Results 11 to 20 of about 686 (148)

A novel system for micron-scale analysis of energy deposition and response to low-dose radiation. [PDF]

Med Phys
Abstract Background Micrometer‐scale evaluation of energy deposition is important for radiation protection and therapy as well as for advancing knowledge of responses to radiation in materials and biological systems. Due to the stochastic nature of radiation interactions, there is significant variation in energy deposition in micrometer‐sized targets ...
Pasricha P, McNairn C, Mansour IR, Milligan K, Muir BR, Andrews JL, Cassol E, Chauhan V, Subedi S, Jirasek A, Murugkar S, Thomson RM.   +11 more
europepmc   +2 more sources

Measurement of microdosimetric spectra of high-LET particle beams using the ENCORE detector. [PDF]

Med Phys
Abstract Background Heavy ion radiotherapy offers distinct advantages over conventional treatments due to its superior dose distribution and enhanced biological effectiveness. However, the microdosimetric characteristics of high linear energy transfer (LET) ions, particularly near the Bragg peak, remain poorly characterized.
Hartzell S, Lopez-Saavedra E, Furutani KM, Almaraz-Calderon S, Baby LT, Wiedenhöver I, Beltran CJ.   +6 more
europepmc   +2 more sources

Small dose monitor based on silicon-carbide diodes for FLASH radiotherapy. [PDF]

Med Phys
Abstract Background The FLASH biological effect in radiotherapy has been observed to appear at ultra‐high dose rates UHDR (>$>$40 Gy/s), where the accurate dosimetry at such high rates is still a challenge. Purpose A new 4 ×$\times$ 4 array of SiC‐based detectors (1 mm diameter, 2.2 mm pitch) is proposed for dosimetry in UHDR, as well as the ...
Lopez Paz I, Fleta C, Henao Á, Heinrich S, Guardiola C.   +4 more
europepmc   +2 more sources

Exploring the potential of Raman micro-spectroscopy of radiochromic films for experimental microdosimetry. [PDF]

Med Phys
Background Micrometer‐scale dosimetry is crucial when estimating the energy deposited within micrometer‐scale biological targets exposed to low doses or high dose gradients. Raman micro‐spectroscopy read‐out of radiochromic films (RCFs) permits micrometer‐scale resolution; this presents a novel opportunity to explore its feasibility for experimental ...
McNairn C, Pasricha P, Milligan K, Mansour IR, Cassol E, Chauhan V, Andrews JL, Subedi S, Jirasek A, Muir BR, Thomson RM, Murugkar S.   +11 more
europepmc   +2 more sources

Equivalent relative biological effectiveness for cell survival and micronuclei formation: insights from a biophysical approach. [PDF]

Med Phys
Abstract Background Micronuclei (MN), which are chromosome fragments, are formed after exposure to ionizing radiation. Radiation‐induced MN is currently used as a quantitative indicator of the chromosomal aberrations detectable at a relatively early phase (e.g., within one cell‐cycle progression).
Matsuya Y, Saga R, Wang Y, Sato T.
europepmc   +2 more sources

Microdosimetry calculations in situ for clinically relevant photon sources and their correlation with the early DNA damage response. [PDF]

Med Phys
Abstract Background Radiobiological data suggests variations in relative biological effectiveness (RBE) between clinically used photon‐based sources. A microdosimetric formalism using Monte Carlo (MC) methods can mechanistically describe the photon RBE.
Dumančić M, Kalinowski J, Diaz-Martinez VD, Li J, Behmand B, DeCunha JM, Enger SA.   +6 more
europepmc   +2 more sources

Playing Hard with Si: Challenges and Opportunities for New Materials in Radiation Therapy Dosimetry. [PDF]

Adv Mater
Silicon has been a cornerstone material of radiation therapy dosimetry for many decades, providing somewhat unchallenged performance. However, there are caveats to its use, requiring complex designs and, often, correction factors to provide accurate measurements.
Cayley J, Filipev I, Davis JA, de Rover V, Cutajar D, Li E, Oborn BM, Petasecca M, Rosenfeld A, Lerch MLF.   +9 more
europepmc   +2 more sources

Human Skin Model From 15 GHz to 110 GHz. [PDF]

Bioelectromagnetics
ABSTRACT Compliance testing of wireless devices with absorbed power density (APD) limits requires body models that conservatively reproduce the absorption characteristics of human skin. Previous studies indicate that impedance‐matching effects are caused by the stratum corneum (SC) layer.
Christ A, Aeschbacher A, Tarigan B, Chitnis N, Fallahi A, Kühn S, Capstick M, Kuster N.   +7 more
europepmc   +2 more sources

Microdosimetry and Dose-Averaged LET Calculations of Protons in Liquid Water: A Novel Geant4-DNA Application

Frontiers in Physics, 2021
The spatial distribution of energy deposition events is an essential aspect in the determination of the radiobiological effects of ionizing radiation at the cellular level.
Anna Baratto-Roldán, Anna Baratto-Roldán, Alejandro Bertolet, Alejandro Bertolet, Giorgio Baiocco, Alejandro Carabe, Miguel Antonio Cortés-Giraldo   +6 more
doaj   +1 more source

Results of a Geant4 benchmarking study for bio-medical applications, performed with the G4-Med system. [PDF]

Med Phys
Abstract Background Geant4, a Monte Carlo Simulation Toolkit extensively used in bio‐medical physics, is in continuous evolution to include newest research findings to improve its accuracy and to respond to the evolving needs of a very diverse user community.
Arce P, Archer JW, Arsini L, Bagulya A, Bolst D, Brown JMC, Caccia B, Chacon A, Cirrone GAP, Cortés-Giraldo MA, Cutajar D, Cuttone G, Dondero P, Dotti A, Faddegon B, Fattori S, Fedon C, Guatelli S, Haga A, Incerti S, Ivanchenko V, Konstantinov D, Kyriakou I, Le A, Li Z, Maire M, Malaroda A, Mancini-Terracciano C, Mantero A, Michelet C, Milluzzo G, Nicolanti F, Novak M, Omachi C, Pandola L, Pensavalle JH, Perales Á, Perrot Y, Petringa G, Pozzi S, Quesada JM, Ramos-Méndez J, Romano F, Rosenfeld AB, Safavi-Naeini M, Sakata D, Sarmiento LG, Sasaki T, Sato Y, Sciuto A, Sechopoulos I, Simpson EC, Stanzani R, Tomal A, Toshito T, Tran HN, White C, Wright DH.   +57 more
europepmc   +2 more sources