Antimelanogenic effect of ginsenoside Rg3 through extracellular signal-regulated kinase-mediated inhibition of microphthalmia-associated transcription factor [PDF]
Journal of Ginseng Research, 2015 Background: Panax ginseng has been used to prolong longevity and is believed to be useful for improving skin complexion. Ginsenosides are the most active components isolated from ginseng, and ginsenoside Rg3 (G-Rg3) in particular has been demonstrated to
Seung Jae Lee +3 more
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microRNA-155, induced by interleukin-1ß, represses the expression of microphthalmia-associated transcription factor (MITF-M) in melanoma cells. [PDF]
PLoS ONE, 2015 Loss of expression of surface antigens represents a significant problem for cancer immunotherapy. Microphthalmia-associated transcription factor (MITF-M) regulates melanocyte fate by driving expression of many differentiation genes, whose protein ...
Nathalie Arts +6 more
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Clinical and Molecular Characterization of Microphthalmia-associated Transcription Factor (MITF)-related Renal Cell Carcinoma. [PDF]
Urology, 2021 OBJECTIVES To characterize the clinical presentation, genomic alterations, pathologic phenotype and clinical management of microphthalmia-associated transcription factor (MITF) familial renal cell carcinoma (RCC), caused by a member of the TFE3, TFEB and
Lang M +6 more
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Microphthalmia-Associated Transcription Factor in Senescence and Age-Related Diseases [PDF]
Gerontology, 2021 Although microphthalmia-associated transcription factor (MITF) has been known for decades as a key regulator for melanocytic differentiation, recent studies expanded its other roles in multiple biological processes.
Jian Zhang +4 more
semanticscholar +3 more sources
The Microphthalmia-Associated Transcription Factor (MITF) and Its Role in the Structure and Function of the Eye. [PDF]
Genes (Basel)Background/Objectives: The microphthalmia-associated transcription factor (Mitf) has been found to play an important role in eye development, structure, and function.
García-Llorca A, Eysteinsson T.
europepmc +2 more sources
Substance P Administered after Myocardial Infarction Upregulates Microphthalmia-Associated Transcription Factor, GATA4, and the Expansion of c-Kit+ Cells. [PDF]
Stem Cells Int, 2020 Microphthalmia-associated transcription factor (MITF), a basic helix-loop-helix leucine zipper transcription factor, can govern gene expression by binding to E box elements in the promoter region of its target gene. Although high levels of MITF have been
Jeong YM, Cheng XW, Kim W.
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MicroRNA-141-3p and microRNA-200a-3p regulate α-melanocyte stimulating hormone-stimulated melanogenesis by directly targeting microphthalmia-associated transcription factor. [PDF]
Sci Rep, 2020 In recent years, it has been reported that non-coding RNAs, especially microRNAs (miRNAs) and long non-coding RNAs, act as melanogenesis-regulating molecules in melanocytes. We found that the expression levels of miR-141-3p and miR-200a-3p were decreased
Itoh T +3 more
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The microphthalmia-associated transcription factor (Mitf) gene and its role in regulating eye function. [PDF]
Sci Rep, 2019 Mutations in the microphthalmia-associated transcription factor (Mitf) gene can cause retinal pigment epithelium (RPE) and retinal dysfunction and degeneration.
García-Llorca A +4 more
europepmc +2 more sources
Novel role of microphthalmia-associated transcription factor in modulating the differentiation and immunosuppressive functions of myeloid-derived suppressor cells [PDF]
Journal for ImmunoTherapy of Cancer, 2023 Background Microphthalmia-associated transcription factor (MITF) is a master regulator of melanogenesis and is mainly expressed in melanoma cells. MITF has also been reported to be expressed in non-pigmented cells, such as osteoclasts, mast cells, and B ...
Yoon Kyung Jeon +8 more
doaj +2 more sources
Inhibition of NAT10 Suppresses Melanogenesis and Melanoma Growth by Attenuating Microphthalmia-Associated Transcription Factor (MITF) Expression. [PDF]
Int J Mol Sci, 2017 N-acetyltransferase 10 (NAT10) has been considered a target for the treatment of human diseases such as cancer and laminopathies; however, its functional role in the biology of melanocytes is questionable.
Oh TI, Lee YM, Lim BO, Lim JH.
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