Results 61 to 70 of about 350,782 (186)
Agouti C57BL/6N embryonic stem cells for mouse genetic resources. [PDF]
, 2009 We report the characterization of a highly germline competent C57BL/6N mouse embryonic stem cell line, JM8. To simplify breeding schemes, the dominant agouti coat color gene was restored in JM8 cells by targeted repair of the C57BL/6 nonagouti mutation ...
Beier, David R +8 more
core +1 more source
A Novel Murine Model of Hemophagocytic Lymphohistiocytosis‐Like Inflammation in ZNFX1 Deficiency
European Journal of Immunology, Volume 56, Issue 2, February 2026.LCMV‐infected Znfx1‐deficient mice develop hemophagocytic lymphohistiocytosis (HLH)‐like immune dysregulation, mirroring key aspects of the immunopathology observed in ZNFX1‐deficient patients. ABSTRACT Hemophagocytic lymphohistiocytosis (HLH) is a severe inflammatory syndrome characterized by persistent activation of lymphocytes and macrophages ...
Diana Tintor +9 more
wiley +1 more source
Proximal Pulmonary Artery Stiffening as a Biomarker of Cardiopulmonary Aging
Aging Cell, Volume 25, Issue 2, February 2026.Mouse models revealed age‐associated increased circumferential stiffness of the proximal pulmonary artery that was associated with reorientation of collagen and decreased function of the lung and right ventricle. Age‐related transcriptional changes were indicative of senescence, ECM turnover, TGFβ signaling, and altered intercellular signaling among ...
Ruben De Man +22 more
wiley +1 more source
Ironing out the details: Untangling dietary iron and genetic background in diabetes [PDF]
, 2018 The search for genetic risk factors in type-II diabetes has been hindered by a failure to consider dietary variables. Dietary nutrients impact metabolic disease risk and severity and are essential to maintaining metabolic health.
Lawson, Heather A, Miranda, Mario A
core +2 more sources
Alcohol, Clinical and Experimental Research, Volume 50, Issue 2, February 2026.This review highlights the biphasic sipper model pioneered by Dr. Hank Samson's laboratory, which separates appetitive and consummatory behaviors in rodent ethanol self‐administration. Over two decades of research using this paradigm reveals that alcohol‐directed behaviors are dynamic, shaped by internal states, cues, and experience.
Olivia A. Colarusso, Jeffrey L. Weiner
wiley +1 more source
Placentophagia in Nonpregnant Nulliparous Mice: A Genetic Investigation [PDF]
, 1975 The genetic influence on the response of nonpregnant nulliparous mice to foster placenta was investigated. Two highly inbred strains (BALB/cBy and C57BL/6By), their F1 hybrids, a backcross generation, and seven recombinant-inbred strains derived from the
Eleftheriou, Basil E. +1 more
core +1 more source
Advanced Healthcare Materials, Volume 15, Issue 1, 9 January 2026.A novel blood‐brain barrier‐penetrating terpolymer nanoparticle to deliver brain‐derived neurotrophic factor (BDNF) for the treatment of Alzheimer's disease (AD) is designed. The BDNF‐TPN significantly enhances BDNF accumulation in the brain following intravenous injection, reduces apoptosis and neuroinflammation, thus promoting neuronal survival and ...
Lily Yi Li +8 more
wiley +1 more source
Nitrous Oxide: Mechanism of Its Antinociceptive Action [PDF]
, 1995 Nitrous oxide (N2O) is an anesthetic gas known to produce an analgesic effect at sub-anesthetic concentrations. This analgesic property of N2O can be clinically exploited in a broad range of conditions where pain relief is indicated.
Quock, Raymond M., Vaughn, Linda K.
core +1 more source
Age-Related Reference Intervals of the Main Biochemical and Hematological Parameters in C57BL/6J, 129SV/EV and C3H/HeJ Mouse Strains [PDF]
, 2008 BACKGROUND: Although the mouse is the animal model most widely used to study the pathogenesis and treatment of human diseases, reference values for biochemical parameters are scanty or lacking for the most frequently used strains.
CITO G. +6 more
core +3 more sources
ATF5‐Dependent GDF15 Expression Mediates Anesthesia‐Induced Neuroprotection Against Stroke
Advanced Science, Volume 13, Issue 3, 14 January 2026.Anesthesia‐induced preconditioning protects against perioperative stroke. By manipulating ATF5 in excitatory neurons, it is shown that anesthesia‐driven ATF5 upregulation activates the mitochondrial unfolded protein response (UPRmt) and elevates GDF15 expression.
Xianshu Ju +11 more
wiley +1 more source