Results 21 to 30 of about 686 (148)

Confocal Microscopy Improves 3D Microdosimetry Applied to Nanoporation Experiments Targeting Endoplasmic Reticulum

Frontiers in Bioengineering and Biotechnology, 2020
In the last years, microdosimetric numerical models of cells including intracellular compartments have been proposed, aiming to investigate the poration induced by the application of nanosecond pulsed electric fields (nsPEFs). A limitation of such models
Annalisa De Angelis, Annalisa De Angelis, Agnese Denzi, Caterina Merla, Frank M. Andre, Lluis M. Mir, Francesca Apollonio, Francesca Apollonio, Micaela Liberti, Micaela Liberti   +9 more
doaj   +1 more source

A Novel Hybrid Microdosimeter for Radiation Field Characterization Based on the Tissue Equivalent Proportional Counter Detector and Low Gain Avalanche Detectors Tracker: A Feasibility Study

Frontiers in Physics, 2021
In microdosimetry, lineal energies y are calculated from energy depositions ϵ inside the microdosimeter divided by the mean chord length, whose value is based on geometrical assumptions on both the detector and the radiation field.
M. Missiaggia, M. Missiaggia, M. Missiaggia, E. Pierobon, M. Castelluzzo, A. Perinelli, F. Cordoni, F. Cordoni, M. Centis Vignali, G. Borghi, G. Borghi, E. V. Bellinzona, E. V. Bellinzona, E. Scifoni, F. Tommasino, F. Tommasino, V. Monaco, L. Ricci, L. Ricci, M. Boscardin, M. Boscardin, Chiara La Tessa, Chiara La Tessa   +22 more
doaj   +1 more source

Silicon 3D Microdosimeters for Advanced Quality Assurance in Particle Therapy

Applied Sciences, 2021
The Centre for Medical Radiation Physics introduced the concept of Silicon On Insulator (SOI) microdosimeters with 3-Dimensional (3D) cylindrical sensitive volumes (SVs) mimicking the dimensions of cells in an array. Several designs of high-definition 3D
Linh T. Tran, David Bolst, Benjamin James, Vladimir Pan, James Vohradsky, Stefania Peracchi, Lachlan Chartier, Emily Debrot, Susana Guatelli, Marco Petasecca, Michael Lerch, Dale Prokopovich, Željko Pastuović, Marco Povoli, Angela Kok, Taku Inaniwa, Sung Hyun Lee, Naruhiro Matsufuji, Anatoly B. Rosenfeld   +18 more
doaj   +1 more source

Fluorescent nuclear track detectors for alpha radiation microdosimetry

Radiation Oncology, 2018
Background While alpha microdosimetry dates back a couple of decades, the effects of localized energy deposition of alpha particles are often still unclear since few comparative studies have been performed.
J. J. M. Kouwenberg, H. T. Wolterbeek, A. G. Denkova, A. J. J. Bos   +3 more
doaj   +1 more source

Lineal Energy of Proton in Silicon by a Microdosimetry Simulation

Applied Sciences, 2021
Single event upset, or Single Event Effect (SEE) is increasingly important as semiconductor devices are entering into nano-meter scale. The Linear Energy Transfer (LET) concept is commonly used to estimate the rate of SEE.
Yueh Chiang, Cher Ming Tan, Chuan-Jong Tung, Chung-Chi Lee, Tsi-Chian Chao   +4 more
doaj   +1 more source

Predicting the Biological Effects of Human Salivary Gland Tumour Cells for Scanned ⁴He-, ¹²C-, ¹⁶O-, and ²⁰Ne-Ion Beams Using an SOI Microdosimeter

Applied Sciences, 2022
Experimental microdosimetry along with the microdosimetric kinetic (MK) model can be utilized to predict the biological effects of ions. To predict the relative biological effectiveness (RBE) of ions and the survival fraction (SF) of human salivary gland
Sung Hyun Lee, Kota Mizushima, Shunsuke Yonai, Shinnosuke Matsumoto, Hideyuki Mizuno, Taku Nakaji, Ryosuke Kohno, Yoshiyuki Iwata, Toshiyuki Shirai, Vladimir Pan, Angela Kok, Marco Povoli, Linh T. Tran, Anatoly B. Rosenfeld, Masao Suzuki, Taku Inaniwa   +15 more
doaj   +1 more source

Impact of intracellular radionuclide distribution in a Monte Carlo biophysical 3D multi-cellular model for targeted alpha therapy. [PDF]

Med Phys
Abstract Background To understand and predict the therapeutic efficacy of targeted alpha therapy (TAT), nano‐ and microdosimetry are needed to consider the very heterogeneous dose deposition at cellular and subcellular levels. Purpose The objective of this study is to theoretically evaluate the importance of cell internalization of alpha‐emitters on ...
Levrague V, Alcocer-Ávila M, Otmani SL, Maigne L, Testa E, Beuve M, Delorme R.   +6 more
europepmc   +2 more sources

Microdosimetric Investigation and a Novel Model of Radiosensitization in the Presence of Metallic Nanoparticles

Pharmaceutics, 2021
Auger cascades generated in high atomic number nanoparticles (NPs) following ionization were considered a potential mechanism for NP radiosensitization. In this work, we investigated the microdosimetric consequences of the Auger cascades using the theory
Huagang Yan, David J. Carlson, Ramin Abolfath, Wu Liu   +3 more
doaj   +1 more source

A Model for Estimating Dose-Rate Effects on Cell-Killing of Human Melanoma after Boron Neutron Capture Therapy

Cells, 2020
Boron neutron capture therapy (BNCT) is a type of radiation therapy for eradicating tumor cells through a 10B(n,α)7Li reaction in the presence of 10B in cancer cells.
Yusuke Matsuya, Hisanori Fukunaga, Motoko Omura, Hiroyuki Date   +3 more
doaj   +1 more source

Simultaneous Measurements of Dose and Microdosimetric Spectra in a Clinical Proton Beam Using a scCVD Diamond Membrane Microdosimeter

Sensors, 2021
A single crystal chemical vapor deposition (scCVD) diamond membrane-based microdosimetric system was used to perform simultaneous measurements of dose profile and microdosimetric spectra with the Y1 proton passive scattering beamline of the Center of ...
Oluwasayo Loto, Izabella Zahradnik, Amelia Maia Leite, Ludovic De Marzi, Dominique Tromson, Michal Pomorski   +5 more
doaj   +1 more source