Results 11 to 20 of about 209,711 (238)

Deletion of the alpha-synuclein locus in a subpopulation of C57BL/6J inbred mice [PDF]

BMC Neuroscience, 2001
Background The presynaptic protein α-synuclein is involved in a range of neurodegenerative diseases. Here we analyze potential compensatory mechanisms in α-synuclein null mutant mice.
Schoepfer Ralf, Specht Christian G
doaj   +5 more sources

Inter-individual Variability for High Fat Diet Consumption in Inbred C57BL/6 Mice [PDF]

Frontiers in Nutrition, 2019
Since inbred C57BL/6 mice are known to show inter-individual phenotypic variability for some traits, we tested the hypothesis that inbred C57BL/6 mice display a different tendency to consume a high fat (HF) diet.
Pablo N. De Francesco, María P. Cornejo, Franco Barrile, Guadalupe García Romero, Spring Valdivia, María F. Andreoli, Mario Perello   +6 more
doaj   +6 more sources

Chronobiology of alcohol: Studies in C57BL/6J and DBA/2J inbred mice [PDF]

Physiology & Behavior, 2013
Human alcoholics display dramatic disruptions of circadian rhythms that may contribute to the maintenance of excessive drinking, thus creating a vicious cycle. While clinical studies cannot establish direct causal mechanisms, recent animal experiments have revealed bidirectional interactions between circadian rhythms and ethanol intake, suggesting that
Michael C. Fixaris, Alan M. Rosenwasser
openaire   +3 more sources

Outbred CD1 mice are as suitable as inbred C57BL/6J mice in performing social tasks [PDF]

Neuroscience Letters, 2017
Inbred mouse strains have been used preferentially for behavioral testing over outbred counterparts, even though outbred mice reflect the genetic diversity in the human population better. Here, we compare the sociability of widely available outbred CD1 mice with the commonly used inbred C57BL/6J (C57) mice in the one-chamber social interaction test and
Angélique Bordey, John H. Wen, Laura Miyares, Lawrence S. Hsieh, Paul J. Lombroso   +4 more
openaire   +3 more sources

A companion to the preclinical common data elements for rodent genetic epilepsy models. A report of the TASK3‐WG1B: Paediatric and genetic models working group of the ILAE/AES joint translational TASK force

Epilepsia Open, EarlyView., 2022
Abstract Rodent models of epilepsy remain the cornerstone of research into the mechanisms underlying genetic epilepsy. Reproducibility of experiments using these rodent models, occurring across a diversity of laboratories and commercial vendors, remains an issue impacting the cost‐effectiveness and scientific rigor of the studies performed.
Massimo Mantegazza, Stėphane Auvin, Melissa Barker‐Haliski, Anna‐Maria Katsarou, Hana Kubova, Aristea S. Galanopoulou, Bridgette Semple, Christopher A. Reid   +7 more
wiley   +1 more source

Bone Brittleness Varies with Genetic Background in A/J and C57BL/6J Inbred Mice [PDF]

Journal of Bone and Mineral Research, 2001
Abstract The contribution of genetic and environmental factors to variations in bone quality are understood poorly. We tested whether bone brittleness varies with genetic background using the A/J and C57BL/6J inbred mouse strains. Whole bone four-point bending tests revealed a 70% decrease in postyield deflection of A/J femurs compared ...
Karl J. Jepsen, Matthew L. Warman, Ying-Lung Lee, Douglas Pennington, Joseph H. Nadeau   +4 more
openaire   +3 more sources

Development of a Mouse Model of Uremic Cardiomyopathy: Investigating the Impact of Chronic Kidney Disease on Cardiac Function and Signaling Pathway. [PDF]

FASEB J
Molecular changes in a mouse model of uremic cardiomyopathy. This model of 2,8‐DHA‐induced nephropathy in 129/Sv mice showed clinical features of uremic cardiomyopathy like reduced cardiac function and cardiac interstitial fibrosis and an unfavorable balance between protective and detrimental cardiac signaling.
Moellmann J, Glandien K, Klinkhammer BM, Wollenhaupt J, Noels H, Jankowski J, Lebherz C, Boor P, Lehrke M, Marx N.   +9 more
europepmc   +2 more sources

Quantitative Trait Loci That Determine BMD in C57BL/6J and 129S1/SvImJ Inbred Mice [PDF]

Journal of Bone and Mineral Research, 2006
Abstract BMD is highly heritable; however, little is known about the genes. To identify loci controlling BMD, we conducted a QTL analysis in a (B6 × 129) F2 population of mice. We report on additional QTLs and also narrow one QTL by combining the data from multiple crosses and through haplotype analysis.
Ishimori, N, Li, R, Walsh, K A, Korstanje, R, Rollins, J A, Petkov, P, Pletcher, M T, Wiltshire, T, Donahue, L R, Rosen, C J, Beamer, W G, Churchill, G A, Paigen, B   +12 more
openaire   +4 more sources

Agouti C57BL/6N embryonic stem cells for mouse genetic resources. [PDF]

, 2009
We report the characterization of a highly germline competent C57BL/6N mouse embryonic stem cell line, JM8. To simplify breeding schemes, the dominant agouti coat color gene was restored in JM8 cells by targeted repair of the C57BL/6 nonagouti mutation ...
Beier, David R, Bradley, Allan, Liang, Qi, Lloyd, Kent C, Moran, Jennifer L, Pettitt, Stephen J, Prosser, Haydn M, Rairdan, Xin Y, Skarnes, William C   +8 more
core   +1 more source

Placentophagia in Nonpregnant Nulliparous Mice: A Genetic Investigation [PDF]

, 1975
The genetic influence on the response of nonpregnant nulliparous mice to foster placenta was investigated. Two highly inbred strains (BALB/cBy and C57BL/6By), their F1 hybrids, a backcross generation, and seven recombinant-inbred strains derived from the
Eleftheriou, Basil E., Kristal, Dr. Mark B.   +1 more
core   +1 more source