Results 101 to 110 of about 195,958 (227)
Von Hippel-Lindau protein in the RPE is essential for normal ocular growth and vascular development [PDF]
, 2012 Molecular oxygen is essential for the development, growth and survival of multicellular organisms. Hypoxic microenvironments and oxygen gradients are generated physiologically during embryogenesis and organogenesis.
Abrahams, S. +13 more
core +1 more source
Journal of Extracellular Biology, Volume 5, Issue 3, March 2026.ABSTRACT Extracellular vesicles (EVs) are nanoscale membrane‐bound vesicles released by any cell type under both physiological and pathological conditions. They carry a wide array of bioactive molecules, including microRNAs (miRNAs), lipids, proteins and other small biomolecules, and therefore play a key role in intercellular communication by ...
Tamer Esmail +20 more
wiley +1 more source
Evaluation of antioxidant and anti-melanogenic activities of different extracts from aerial parts of Nepeta binaludensis Jamzad in murine melanoma B16F10 cells [PDF]
Iranian Journal of Basic Medical Sciences, 2016 Objective(s): Nepeta binaludensis Jamzad (Lamiaceae) has been used in folk medicine of Iran to cure various diseases. The plant is an endemic species to the country that has recently been identified in Razavi Khorasan province.
Zahra Tayarani-Najaran +3 more
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Taspase1-dependent TFIIA cleavage coordinates head morphogenesis by limiting Cdkn2a locus transcription [PDF]
, 2015 Head morphogenesis requires complex signal relays to enable precisely coordinated proliferation, migration, and patterning. Here, we demonstrate that, during mouse head formation, taspase1-mediated (TASP1-mediated) cleavage of the general transcription ...
Acampora +17 more
core +2 more sources
Deep Dermal and Subcutaneous Deposits in Thin Melanoma: A Cautionary Tale
Journal of Cutaneous Pathology, Volume 53, Issue 3, Page 224-229, March 2026.ABSTRACT Melanoma microsatellites are peritumoral metastatic deposits and surrogates for potentially aggressive biological behavior. Their presence indicates clinical stage III disease. They are rarely reported in association with thin primary tumors (< 1.0 mm, pT1).
Angela Cheng +5 more
wiley +1 more source
DNA promoter hypermethylation of melanocyte lineage genes determines melanoma phenotype
JCI Insight, 2022 Cellular stress contributes to the capacity of melanoma cells to undergo phenotype switching into highly migratory and drug-tolerant dedifferentiated states.
Adriana Sanna +19 more
doaj +1 more source
Cells, 2022 In recent years, growing evidence has indicated the pivotal role of mitochondria in mast cell immunological activation. We have previously reported a decrease in degranulation and cytokine secretion following the inhibition of pyruvate dehydrogenase (PDH)
Lakshmi Bhargavi Paruchuru +2 more
doaj +1 more source
Control of lysosomal biogenesis and Notch-dependent tissue patterning by components of the TFEB-V-ATPase axis in Drosophila melanogaster [PDF]
, 2016 In vertebrates, TFEB (transcription factor EB) and MITF (microphthalmia-associated transcription factor) family of basic Helix-Loop-Helix (bHLH) transcription factors regulates both lysosomal function and organ development.
Busi, Ilaria +5 more
core +3 more sources
Journal of Cosmetic Dermatology, Volume 25, Issue 3, March 2026.ABSTRACT Background Most pharmacological depigmenting agents and cosmetic skin‐brightening products achieve their effects by suppressing melanogenesis. However, the fate of melanin after melanosome transfer to keratinocytes—and the mechanisms governing its intracellular clearance—remains insufficiently explored.
Xinyi Zhao +3 more
wiley +1 more source
Acta Medica Academica, 2010 Microphthalmia-associated transcription factor (MITF) was first discovered as protein coded by gene whose mutations are associated with Waardenburg syndrome. Later, MITF was shown to be key transcription factor regulating melanogenesis.
Ivan Šamija +2 more
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