Results 11 to 20 of about 870,242 (177)

Technical note on cytokinesis-arrested binucleated cell and micronucleus assay

Journal of Radiation and Cancer Research, 2017
Conventionally, many biomarkers are being in use as a measure to genotoxicity in occupational exposure to chemicals, pesticides, radiation, and drug screening. Of which, the micronucleus assay is a preferred choice for many of those applications owing to
Karthik Kanagaraj, Venkateswarlu Raavi, Shangamithra Visweswaran, Tamizh Gnanasekaran Selvan, Shanmugapriya Dhanashekaran, Venkatachalam Perumal   +5 more
doaj   +2 more sources

Validation of the micronucleus-centromere assay for biological dosimetry

Genetics and Molecular Biology, 2000
The micronucleus assay is frequently used for purposes of biological dosimetry. Due to high interindividual variability in the spontaneous frequency of micronuclei, its sensitivity in the low dose region is poor.
Wojcik A., Kowalska M., Bouzyk E., Buraczewska I., Kobialko G., Jarocewicz N., Szumiel I.   +6 more
doaj   +1 more source

Heritability of chromosomal radiosensitivity in breast cancer patients: A pilot study with the lymphocyte micronucleus assay

, 2000
Of breast cancer patients, 30% are sensitive in a lymphocyte assay of radiation-induced chromosome damage (micronucleus induction) compared with 10% of healthy controls.
Roberts, S. A., Bulman, B., Burrill, W., Scott, D., Barber, J. B P, Bulman, Barbara, Barber, James B P, Scott, David, Burrill, Wayne, Roberts, Stephen A, W. Burrill, J. B. P. Barber, S. A. Rob   +10 more
core   +6 more sources

Salivary ki-67 and micronucleus assay as potential biomarker of OSCC in betel nut chewers

Journal of Indian Academy of Oral Medicine and Radiology, 2021
Introduction: Oral cancer is often associated with various factors, such as betel nut consumption, which usually causes specific premalignant lesions. The most common oral cancer is oral squamous cell carcinoma (OSCC) which has a low 5-year survivor rate
Maulina Triani, Haris B Widodo, Dody Novrial, Dewi Agustina, Gita Nawangtantrini   +4 more
doaj   +1 more source

Chronic exposure effect study on Ramsar high background natural radiation areas (HBNRAs) residents using micronucleus assay [PDF]

مجله علوم و فنون هسته‌ای, 2023
The effect of chronic exposure on Ramsar HBNRAs inhabitants' health was studied using Cytokinesis Blocked Micronucleus (CBMN) Assay. The results showed a significant difference (P
F. Abbasi Siar, P. Abdolmaleki, A. Haeri, M. Hosseini Pooya   +3 more
doaj   +1 more source

An Automated, Single Cell Quantitative Imaging Microscopy Approach to Assess Micronucleus Formation, Genotoxicity and Chromosome Instability

Cells, 2020
Micronuclei are small, extranuclear bodies that are distinct from the primary cell nucleus. Micronucleus formation is an aberrant event that suggests a history of genotoxic stress or chromosome mis-segregation events.
Chloe C. Lepage, Laura L. Thompson, Bradley Larson, Kirk J. McManus   +3 more
doaj   +1 more source

EFFECT OF RESVERATROL ON GENOMIC STABILITY IN FANCONI ANEMIA [PDF]

Journal of Environmental Science, 2019
Fanconi anemia is a genetically and phenotypically heterogenous disorder characterized by DNA repair deficiency and telomeric erosion. Different antioxidants have been assessed to regain the chromosomal stability in Fanconi anemia, among those is the ...
Peter S. Fahmy, Mostafa H. Ragab, Amal M. Mohamed, Maha M. Eid, Ghada Y. El- Kamah   +4 more
doaj   +1 more source

Micronucleus Assay in Environmental Biomonitoring

Folia Veterinaria, 2020
Nowadays many chemicals are widely used in agriculture to ensure high crop yields or in veterinary/human medicine to cure diseases. After their improper usage they may contaminate the environment, persist in it and adversely affect both the target and/or
Michalová V., Galdíková M., Holečková B., Koleničová S., Schwarzbacherová V.   +4 more
doaj   +1 more source

Absence of genotoxic effects of the chalcone (E)-1-(2-hydroxyphenyl)-3-(4-methylphenyl)-prop-2-en-1-one) and its potential chemoprevention against DNA damage using in vitro and in vivo assays. [PDF]

PLoS ONE, 2017
The chalcone (E)-1-(2-hydroxyphenyl)-3-(4-methylphenyl)-prop-2-en-1-one), or 2HMC, displays antileishmanial, antimalarial, and antioxidant activities. The aim of this study was to investigate the cytotoxic, genotoxic, mutagenic, and protective effects of
Débora Cristina da Silva Lima, Camila Regina do Vale, Jefferson Hollanda Véras, Aline Bernardes, Caridad Noda Pérez, Lee Chen-Chen   +5 more
doaj   +1 more source

LiCoO2 particles used in Li-ion batteries induce primary mutagenicity in lung cells via their capacity to generate hydroxyl radicals

Particle and Fibre Toxicology, 2020
Background Li-ion batteries (LIB) are used in most portable electronics. Among a wide variety of materials, LiCoO2 (LCO) is one of the most used for the cathode of LIB.
Violaine Sironval, Vittoria Scagliarini, Sivakumar Murugadoss, Maura Tomatis, Yousof Yakoub, Francesco Turci, Peter Hoet, Dominique Lison, Sybille van den Brule   +8 more
doaj   +1 more source