Results 71 to 80 of about 208,900 (164)
Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 3, June 2025.ABSTRACT Background Deterioration of functional capacity mostly determinates frailty in older patients with cardiovascular disease (CVD). Elucidating the pathophysiological mechanisms of physical frailty is an important goal for improving functional health‐related outcomes. Our objective was the determination of the transcriptomic signature of physical
Omar Baritello +16 more
wiley +1 more source
In utero ultrafine particulate matter exposure causes offspring pulmonary immunosuppression. [PDF]
, 2019 Early life exposure to fine particulate matter (PM) in air is associated with infant respiratory disease and childhood asthma, but limited epidemiological data exist concerning the impacts of ultrafine particles (UFPs) on the etiology of childhood ...
Chang, Richard C-A +15 more
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Social dominance and wheel running in females of Djungarian hamster (Phodopus sungorus) [PDF]
, 2017 Wheel running is a behaviour that has a rewarding effect on animals. There are not numerous papers investigating potential relationships between social rank and wheel running in mammals kept in groups, and the majority of published researches ...
Błaszczyk, Bożena, Górecki, Marcin T
core +3 more sources
Journal of Neurochemistry, Volume 169, Issue 6, June 2025.Ndr2 participates in the T788/789 phosphorylation of the integrin β1 integrin subunit. Ndr2 deficiency reduces synaptic density, diminishes CA1 LTP, and impairs spatial memory. Activation of integrins restores the plasticity impairment of Ndr2 deficient mice. Ndr2 is involved in integrin‐dependent synapse formation and plasticity in the hippocampus CA1.
Del Angel +8 more
wiley +1 more source
Journal of General Virology, 1982 We have previously shown that adult C57BL/6 mice are relatively resistant to intraperitoneal (i.p.) infection with herpes simplex virus type 1 (HSV-1). Here we show that newborn mice of the strain C57BL/6 are highly susceptible to i.p. infection with HSV-1. Newborn C57BL/6 mice, in contrast to adult mice, did not develop natural killer cell activity in
Holger Kirchner +2 more
openaire +3 more sources
Nitrous Oxide: Mechanism of Its Antinociceptive Action [PDF]
, 1995 Nitrous oxide (N2O) is an anesthetic gas known to produce an analgesic effect at sub-anesthetic concentrations. This analgesic property of N2O can be clinically exploited in a broad range of conditions where pain relief is indicated.
Quock, Raymond M., Vaughn, Linda K.
core +1 more source
Development of outbred CD1 mouse colonies with distinct standardized gut microbiota profiles for use in complex microbiota targeted studies. [PDF]
, 2018 Studies indicate that the gut microbiota (GM) can significantly influence both local and systemic host physiologic processes. With rising concern for optimization of experimental reproducibility and translatability, it is essential to consider the GM in ...
Ericsson, Aaron C +7 more
core +1 more source
Effect of natural genetic variation on enhancer selection and function. [PDF]
, 2013 The mechanisms by which genetic variation affects transcription regulation and phenotypes at the nucleotide level are incompletely understood. Here we use natural genetic variation as an in vivo mutagenesis screen to assess the genome-wide effects of ...
Allison, KA +6 more
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Cancer vaccines: uses of HLA transgenic mice compared to genetically modified mice [PDF]
, 2008 Many tumor antigens have been identified that can be targeted by the immune system. Animal models that have been genetically modified to express human HLA molecules instead of their own MHC antigens have shown to be valuable in the discovery of peptides ...
McArdle, SE
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Assignment of the Human and Mouse Prion Protein Genes to Homologous Chromosomes [PDF]
, 1986 Purified preparations of scrapie prions contain one major macromolecule, designated prion protein (PrP). Genes encoding PrP are found in normal animals and humans but not within the infectious particles.
Blatt, Cila +13 more
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