Results 71 to 80 of about 329,438 (265)

Artesunate Inhibits Neointimal Hyperplasia by Promoting IRF4 Associated Macrophage Polarization

Advanced Science, EarlyView.
This study shows that macrophage interferon regulatory factor 4 (IRF4) improved arterial injury‐induced neointimal hyperplasia by promoting of M2 polarization via up‐regulating krüppel‐like factor 4 (KLF4) in rodent and nonhuman primate models. Notably, artesunate is identified as a potent inducer of IRF4 in macrophages, and proposed as a promising ...
Jinlin Miao, Yule Yong, Zhaohui Zheng, Kui Zhang, Wei Li, Jiayi Liu, Siyi Zhou, Juan‐juan Qin, Haoyang Sun, Yatao Wang, Xianghui Fu, Xing Luo, Siyu Chen, Zhi‐Gang She, Jingjing Cai, Ping Zhu   +15 more
wiley   +1 more source

ForestPMPlot: A Flexible Tool for Visualizing Heterogeneity Between Studies in Meta-analysis. [PDF]

, 2016
Meta-analysis has become a popular tool for genetic association studies to combine different genetic studies. A key challenge in meta-analysis is heterogeneity, or the differences in effect sizes between studies.
Eskin, Eleazar, Han, Buhm, Kang, Eun Yong, Li, Xiao, Park, Yurang, Segrè, Ayellet V   +5 more
core   +3 more sources

Quantitative analysis of mouse urine volatiles: in search of MHC-dependent differences. [PDF]

PLoS ONE, 2007
Genes of the major histocompatibility complex (MHC), which play a critical role in immune recognition, influence mating preference and other social behaviors in mice.
Frank Röck, Karl-Peter Hadeler, Hans-Georg Rammensee, Peter Overath   +3 more
doaj   +1 more source

The design of the time-of-flight system for MICE [PDF]

J.Phys.Conf.Ser.110:092004,2008, 2007
The international Muon Ionization Cooling Experiment (MICE) will carry out a systematic investigation of ionization cooling of a muon beam. As the emittance measurement will be done on a particle-by-particle basis, a sophisticated beam instrumentation is needed to measure particle coordinates and timing vs RF.
arxiv   +1 more source

System genetic analysis of intestinal cancer and periodontitis development as influenced by aging and diabesity using Collaborative Cross mice

Animal Models and Experimental Medicine, EarlyView.
It is increasingly recognized that young, chow‐fed inbred mice poorly model the complexity of human carcinogenesis in multiple respects. In humans, age and adiposity are the major risk factors for the majority of malignancies. Although the development of genetically engineered mouse models (GEMM) of cancer has recapitulated many aspects of human cancer,
Iqbal M. Lone, Osayd Zohud, Kareem Midlej, Charles Brenner, Fuad A. Iraqi   +4 more
wiley   +1 more source

Immune responses of different mouse strains after challenge with equivalent lethal doses of toxoplasma Gondii

Parasite, 2004
Most immunological studies that utilize different strains of inbred mice following T. gondii infection fail to compensate for differences in host susceptibility to the size of the parasite innoculum.
Lee Y.H., Kasper L.H.
doaj   +1 more source

Superovulation using the combined administration of inhibin antiserum and equine chorionic gonadotropin increases the number of ovulated oocytes in C57BL/6 female mice. [PDF]

PLoS ONE, 2015
Superovulation is a reproductive technique generally used to produce genetically engineered mice. Superovulation in mice involves the administration of equine chorionic gonadotropin (eCG) to promote follicle growth and then that of human chorionic ...
Toru Takeo, Naomi Nakagata
doaj   +1 more source

Glucose homeostasis and tissue transcript content of insulin signaling intermediates in four inbred strains of mice: C57BL/6, C57BLKS/6, DBA/2, and 129X1.

Endocrinology, 2004
Transgenic mice phenotypes generally depend on the background strains used in their creation. To examine the effects of genetic background on insulin signaling, we analyzed glucose homeostasis in four inbred strains of mice [C57BL/6 (B6), C57BLKS/6 (KLS),
H. Goren, R. Kulkarni, C. Kahn
semanticscholar   +1 more source

Discordant susceptibility of inbred C57BL/6 versus outbred CD1 mice to experimental fungal sepsis [PDF]

Cellular Microbiology, 2019
Individual susceptibility differences to fungal infection following invasive and/or immunosuppressive medical interventions are an important clinical issue. In order to explore immune response-related factors that may be linked to fungal infection susceptibility, we have compared the response of inbred C57BL/6J and outbred CD1 mouse strains to ...
Esther Carreras, María Velasco de Andrés, Marc Orta‐Mascaró, Inês T. Simões, Cristina Català, Oscar Zaragoza, Francisco Lozano   +6 more
openaire   +3 more sources

A new CRISPR‐mediated Apc knockout allele leads to pyloric gland adenoma‐like gastric polyps in mice with C57BL/6;FVB/N mixed background

Animal Models and Experimental Medicine, EarlyView.
The exon 16 of the mouse Apc gene was targeted with CRISPR/Cas9 system and a novel Apc knockout mouse model was generated by creating a frameshift mutation at codon 750 (ApcΔ750). The polyp number, polyp distribution and the overall survival of mice carrying the ApcΔ750 allele significantly differs between the F8‐FVB‐ApcΔ750 and F4‐B6;FVB‐ApcΔ750 mouse
Sarp Uzun, Özge Özcan, Ayşenur Gök, Aynur Işık, Sinem Bakır, Ayşen Günel‐Özcan, İlyas Onbaşılar, Aytekin Akyol   +7 more
wiley   +1 more source