Results 31 to 40 of about 7,950 (195)

Genotoxicity evaluation of So-ochim-tang-gamibang (SOCG), a herbal medicine

BMC Complementary and Alternative Medicine, 2018
Background So-ochim-tang-gamibang (SOCG) is a traditional Korean medicine frequently used for depression in the clinical field. In this study, we evaluated the potential genotoxicity of SOCG using three standard batteries of tests as part of a safety ...
Mi Young Lee, Yang-Chun Park, Mirim Jin, Eunseok Kim, Jeong June Choi, In Chul Jung   +5 more
doaj   +1 more source

Genotoxicity of Silver Nanoparticles

Nanomaterials, 2020
Silver nanoparticles (AgNPs) are widely used in diverse sectors such as medicine, food, cosmetics, household items, textiles and electronics. Given the extent of human exposure to AgNPs, information about the toxicological effects of such products is ...
Adriana Rodriguez-Garraus, Amaya Azqueta, Ariane Vettorazzi, Adela López de Cerain   +3 more
doaj   +1 more source

Lack of genotoxicity of rhubarb (rhizome) in the Ames and micronucleus in vitro tests

Toxicology Reports, 2022
Hydroxyanthracene derivatives are widely distributed in the plant kingdom, mainly in botanicals such as the Hypericum, Rheum, Rhamnus and Aloe genera.
Gloria Melzi, Corrado L. Galli, Paola Ciliutti, Cristina Marabottini, Marina Marinovich   +4 more
doaj   +1 more source

Antimutagenic effect of resveratrol

Czech Journal of Food Sciences, 2005
Evidence exists from population-based and laboratory studies that some phytochemicals have protective effects against tumors or other diseases and reveal antimutagenic activity.
Martina Langová, Zdeňka Polívková, Petr Šmerák, Jiřina Bártová, Ivo Bárta   +4 more
doaj   +1 more source

Cell phone radiation effects on cytogenetic abnormalities of oral mucosal cells

Brazilian Oral Research, 2015
The aim of this study was to evaluate the effects of exposure to cell phone electromagnetic radiation on the frequency of micronuclei, broken eggs cells, binucleated cells, and karyorrhexis in epithelial cells of the oral mucosa.
Natália Batista DAROIT, Fernanda VISIOLI, Alessandra Selinger MAGNUSSON, Geila Radunz VIEIRA, Pantelis Varvaki RADOS   +4 more
doaj   +1 more source

Genotoxicity evaluation of sodium dehydroacetate

Zhongguo shipin weisheng zazhi, 2020
Objective To study the genotoxicity of sodium dehydroacetate (Na-DHA). Methods Five strains of Salmonella Typhimurium (TA97a, TA98, TA100, TA102 and TA1535) were used with the presence and absence of S9 in bacterial reverse mutation test.
Xue GENG, Xiaopeng ZHANG, Yongning LI, Qiannan ZHANG, Haibo LIU, Wenming CUI, Hui YANG, Zhou YU, Xudong JIA   +8 more
doaj   +1 more source

Study on the genetic damage caused by cadmium sulfide quantum dots in human lymphocytes

Open Life Sciences, 2022
Cadmium sulfide quantum dots (CdS QDs) are being developed for sensors, fluorescent probes, and other platforms and are attracting increasing attention.
Liu Haiping, Liu Huajie, Liu Haiyan, Zhang Duo, Wang Qian, Li Shuang, Cao Yanhua, Li Qingzhao   +7 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Genotoxicity Comparison between Morinda citrifolia Fruit and Seed Substances

Foods, 2022
This study aimed to evaluate the genotoxic potential of the fruit and seed powder, fruit puree, and aqueous extracts of Morinda citrifolia (Rubiaceae, noni).
Sarah Shin, Ji Soo Kim, Myung Ku Park, Ok-Sun Bang   +3 more
doaj   +1 more source

Ribonucleotides Amplify Mitochondrial DNA‐Driven cGAS–STING Activation via FdUMP‐ribonucleotide Hybrid Particles to Potentiate Chemoimmunotherapy

Advanced Science, EarlyView.
This work develops a metabolic sharing strategy that employs cytidine monophosphate (CMP) to competitively reprogram floxuridine (FUDR) pyrimidine metabolism in colorectal tumor cells. Elevated intracellular FdUMP induces nucleotide imbalance, drives mitochondrial DNA release and cGAS‐STING innate immune cascade activation, and potentiates robust ...
Chao Wang, Chenxuan Zhao, Yesong Yao, Zhiwen Zou, Anxin Shi, Zhuo Feng, Mingkang Yang, Yue Yu, Yang Liu, Xuehui Rui, Jinhui Wu   +10 more
wiley   +1 more source