Results 91 to 100 of about 310,492 (230)

Change in Recessive Lethal Alleles Frequency in Inbred Populations [PDF]

arXiv, 2013
In a population practicing consanguineous marriage, rare recessive lethal alleles (RRLA) have higher chances of affecting phenotypes. As inbreeding causes more homozygosity and subsequently more deaths, the loss of individuals with RRLA decreases the frequency of these alleles.
arxiv  

Phase Transition in Sexual Reproduction and Biological Evolution [PDF]

, 2008
Using Monte Carlo model of biological evolution we have discovered that populations can switch between two different strategies of their genomes' evolution; Darwinian purifying selection and complementing the haplotypes. The first one is exploited in the large panmictic populations while the second one in the small highly inbred populations. The choice
arxiv   +1 more source

Metabolic adaptations of three inbred strains of mice (C57BL/6, DBA/2, and 129T2) in response to a high-fat diet.

Journal of NutriLife, 2004
Although it is now becoming more evident that the strain of mouse used to generate genetically modified models for the study of endocrine disorders contributes to the ensuing phenotype, metabolic characterization of these common strains used to produce ...
A. Funkat, Christine M Massa, V. Jovanovska, J. Proietto, S. Andrikopoulos   +4 more
semanticscholar   +1 more source

Differential Levels of Glutamate Dehydrogenase 1 (GLUD1) in Balb/c and C57BL/6 Mice and the Effects of Overexpression of the Gene on Glutamate Release in Striatum

ASN Neuro, 2011
We have previously shown that overexpression of the Glud1 (glutamate dehydrogenase 1) gene in neurons of C57BL/6 mice results in increased depolarization-induced glutamate release that eventually leads to selective neuronal injury and cell loss by 12 ...
Kevin N Hascup, Xiaodong Bao, Erin R Hascup, Dongwei Hui, Wenhao Xu, Francois Pomerleau, Peter Huettl, Mary L Michaelis, Elias K Michaelis, Greg A Gerhardt   +9 more
doaj   +1 more source

Fast Computation of the Kinship Coefficients [PDF]

arXiv, 2016
For families, kinship coefficients are quantifications of the amount of genetic sharing between a pair of individuals. These coefficients are critical for understanding the breeding habits and genetic diversity of diploid populations. Historically, computations of the inbreeding coefficient were used to prohibit inbred marriages and prohibit breeding ...
arxiv  

Genetic analysis of cholesterol accumulation in inbred mice

Journal of Lipid Research, 2001
Genetic linkage analysis in the laboratory mouse identified chromosomal regions containing genes that contribute to cholesterol accumulation in the liver and plasma.
Margrit Schwarz, Daphne L. Davis, Bertrand R. Vick, David W. Russell   +3 more
doaj  

Early hippocampal high-amplitude rhythmic spikes predict post-traumatic epilepsy in mice

Frontiers in Neuroscience
Oscillations, a highly conserved brain function across mammalian species, play a pivotal role in both brain physiology and pathology. Traumatic brain injury (TBI) frequently results in subacute and chronic alterations in brain oscillations, which are ...
Tyler Shannon, Noah Levine, Rina Dirickson, Yuyan Shen, Christopher Cotter, Christopher Cotter, Noora Rajjoub, Julie Fitzgerald, Julie Fitzgerald, Fernando Pardo-Manuel de Villena, Fernando Pardo-Manuel de Villena, Olga Kokiko-Cochran, Olga Kokiko-Cochran, Olga Kokiko-Cochran, Bin Gu, Bin Gu   +15 more
doaj   +1 more source

Differences in the Flexibility of Switching Learning Strategies and CREB Phosphorylation Levels in Prefrontal Cortex, Dorsal Striatum, and Hippocampus in Two Inbred Strains of Mice

Frontiers in Behavioral Neuroscience, 2016
Flexibility in using different learning strategies was assessed in two different inbred strains of mice, the C57BL/6 and DBA/2 strains. Mice were trained sequentially in two different Morris water maze protocols that tested their ability to switch their ...
Woo-Hyun Cho, Jung-Soo Han
doaj   +1 more source

The pattern and distribution of deleterious mutations in maize [PDF]

arXiv, 2013
Most non-synonymous mutations are thought to be deleterious because of their effect on protein sequence. These polymorphisms are expected to be removed or kept at low frequency by the action of natural selection, and rare deleterious variants have been implicated as a possible explanation for the "missing heritability" seen in many studies of complex ...
arxiv  

Immunomodulation of salivary gland function due to cancer therapy

Oral Diseases, EarlyView.
Abstract Functional salivary glands (SG) are essential for maintaining oral health, and salivary dysfunction is a persistent major clinical challenge. Several cancer therapies also have off‐target effects leading to SG dysfunction. Recent advances highlight the role of SG immune populations in homeostasis, dysfunction and gland regeneration.
Ana C. Costa‐da‐Silva, Carlos U. Villapudua, Matthew P. Hoffman, Marit H. Aure   +3 more
wiley   +1 more source