Results 21 to 30 of about 329,438 (265)
Responses to ethanol in C57BL/6 versus C57BL/6 × 129 hybrid mice [PDF]
, 2012 Although genetic background alters responses to ethanol, there has not yet been a methodical quantification of differences in ethanol-related behaviors between inbred and hybrid mice commonly used in gene-targeting studies. Here, we compared C57BL/6NTac ×
Janak, Patricia H +3 more
core +2 more sources
Corticotropin-releasing factor receptors couple to multiple g-proteins to activate diverse intracellular signaling pathways in mouse hippocampus: role in neuronal excitability and associative learning [PDF]
, 2003 Corticotropin-releasing factor (CRF) exerts a key neuroregulatory control on stress responses in various regions of the mammalian brain, including the hippocampus.
Blank, T. (Thomas) +5 more
core +2 more sources
Placentophagia in Nonpregnant Nulliparous Mice: A Genetic Investigation [PDF]
, 1975 The genetic influence on the response of nonpregnant nulliparous mice to foster placenta was investigated. Two highly inbred strains (BALB/cBy and C57BL/6By), their F1 hybrids, a backcross generation, and seven recombinant-inbred strains derived from the
Eleftheriou, Basil E. +1 more
core +1 more source
Quantitative Trait Loci That Determine BMD in C57BL/6J and 129S1/SvImJ Inbred Mice [PDF]
Journal of Bone and Mineral Research, 2006 Abstract BMD is highly heritable; however, little is known about the genes. To identify loci controlling BMD, we conducted a QTL analysis in a (B6 × 129) F2 population of mice. We report on additional QTLs and also narrow one QTL by combining the data from multiple crosses and through haplotype analysis.
Ishimori, N +12 more
openaire +4 more sources
Journal of Neurochemistry, Volume 164, Issue 1, Page 6-28, January 2023., 2023 Brain endothelial cells (BECs), denoting the blood–brain barrier (BBB), can be specifically transduced both in vitro and in vivo following intravenous administration of the AAV‐BR1 vector, which onsets the synthesis of recombinant NPC2 protein from the BECs.
Charlotte Laurfelt Munch Rasmussen +8 more
wiley +1 more source
Agouti C57BL/6N embryonic stem cells for mouse genetic resources. [PDF]
, 2009 We report the characterization of a highly germline competent C57BL/6N mouse embryonic stem cell line, JM8. To simplify breeding schemes, the dominant agouti coat color gene was restored in JM8 cells by targeted repair of the C57BL/6 nonagouti mutation ...
Beier, David R +8 more
core +1 more source
Enhanced pup retrieval behaviour in a mouse model of polycystic ovary syndrome
Journal of Neuroendocrinology, Volume 34, Issue 12, December 2022., 2022 Virgin female mice show enhanced pup retrieval behaviour in a mouse model of polycystic ovary syndrome. When tested in an anxiogenic novel cage environment, prenatally androgenised (PNA) female mice rapidly retrieve and nest with pups, with most control females failing to complete the retireval task.
Zin Khant Aung +4 more
wiley +1 more source
Experimentation with Animals: A Key Aspect of the 3Rs. The Genetic Quality [PDF]
, 2019 The genetic quality of laboratory animals is essential for reproducibility of scientific research. Working with animals of certifiedgenetic quality is still a pending issue in Argentina due to the lack of routine genetic controls, of information on the ...
Castillo, Nadia Sabiela +4 more
core +1 more source
Empirical likelihood for estimating equations with missing values [PDF]
Annals of Statistics 2009, Vol. 37, No. 1, 490-517, 2009 We consider an empirical likelihood inference for parameters defined by general estimating equations when some components of the random observations are subject to missingness. As the nature of the estimating equations is wide-ranging, we propose a nonparametric imputation of the missing values from a kernel estimator of the conditional distribution of
arxiv +1 more source
Lifespan modulation in mice and the confounding effects of genetic background [PDF]
, 2014 We are currently in the midst of a revolution in ageing research, with several dietary, genetic and pharmacological interventions now known to modulate ageing in model organisms.
Mulvey, Lorna +2 more
core +1 more source