Results 91 to 100 of about 195,958 (227)

The role of Rho GTPases in facial morphogenesis

Developmental Dynamics, EarlyView.
The role of small GTPases, RHOA, RAC1, and CDC42 and pathway mediators is reviewed in the context of embryonic facial development. Lip fusion requires cytoskeletal remodeling during morphogenesis of the facial processes and during lip fusion. Fnm, frontonasal mass; lnp, lateral nasal process; mnp, medial nasal process; mxp, maxillary process; np, nasal
Isra Ibrahim, Joy M. Richman
wiley   +1 more source

MITF and PAX3 play distinct roles in melanoma cell migration; outline of a genetic switch theory involving MITF and PAX3 in proliferative and invasive phenotypes of melanoma

Frontiers in Oncology, 2013
Melanoma is a very aggressive neoplasm with a propensity to undergo progression and invasion early in its evolution. The molecular pathways underpinning invasion in melanoma are now just beginning to be elucidated, but a clear understanding of the ...
Michael R Eccles, Shujie eHe, Antonio eAhn, Lynn eSlobbe, Aaron R Jeffs, Han-Seung eYoon, Bruce C Baguley   +6 more
doaj   +1 more source

Sox11 is required to maintain proper levels of Hedgehog signaling during vertebrate ocular morphogenesis. [PDF]

PLoS Genetics, 2014
Ocular coloboma is a sight-threatening malformation caused by failure of the choroid fissure to close during morphogenesis of the eye, and is frequently associated with additional anomalies, including microphthalmia and cataracts.
Lakshmi Pillai-Kastoori, Wen Wen, Stephen G Wilson, Erin Strachan, Adriana Lo-Castro, Marco Fichera, Sebastiano A Musumeci, Ordan J Lehmann, Ann C Morris   +8 more
doaj   +1 more source

Mitophagy in skeletal muscle: Impact of ageing, exercise and disuse

Experimental Physiology, EarlyView.
Abstract Skeletal muscle plays an important role in whole‐body health, quality of life and regulation of metabolism. The maintenance of a healthy mitochondrial pool is imperative for the preservation of skeletal muscle quality and is mediated through mitochondrial quality control consisting of mitochondrial turnover mediated by a balance between ...
Anastasiya Kuznyetsova, David A. Hood
wiley   +1 more source

Palmitoylethanolamide inhibits rMCP-5 expression by regulating MITF activation in rat chronic granulomatous inflammation [PDF]

, 2014
Chronic inflammation, a condition frequently associated with several pathologies, is characterized by angiogenic and fibrogenic responses that may account for the development of granulomatous tissue.
Aloe, Ambrosino, Annapina Russo, Badertscher, Calignano, Cantarella, D'Agostino, D'Agostino, Daniela De Stefano, Daniele De Filippis, Davide Esposito, De Filippis, De Filippis, De Filippis, De Novellis, Forsberg, Ge, Gianluca Grassia, Giulia Russo, Hamtiaux, He, Hershey, Kitamura, Koludrovic, Lambert, Lo Verme, Mariateresa Cipriano, Morii, Morii, Price, Razin, Rosa Carnuccio, Russo, Russo, Russo, Russo, Sanker, Scuderi, Skaper, Sonnenblick, Strbian, Takeda, Terakawa, Teresa Iuvone, Tomimori, Wong   +45 more
core   +1 more source

Glial cytokine modulation improves sleep and circadian disruption in female SAA knock‐in mice of Alzheimer's‐related pathology

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION Sleep and circadian disturbances are early Alzheimer's disease (AD) features, yet mechanisms linking amyloid pathology, neuroinflammation, and sex differences remain unclear. METHODS We longitudinally assessed sleep, circadian rhythms, and cognition in female and male hAPPSAA knock‐in and control mice from 2 to 19 months using ...
Teresa Macheda, Margaret R. Hawkins, Carrie E. Johnson, Madison G. Lapid, Haleigh R. Whitlock, Savannah M. Shepard, MaKayla F. Cox, Kelly N. Roberts, Leke Bytyqi, Heather M. Hash, Omar A Abou El‐Ezz, Mohammed Abou El‐Ezz, Katherina Kohler, Sridhar Sunderam, Bruce F. O'Hara, Linda J. Van Eldik, Michael P. Murphy, Marilyn J. Duncan, Adam D. Bachstetter   +18 more
wiley   +1 more source

Comparison amount of microphthalmia-associated transcription factor in vitiligo before and after narrowband-ultraviolet B therapy

Dermatology Reports, 2019
Vitiligo is the most commonly seen depigmentation disease with clinical manifestations of milk colored white macules, complex pathogenesis that is not well understood so that evolution of the disease is unpredictable and therapeutic outcomes are often ...
M. Yulianto Listiawan, Linda Astari, Putri Hendria Wardhani   +2 more
doaj   +1 more source

Establishment of an iPSC line (CSUXHi003-A) from a patient with Waardenburg syndrome type Ⅱ caused by a MITF mutation

Stem Cell Research, 2021
Waardenburg syndrome (WS) is a genetic disorder characterized by sensorineural deafness. It has a variable presentation of pigmentation defects. Here, we generated an induced pluripotent stem cell (iPSC) line using episomal plasmid vectors from the ...
Jie Wen, Jian Song, Chufeng He, Jie Ling, Yalan Liu, Hongsheng Chen, Wei Gong, Lingyun Mei, Yong Feng   +8 more
doaj   +1 more source

The Homeobox Genes: Classification, Regulation, Biological Functions, and Diseases

MedComm, Volume 7, Issue 4, April 2026.
Overview of the homeobox gene superfamily and its pathophysiological roles. The homeobox superfamily comprises several major classes, including ANTP, PRD, TALE, LIM, POU, and others. Among these, the HOX clusters (A–D) play critical roles in embryonic development specifically in conferring cellular identity, regulating morphogenesis, and guiding axial ...
Maedeh Dadzadi, Shahin Ramazi, Mona Darvazi, Sepideh Yoosefi, Melika Abbasi, Shirin Farsad   +5 more
wiley   +1 more source

Loss of MITF expression during human embryonic stem cell differentiation disrupts retinal pigment epithelium development and optic vesicle cell proliferation [PDF]

, 2017
Microphthalmia-associated transcription factor (MITF) is a master regulator of pigmented cell survival and differentiation with direct transcriptional links to cell cycle, apoptosis and pigmentation.
Capowski, Elizabeth E., Clark, Eric M., Gamm, David M., Howden, Sara E., Meyer, Jason S., Petelinsek, Anna M., Phillips, M. Joseph, Pinilla, Isabel, Schneider, Bernard L., Simonett, Joseph M., Thomson, James A., Wallace, Kyle A., Wright, Lynda S.   +12 more
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