Results 91 to 100 of about 212,073 (210)
Radiation-induced myeloid leukemia in murine models. [PDF]
, 2014 The use of radiation therapy is a cornerstone of modern cancer treatment. The number of patients that undergo radiation as a part of their therapy regimen is only increasing every year, but this does not come without cost.
Davoren, Michael +2 more
core +2 more sources
MYH6‐Cre Insertion Accelerates Cardiac Phenotype in Dystrophic D2‐mdx Mice
The FASEB Journal, Volume 39, Issue 14, 31 July 2025.D2.B10‐Dmdmdx/J dystrophic mice were crossed with Tg(myh6‐cre)1Jmk/J mice to create a cardiac‐specific Myh6‐cre (Cre+) promoter region on the D2‐mdx background. Cre+ dystrophic animals demonstrate worse right and left ventricular systolic function, which correlates with increased cardiac‐specific fibrosis and ultimately reduced survival.
India K. Hawkins +6 more
wiley +1 more source
Neurobiology of Disease, 2002 Modifier genes may account for the phenotypic variability observed in the late-onset forms of globoid cell leukodystrophy (GCL) in humans. In order to begin a search for modifier genes, the effect of genetic background on the clinical and pathological ...
Sangita Biswas +3 more
doaj
The FASEB Journal, Volume 39, Issue 13, 15 July 2025.This graphical abstract illustrates the NEBULA project, which examines combined high intensity preconditioning exercise as a countermeasure to microgravity. Mice underwent 3 weeks of training before 7–21 days of hindlimb unloading. After 7 days of simulated microgravity, trained mice showed positive adaptations related to the prevention of ...
Théo Fovet +18 more
wiley +1 more source
Advanced Science, Volume 12, Issue 26, July 10, 2025.Aortic dissection (AD) is accompanied by a decrease in CCDC80 in vascular smooth muscle cells (VSMCs). CCDC80 can interact with JAK2, and VSMC‐specific CCDC80 deficiency accelerates the progression of AD by activating the JAK2/STAT3 pathway involved in regulating the phenotype switching and function of VSMCs.
Qingqing Xiao +18 more
wiley +1 more source
European Journal of Immunology, Volume 55, Issue 7, July 2025.Ak2 deficiency leads to impaired development of T and B cells in mice, corresponding to impaired lymphopoiesis of reticular dysgenesis (AK2 deficiency) in humans. In contrast to the human pathophysiology, Ak2 deficiency is lethal in mice due to severe anaemia, and murine myelopoiesis is less affected.
Rebekka Waldmann +14 more
wiley +1 more source
ASN Neuro, 2011 We have previously shown that overexpression of the Glud1 (glutamate dehydrogenase 1) gene in neurons of C57BL/6 mice results in increased depolarization-induced glutamate release that eventually leads to selective neuronal injury and cell loss by 12 ...
Kevin N Hascup +9 more
doaj +1 more source
In utero ultrafine particulate matter exposure causes offspring pulmonary immunosuppression. [PDF]
, 2019 Early life exposure to fine particulate matter (PM) in air is associated with infant respiratory disease and childhood asthma, but limited epidemiological data exist concerning the impacts of ultrafine particles (UFPs) on the etiology of childhood ...
Chang, Richard C-A +15 more
core
Heterogeneity of the gut microbiome in mice : guidelines for optimizing experimental design [PDF]
, 2015 Targeted manipulation of the gut flora is increasingly being recognized as a means to improve human health. Yet, the temporal dynamics and intra- and interindividual heterogeneity of the microbiome represent experimental limitations, especially in human ...
Brinkman, Brigitta +4 more
core +1 more source
MedComm, Volume 6, Issue 7, July 2025.The graphical abstract emphasizes the complex nature of obesity, focusing on the interaction of behavioral, sociodemographic, genetic, and biomarker factors. It illustrates how lifestyle habits, demographics, and genetic predispositions influence obesity risk.
Ankita Awari +8 more
wiley +1 more source