Results 11 to 20 of about 13,742,305 (307)

Biomonitoring of the genotoxic potential of aqueous extracts of soils and bottom ash resulting from municipal solid waste incineration, using the comet and micronucleus tests on amphibian (Xenopus laevis) larvae and bacterial assays (MutatoxR and Ames tests) [PDF]

Science of the Total Environment, 2006
The management of contaminated soils and wastes is a matter of considerable human concern. The present study evaluates the genotoxic potential of aqueous extracts of two soils (leachates) and of bottom ash resulting from municipal solid waste ...
Devaux, Alain, Ferrier, Vincent, Gauthier, Laury, Jourdain, Marie-José, Mailhes, Corinne, Mouchet, Florence, Triffault, Gaëlle   +6 more
core   +3 more sources

Mutagenic effects of tributyltin and inorganic lead (Pb II) on the fish H. malabaricus as evaluated using the comet assay and the piscine micronucleus and chromosome aberration tests

Genetics and Molecular Biology, 2004
Genotoxicity studies on toxic metals and their organic compounds are very important, especially so in the investigation of the effects of these compounds on the aquatic environments where they tend to accumulate.
Marcos Vinícius M. Ferraro, Alberto Sérgio Fenocchio, Mario Sérgio Mantovani, Ciro de Oliveira Ribeiro, Marta Margarete Cestari   +4 more
doaj   +2 more sources

Is Micronucleus Assay a Suitable Biomarker for Evaluating the Cancer Risk in Professionals Exposed to Antineoplastic Drugs? A Systematic Review. [PDF]

J Appl Toxicol
ABSTRACT The widespread use of antineoplastic drugs in cancer treatment has led to significant concerns regarding the potential health risks posed to healthcare professionals involved in the preparation, administration, and handling of these chemical compounds, including genotoxicity.
Pinto TG, da Silva Avanci L, de Aguiar GC, de Souza DV, Cury PR, Renno ACM, Ribeiro DA.   +6 more
europepmc   +2 more sources

Giemsa versus acridine orange staining in the fish micronucleus assay and validation for use in water quality monitoring [PDF]

, 2011
This study concerns a comparative analysis of the acridineorange and Giemsastaining procedures for the fish erythrocyte micronucleusassay. The goal was to optimize the assay in the context of field watermonitoring. Fish (Carassius carassius) were exposed
Gauthier, Laury, Jean, Séverine, Laplanche, Christophe, Merlina, Georges, Pinelli, Eric, Polard, Thierry   +5 more
core   +2 more sources

Effect of the metabolic capacity in rat liver S9 on the positive results of in vitro micronucleus tests.

Journal of Toxicological Sciences, 2019
A high incidence of positive results is obtained with in vitro genotoxicity tests, which do not correlate with the in vivo negative results in many cases.
Yuki Kishino, T. Hasegawa, Shingo Arakawa, Yukari Shibaya, T. Yamoto, K. Mori   +5 more
semanticscholar   +1 more source

Validation of the 3D reconstructed human skin micronucleus (RSMN) assay: an animal-free alternative for following-up positive results from standard in vitro genotoxicity assays

Mutagenesis, 2021
In vitro test batteries have become the standard approach to determine the genotoxic potential of substances of interest across industry sectors. While useful for hazard identification, standard in vitro genotoxicity assays in 2D cell cultures have ...
S. Pfuhler, T. Downs, N. Hewitt, S. Hoffmann, G. Mun, G. Ouedraogo, Shambhu K. Roy, R. Curren, M. Aardema   +8 more
semanticscholar   +1 more source

Salivary ki-67 and micronucleus assay as potential biomarker of OSCC in betel nut chewers

Journal of Indian Academy of Oral Medicine and Radiology, 2021
Introduction: Oral cancer is often associated with various factors, such as betel nut consumption, which usually causes specific premalignant lesions. The most common oral cancer is oral squamous cell carcinoma (OSCC) which has a low 5-year survivor rate
Maulina Triani, Haris B Widodo, Dody Novrial, Dewi Agustina, Gita Nawangtantrini   +4 more
doaj   +1 more source

Genotoxic and stress inductive potential of cadmium in Xenopus laevis larvae [PDF]

, 2006
The present investigation evaluates the toxic potential of Cd in larvae of the frog Xenopus laevis after 12 days of exposure to environmentally relevant contamination levels, close to those measured in the river Lot (France).
Baudrimont, Magalie, Boudou, Alain, Bourdineaud, Jean-Paul, Cuenot, Y., Gauthier, Laury, Gonzalez, Patrice, Mouchet, Florence   +6 more
core   +3 more sources

Evaluation of the genotoxic and teratogenic potential of a municipal sludge and sludge-amended soil using the amphibian Xenopus laevis and the tobacco: Nicotiana tabacum L. var. xanthi Dulieu [PDF]

, 2003
The toxic, genotoxic and teratogenicpotential of amunicipal sewage sludge was assessed using the micronucleus assay on the larvae of the amphibianXenopuslaevis and with the tobacco somatic mutation test using the yellow–green xanthiDulieu mutant a1+/a1 ...
Chenon, Pascale, Delpoux, Marcel, Gauthier, Laury, Loubières, Pascale, Séverac, Alain   +4 more
core   +4 more sources

Scientific Opinion on the safety evaluation of the substance, 1,3-bis(isocyanatomethyl)benzene, CAS No. 3634-83-1 for use in food contact materials [PDF]

EFSA Journal, 2012
<p>This scientific opinion of EFSA deals with the risk assessment of the monomer 1,3-bis(isocyanatomethyl) benzene, CAS No. 3634-83-1, FCM Substance No 988.
EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF)
doaj   +1 more source