Results 21 to 30 of about 1,709 (213)

A novel system for micron-scale analysis of energy deposition and response to low-dose radiation. [PDF]

Med Phys
Abstract Background Micrometer‐scale evaluation of energy deposition is important for radiation protection and therapy as well as for advancing knowledge of responses to radiation in materials and biological systems. Due to the stochastic nature of radiation interactions, there is significant variation in energy deposition in micrometer‐sized targets ...
Pasricha P, McNairn C, Mansour IR, Milligan K, Muir BR, Andrews JL, Cassol E, Chauhan V, Subedi S, Jirasek A, Murugkar S, Thomson RM.   +11 more
europepmc   +2 more sources

Measurement of microdosimetric spectra of high-LET particle beams using the ENCORE detector. [PDF]

Med Phys
Abstract Background Heavy ion radiotherapy offers distinct advantages over conventional treatments due to its superior dose distribution and enhanced biological effectiveness. However, the microdosimetric characteristics of high linear energy transfer (LET) ions, particularly near the Bragg peak, remain poorly characterized.
Hartzell S, Lopez-Saavedra E, Furutani KM, Almaraz-Calderon S, Baby LT, Wiedenhöver I, Beltran CJ.   +6 more
europepmc   +2 more sources

Cell survival comparison of proton, helium, and carbon ion interlaced minibeams in water phantom simulations. [PDF]

Med Phys
Abstract Background Radiotherapy is a key in cancer treatment, with particle therapy providing better tumor targeting and sparing healthy tissues. Particle Minibeam Radiotherapy (PMBT) integrates the advantages of spatial fractionation into particle radiotherapy by employing submillimeter‐sized beams, thus improving the therapeutic ratio by reducing ...
Rousseti A, Dollinger G, Reindl J.
europepmc   +2 more sources

Microdosimetry for hadron therapy: A state of the art of detection technology

Frontiers in Physics, 2022
The interest in hadron therapy is growing fast thanks to the latest technological advances in accelerators and delivery technologies, to the development of more and more efficient and comprehensive treatment planning tools, and due to its increasing ...
Gabriele Parisi, Gabriele Parisi, Francesco Romano, Giuseppe Schettino, Giuseppe Schettino   +4 more
doaj   +1 more source

Quantifying Radiosensitization of PSMA-Targeted Gold Nanoparticles on Prostate Cancer Cells at Megavoltage Radiation Energies by Monte Carlo Simulation and Local Effect Model

Pharmaceutics, 2022
Active targeting gold nanoparticles (AuNPs) are a very promising avenue for cancer treatment with many publications on AuNP mediated radiosensitization at kilovoltage (kV) photon energies.
Ryder M. Schmidt, Daiki Hara, Jorge D. Vega, Marwan B. Abuhaija, Wensi Tao, Nesrin Dogan, Alan Pollack, John C. Ford, Junwei Shi   +8 more
doaj   +1 more source

Overview of DISCOVER22 experiment in the framework of INFN-LNGS Cosmic Silence activity: challenges and improvements in underground radiobiology

Frontiers in Physics, 2023
One of the most intriguing and still pending questions in radiobiology is to understand whether and how natural environmental background radiation has shaped Life over millions of years of evolution on Earth.
Patrizia Morciano, Patrizia Morciano, Valentina Dini, Valentina Dini, Francesco Berardinelli, Francesco Berardinelli, Giorgio Baiocco, Giorgio Baiocco, Valeria Conte, Ion Udroiu, Ion Udroiu, Federica Barbato, Federica Barbato, Jessica Marinaccio, Jessica Marinaccio, Pasqualino Anello, Pasqualino Anello, Antonio Antoccia, Antonio Antoccia, Maria Antonella Tabocchini, Anna Selva, Stefania Canella, Anna Bianchi, Isabella Guardamagna, Isabella Guardamagna, Leonardo Lonati, Leonardo Lonati, Emanuele Scifoni, Matthias Laubenstein, Marco Balata, Francesco Ferella, Daniela Grifoni, Angelo Galante, Angelo Galante, Mauro Maccarrone, Mauro Maccarrone, Valentina Tirelli, Valentina Tirelli, Felicia Grasso, Massimo Sanchez, Massimo Sanchez, Antonella Sgura, Antonella Sgura   +42 more
doaj   +1 more source

Progress in 3D Silicon Radiation Detectors

Frontiers in Physics, 2022
In the past few years, there has been an increasing interest toward 3D silicon radiation detectors. Owing to their unique architecture, 3D detectors provide a remarkable radiation hardness at relatively low bias voltage (hence low power dissipation ...
Gian-Franco Dalla Betta, Gian-Franco Dalla Betta, Marco Povoli   +2 more
doaj   +1 more source

Small dose monitor based on silicon-carbide diodes for FLASH radiotherapy. [PDF]

Med Phys
Abstract Background The FLASH biological effect in radiotherapy has been observed to appear at ultra‐high dose rates UHDR (>$>$40 Gy/s), where the accurate dosimetry at such high rates is still a challenge. Purpose A new 4 ×$\times$ 4 array of SiC‐based detectors (1 mm diameter, 2.2 mm pitch) is proposed for dosimetry in UHDR, as well as the ...
Lopez Paz I, Fleta C, Henao Á, Heinrich S, Guardiola C.   +4 more
europepmc   +2 more sources

Microdosimetry and Dose-Averaged LET Calculations of Protons in Liquid Water: A Novel Geant4-DNA Application

Frontiers in Physics, 2021
The spatial distribution of energy deposition events is an essential aspect in the determination of the radiobiological effects of ionizing radiation at the cellular level.
Anna Baratto-Roldán, Anna Baratto-Roldán, Alejandro Bertolet, Alejandro Bertolet, Giorgio Baiocco, Alejandro Carabe, Miguel Antonio Cortés-Giraldo   +6 more
doaj   +1 more source

Confocal Microscopy Improves 3D Microdosimetry Applied to Nanoporation Experiments Targeting Endoplasmic Reticulum

Frontiers in Bioengineering and Biotechnology, 2020
In the last years, microdosimetric numerical models of cells including intracellular compartments have been proposed, aiming to investigate the poration induced by the application of nanosecond pulsed electric fields (nsPEFs). A limitation of such models
Annalisa De Angelis, Annalisa De Angelis, Agnese Denzi, Caterina Merla, Frank M. Andre, Lluis M. Mir, Francesca Apollonio, Francesca Apollonio, Micaela Liberti, Micaela Liberti   +9 more
doaj   +1 more source