Results 21 to 30 of about 16,085 (225)
Cells, 2020 Micronuclei are small, extranuclear bodies that are distinct from the primary cell nucleus. Micronucleus formation is an aberrant event that suggests a history of genotoxic stress or chromosome mis-segregation events.
Chloe C. Lepage +3 more
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Reflections on the development of micronucleus assays [PDF]
Mutagenesis, 2010 These are personal reflections on the development of methods to use micronuclei as a measure of genetic damage and their use in research and in toxicology by four people who have been intimately involved with this work, a personal rather than a comprehensive history. About 6000 papers have been published using such methods in many tissues in vivo or in
John A, Heddle +3 more
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EFFECT OF RESVERATROL ON GENOMIC STABILITY IN FANCONI ANEMIA [PDF]
Journal of Environmental Science, 2019 Fanconi anemia is a genetically and phenotypically heterogenous disorder characterized by DNA repair deficiency and telomeric erosion. Different antioxidants have been assessed to regain the chromosomal stability in Fanconi anemia, among those is the ...
Peter S. Fahmy +4 more
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Performance of HepaRG and HepG2 cells in the high-throughput micronucleus assay for in vitro genotoxicity assessment [PDF]
Journal of Toxicology and Environmental Health - Part A: Current Issues, 2020 Xiaoqing Guo +2 more
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Absence of genotoxic effects of the chalcone (E)-1-(2-hydroxyphenyl)-3-(4-methylphenyl)-prop-2-en-1-one) and its potential chemoprevention against DNA damage using in vitro and in vivo assays. [PDF]
PLoS ONE, 2017 The chalcone (E)-1-(2-hydroxyphenyl)-3-(4-methylphenyl)-prop-2-en-1-one), or 2HMC, displays antileishmanial, antimalarial, and antioxidant activities. The aim of this study was to investigate the cytotoxic, genotoxic, mutagenic, and protective effects of
Débora Cristina da Silva Lima +5 more
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Particle and Fibre Toxicology, 2020 Background Li-ion batteries (LIB) are used in most portable electronics. Among a wide variety of materials, LiCoO2 (LCO) is one of the most used for the cathode of LIB.
Violaine Sironval +8 more
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New direct contact approach to evaluate soil genotoxicity using the Vicia faba micronucleus test. [PDF]
, 2009 A method to assess micronucleus (MN) induction in Vicia faba roots by direct contact exposure to a solid matrix was developed. The procedure comprised a 5-d germination period, as in the well-known method using aqueous extracts.
Cecchi, M. +6 more
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Micronucleus assay in aquatic animals [PDF]
Mutagenesis, 2010 Aquatic pollutants produce multiple consequences at organism, population, community and ecosystem level, affecting organ function, reproductive status, population size, species survival and thus biodiversity. Among these, carcinogenic and mutagenic compounds are the most dangerous as their effects may exert a damage beyond that of individual and may be
Claudia, Bolognesi, Makoto, Hayashi
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Buccal Micronucleus Cytome Assay in Sickle Cell Disease [PDF]
Journal of Clinical and Diagnostic Research, 2016 Introduction: Sickle Cell Anaemia (SCA) is a commonly inherited blood disorder preceded by episodes of pain, chronic haemolytic anaemia and severe infections.
Mallika Bokka Sri Satya Naga +5 more
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Toxicology Reports, 2022 Non-clinical in vitro studies were conducted to investigate the characteristics of extracts from tobacco free nicotine pouches alongside a reference snus product and/or 1R6F reference cigarette.
Jacqueline Miller-Holt +5 more
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