Results 11 to 20 of about 16,085 (225)

Technical note on cytokinesis-arrested binucleated cell and micronucleus assay

Journal of Radiation and Cancer Research, 2017
Conventionally, many biomarkers are being in use as a measure to genotoxicity in occupational exposure to chemicals, pesticides, radiation, and drug screening. Of which, the micronucleus assay is a preferred choice for many of those applications owing to
Karthik Kanagaraj, Venkateswarlu Raavi, Shangamithra Visweswaran, Tamizh Gnanasekaran Selvan, Shanmugapriya Dhanashekaran, Venkatachalam Perumal   +5 more
doaj   +2 more sources

CYTOKINESIS-BLOCK MICRONUCLEUS ASSAY IN HUMAN GLIOMA CELLS EXPOSED TO RADIATION

Image Analysis and Stereology, 2011
Biological tests are efficient in reflecting the biological influences of several types of generally harmful exposures. The micronucleus assay is widely used in genotoxicity studies or studies on genomic damage in general.
Jerzy Slowinski, Grazyna Bierzynska-Macyszyn, Urszula Mazurek, Maria Widel, Malgorzata Latocha, Monika Stomal, Miroslaw Snietura, Ryszard Mrowka   +7 more
doaj   +3 more sources

The Micronucleus Assay on Cryopreserved Whole Blood

Journal of Visualized Experiments
The in vitro cytokinesis-block micronucleus (CBMN) assay is a widely used technique in radiobiology research, biological dosimetry, genotoxicity studies, and in vitro radiosensitivity testing. This cytogenetic method is based on the detection of micronuclei in binucleated cells resulting from chromosomal fragments lagging during cell division.
Dayal, Renu, Beyls, Elien, Vral, Anne, Baeyens, Ans   +3 more
openaire   +3 more sources

The micronucleus assay in radiation accidents.

Annali dell'Istituto superiore di sanita, 2009
The cytokinesis-block micronucleus assay in peripheral blood lymphocytes is a standardised and validated technique for biodosimetry. Automated scoring of micronuclei allows large scale applications as in population triage in case of radiation accidents or malevolent use of radioactive sources.
Thierens, Hubert, Vral, Anne
openaire   +3 more sources

Validation of the micronucleus-centromere assay for biological dosimetry

Genetics and Molecular Biology, 2000
The micronucleus assay is frequently used for purposes of biological dosimetry. Due to high interindividual variability in the spontaneous frequency of micronuclei, its sensitivity in the low dose region is poor.
Wojcik A., Kowalska M., Bouzyk E., Buraczewska I., Kobialko G., Jarocewicz N., Szumiel I.   +6 more
doaj   +1 more source

Cytokinesis-block micronucleus cytome assay [PDF]

Nature Protocols, 2007
The cytokinesis-block micronucleus cytome assay is a comprehensive system for measuring DNA damage, cytostasis and cytotoxicity. DNA damage events are scored specifically in once-divided binucleated (BN) cells and include (a) micronuclei (MNi), a biomarker of chromosome breakage and/or whole chromosome loss, (b) nucleoplasmic bridges (NPBs), a ...
Fenech, M., Michael Fenech
openaire   +4 more sources

Micronucleus Assay: The State of Art, and Future Directions [PDF]

International Journal of Molecular Sciences, 2020
Iwona Buraczewska, Marcin Kruszewski, Kruszewski Marcin   +2 more
exaly   +2 more sources

Genotoxicity of Di (2-ethyl hexyl) phthalate

Zhongguo shipin weisheng zazhi, 2022
ObjectiveTo assess the genotoxicity of Di（2-ethylhexyl） phthalate （DEHP）.MethodsA series of guideline-compliant assays were performed to evaluate mutagenicity， chromosomal or DNA damage of DEHP， including Ames test， in vitro mammalian chromosome ...
LI Juntao, LI Wenxue, ZHANG Yan, YANG Guangyu, ZHUANG Runxuan, ZHANG Xiaojun, YANG Hui, ZHANG Bo, ZHU Wei, YANG Ying   +9 more
doaj   +1 more source

Chronic exposure effect study on Ramsar high background natural radiation areas (HBNRAs) residents using micronucleus assay [PDF]

مجله علوم و فنون هسته‌ای, 2023
The effect of chronic exposure on Ramsar HBNRAs inhabitants' health was studied using Cytokinesis Blocked Micronucleus (CBMN) Assay. The results showed a significant difference (P
F. Abbasi Siar, P. Abdolmaleki, A. Haeri, M. Hosseini Pooya   +3 more
doaj   +1 more source

Salivary ki-67 and micronucleus assay as potential biomarker of OSCC in betel nut chewers

Journal of Indian Academy of Oral Medicine and Radiology, 2021
Introduction: Oral cancer is often associated with various factors, such as betel nut consumption, which usually causes specific premalignant lesions. The most common oral cancer is oral squamous cell carcinoma (OSCC) which has a low 5-year survivor rate
Maulina Triani, Haris B Widodo, Dody Novrial, Dewi Agustina, Gita Nawangtantrini   +4 more
doaj   +1 more source