildly ...
Keerthana Harwalkar, Nobuko Yamanaka, Alain S. Pacis, Selina Zhao, Katie Teng, Warwick Pitman, Mitaali Taskar, Vera Lynn, Alex Frances Thornton, Matthew J. Ford, Yojiro Yamanaka   +10 more
wiley   +1 more source

Delayed Clinical and Pathological Signs in Twitcher (Globoid Cell Leukodystrophy) Mice on a C57BL/6 × CAST/Ei Background

Neurobiology of Disease, 2002
Modifier genes may account for the phenotypic variability observed in the late-onset forms of globoid cell leukodystrophy (GCL) in humans. In order to begin a search for modifier genes, the effect of genetic background on the clinical and pathological ...
Sangita Biswas, Homigol Biesiada, Todd D. Williams, Steven M. LeVine   +3 more
doaj  

Normal spatial learning and improved spatial working memory in mice (mus musculus) lacking dopamine d4 receptors [PDF]

, 2001
Dopamine terminals in the hippocampus and prefrontal cortex modulate cognitive processes such as spatial learning and working memory. Because dopamine D4 receptors are expressed in these brain areas we have analyzed mutant mice lacking this receptor ...
Avale, Maria Elena, Falzone, Tomas Luis, Gelman, Diego Matias, Rubinstein, Marcelo   +3 more
core   +1 more source