Microphthalmia-Associated Transcription Factor (MITF) Regulates Immune Cell Migration into Melanoma [PDF]
Translational Oncology, 2019 Microphthalmia-associated transcription factor (MITF) is a key transcription factor in melanoma development and progression. MITF amplification and downregulation have been observed in a significant proportion of melanoma patients and correlate with ...
Gabriela M Wiedemann +10 more
doaj +6 more sources
Mutation of microphthalmia-associated transcription factor (mitf) in zebrafish sensitizes for glomerulopathy [PDF]
Biology Open, 2019 Different glomerular diseases that affect podocyte homeostasis can clinically present as nephrotic syndrome with massive proteinuria, hypoalbuminemia, hyperlipidemia and edema.
Janina Müller-Deile +9 more
doaj +6 more sources
Microphthalmia-Associated Transcription Factor: A Differentiation Marker in Uveal Melanoma. [PDF]
Int J Mol Sci, 2023 Microphthalmia-associated transcription factor (MITF) is an important regulator of melanogenesis and melanocyte development. In cutaneous melanoma, MITF loss has been linked to an increased expression of stem cell markers, a shift in epithelial-to ...
Gelmi MC +7 more
europepmc +5 more sources
The underestimated role of the microphthalmia-associated transcription factor (MiTF) in normal and pathological haematopoiesis [PDF]
Cell & Bioscience, 2021 Haematopoiesis, the process by which a restrained population of stem cells terminally differentiates into specific types of blood cells, depends on the tightly regulated temporospatial activity of several transcription factors (TFs).
Alessia Oppezzo, Filippo Rosselli
doaj +3 more sources
Antioxidant Graphene Oxide Nanoribbon as a Novel Whitening Agent Inhibits Microphthalmia-Associated Transcription Factor-Related Melanogenesis Mechanism [PDF]
ACS Omega, 2020 In the melanin synthesis process, oxidative reactions play an essential role, and it is a good strategy to inhibit melanin production by reducing oxidative stress.
Hsin-Yu Chou +6 more
doaj +3 more sources
Microphthalmia-associated transcription factor suppresses invasion by reducing intracellular GTP pools. [PDF]
Oncogene, 2017 Melanoma progression is associated with increased invasion and, often, decreased levels of microphthalmia-associated transcription factor (MITF). Accordingly, downregulation of MITF induces invasion in melanoma cells; however, little is known about the ...
Bianchi-Smiraglia A +17 more
europepmc +5 more sources
Negative Regulatory Loop between Microphthalmia-Associated Transcription Factor (MITF) and Notch Signaling. [PDF]
Int J Mol Sci, 2019 Melanoma, a melanocyte-origin neoplasm, is a highly metastatic and treatment-resistance cancer. While it is well established that notch signaling activation promotes melanoma progression, little is known about the reciprocal interactions between Notch ...
Golan T, Levy C.
europepmc +5 more sources
Microphthalmia-associated transcription factor in melanoma development and MAP-kinase pathway targeted therapy. [PDF]
Pigment Cell Melanoma Res, 2015 Malignant melanoma is a neoplasm of melanocytes, and the microphthalmia‐associated transcription factor (MITF) is essential for the existence of melanocytes.
Wellbrock C, Arozarena I.
europepmc +4 more sources
Mouse microphthalmia-associated transcription factor (Mitf) mutations affect the structure of the retinal vasculature. [PDF]
Acta Ophthalmol, 2022 Mice carrying pathogenic variants in the microphthalmia transcription factor (Mitf) gene show structural and functional changes in the retina and retinal pigment epithelium.
Daníelsson SB +3 more
europepmc +2 more sources
SH3BP2 Silencing Increases miRNAs Targeting ETV1 and Microphthalmia-Associated Transcription Factor, Decreasing the Proliferation of Gastrointestinal Stromal Tumors. [PDF]
Cancers (Basel), 2022 Simple Summary A previous study showed that silencing the adaptor molecule SH3 Binding Protein 2 (SH3BP2) reduced oncogenic KIT and PDGFRA receptor levels and impaired gastrointestinal stromal tumor (GIST) growth.
Proaño-Pérez E +5 more
europepmc +2 more sources