Results 11 to 20 of about 15,524 (254)

Oral Acute Toxicity and Genotoxicity of Heteroctenus junceus Scorpion Venom. [PDF]

Vet Med Sci
The Heteroctenus junceus scorpion venom is a very popular natural extract used in traditional medicine in Cuba. In clinically relevant experimental settings, scorpion venom does not induce general toxicity or an increase in the frequency of micronucleus formation in erythrocytes.
Díaz-García A, Ruiz-Fuentes JL, Mejias Medina S, Zapata Guajardo N, Ross Skarneo C.   +4 more
europepmc   +2 more sources

Cytotoxic, Genotoxic, and Mutagenic Effects of Organotellurane RF07 in Female Swiss Mice (Mus musculus). [PDF]

Chem Biodivers
ABSTRACT The organotellurane RF07 (RF07) is an organic compound containing tellurium, a rare semi‐metal, and its leishmanicidal and antimalarial activity has already been reported in previous studies. This study evaluated the toxic effects of RF07 at 0.42, 21.37, and 42.75 mg/kg using comet assay, micronucleus test, and hematological/biochemical tests ...
de Jesus FEA, Maia OAC, de Lima RMT, de Meneses APM, Moura AS, Campinho Dos Reis A, Barreto do Nascimento MLL, Nobre TA, de Sousa AA, Coelho SGC, Marciel GLDS, Nolêto IRSG, Nunes AMV, Cunha RLOR, de Almeida PM, Felipe Ávila Alcantara DD, de Castro E Sousa JM.   +16 more
europepmc   +2 more sources

Safety assessment of the substance (2E,2'E)-2,4,8,10-tetraoxaspiro[5.5]undecane-3,9-diylbis(2-methylpropane-2,1-diyl) bis(2-cyano-3-(3,4-dimethoxyphenyl)acrylate for use in plastic food contact materials. [PDF]

EFSA J
Abstract The EFSA Panel on Food Contact Materials (FCM) assessed the safety of (2E,2′E)‐2,4,8,10‐tetraoxaspiro[5.5]undecane‐3,9‐diylbis(2‐methylpropane‐2,1‐diyl) bis(2‐cyano‐3‐(3,4‐dimethoxyphenyl)acrylate, which is intended to be used as an additive at up to 0.75% w/w in polyethylene terephthalate (PET) single‐use articles for contact with all types ...
EFSA Panel on Food Contact Materials (FCM), Lambré C, Crebelli R, da Silva M, Grob K, Lampi E, Milana MR, Pronk M, Ščetar M, Theodoridis G, Van Hoeck E, Waegeneers N, Cariou R, Castle L, Di Consiglio E, Franz R, Barthélémy E, Comandella D, Rivière G.   +18 more
europepmc   +2 more sources

Safety assessment of poly(2-ethyl-2-oxazoline) for use in food contact materials. [PDF]

EFSA J
Abstract The EFSA Panel on Food Contact Materials (FCM) assessed the safety of poly(2‐ethyl‐2‐oxazoline) intended to be used as an additive to manufacture repeated use filter membranes based on ■■■■■. The filter membranes are used to process aqueous and alcoholic foods, for up to 24 h per day up to ■■■■■ at temperatures up to 35°C.
EFSA Panel on Food Contact Materials (FCM), Lambré C, Crebelli R, da Silva MJ, Grob K, Lampi E, Milana MR, Pronk M, Ščetar M, Theodoridis G, Van Hoeck E, Waegeneers N, Cariou R, Castle L, Di Consiglio E, Franz R, Barthélémy E, Comandella D, Rivière G.   +18 more
europepmc   +2 more sources

Biomonitoring of the genotoxic potential of aqueous extracts of soils and bottom ash resulting from municipal solid waste incineration, using the comet and micronucleus tests on amphibian (Xenopus laevis) larvae and bacterial assays (MutatoxR and Ames tests) [PDF]

, 2006
The management of contaminated soils and wastes is a matter of considerable human concern. The present study evaluates the genotoxic potential of aqueous extracts of two soils (leachates) and of bottom ash resulting from municipal solid waste ...
Devaux, Alain, Ferrier, Vincent, Gauthier, Laury, Jourdain, Marie-José, Mailhes, Corinne, Mouchet, Florence, Triffault, Gaëlle   +6 more
core   +2 more sources

Giemsa versus acridine orange staining in the fish micronucleus assay and validation for use in water quality monitoring [PDF]

, 2011
This study concerns a comparative analysis of the acridineorange and Giemsastaining procedures for the fish erythrocyte micronucleusassay. The goal was to optimize the assay in the context of field watermonitoring. Fish (Carassius carassius) were exposed
Gauthier, Laury, Jean, Séverine, Laplanche, Christophe, Merlina, Georges, Pinelli, Eric, Polard, Thierry   +5 more
core   +2 more sources

Salivary ki-67 and micronucleus assay as potential biomarker of OSCC in betel nut chewers

Journal of Indian Academy of Oral Medicine and Radiology, 2021
Introduction: Oral cancer is often associated with various factors, such as betel nut consumption, which usually causes specific premalignant lesions. The most common oral cancer is oral squamous cell carcinoma (OSCC) which has a low 5-year survivor rate
Maulina Triani, Haris B Widodo, Dody Novrial, Dewi Agustina, Gita Nawangtantrini   +4 more
doaj   +1 more source

Genotoxic and stress inductive potential of cadmium in Xenopus laevis larvae [PDF]

, 2006
The present investigation evaluates the toxic potential of Cd in larvae of the frog Xenopus laevis after 12 days of exposure to environmentally relevant contamination levels, close to those measured in the river Lot (France).
Baudrimont, Magalie, Boudou, Alain, Bourdineaud, Jean-Paul, Cuenot, Y., Gauthier, Laury, Gonzalez, Patrice, Mouchet, Florence   +6 more
core   +3 more sources

Evaluation of the genotoxic and teratogenic potential of a municipal sludge and sludge-amended soil using the amphibian Xenopus laevis and the tobacco: Nicotiana tabacum L. var. xanthi Dulieu [PDF]

, 2003
The toxic, genotoxic and teratogenicpotential of amunicipal sewage sludge was assessed using the micronucleus assay on the larvae of the amphibianXenopuslaevis and with the tobacco somatic mutation test using the yellow–green xanthiDulieu mutant a1+/a1 ...
Chenon, Pascale, Delpoux, Marcel, Gauthier, Laury, Loubières, Pascale, Séverac, Alain   +4 more
core   +4 more sources

Scientific Opinion on the safety evaluation of the substance, 1,3-bis(isocyanatomethyl)benzene, CAS No. 3634-83-1 for use in food contact materials [PDF]

EFSA Journal, 2012
<p>This scientific opinion of EFSA deals with the risk assessment of the monomer 1,3-bis(isocyanatomethyl) benzene, CAS No. 3634-83-1, FCM Substance No 988.
EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF)
doaj   +1 more source