Preclinical study of microphthalmia-associated transcription factor inhibitor ML329 in gastrointestinal stromal tumor growth [PDF]
Molecular Therapy: OncologyGastrointestinal stromal tumors (GISTs) comprise about 80% of mesenchymal neoplasms in the gastrointestinal tract. Although imatinib mesylate is the preferred treatment, the development of drug resistance highlights the need for novel therapeutic ...
Mario Guerrero +7 more
doaj +2 more sources
Microphthalmia-associated transcription factor up-regulates acetylcholinesterase expression during melanogenesis of murine melanoma cells. [PDF]
J Biol Chem, 2018 Acetylcholinesterase (AChE) hydrolyzes the neurotransmitter acetylcholine in neurons. However, AChE has been proposed to also have nonneuronal functions in different cell types.
Wu Q +9 more
europepmc +2 more sources
Cancer Gene Therapy, 2022 Gastrointestinal stromal tumors (GISTs) are the most common neoplasms of mesenchymal origin, and most of them emerge due to the oncogenic activation of KIT or PDGFRA receptors. Despite their relevance in GIST oncogenesis, critical intermediates mediating the KIT/PDGFRA transforming program remain mostly unknown.
Elizabeth Proaño-Pérez +8 more
semanticscholar +3 more sources
Human disease locus discovery and mapping to molecular pathways through phylogenetic profiling [PDF]
Molecular Systems Biology, 2013 Genes with common profiles of the presence and absence in disparate genomes tend to function in the same pathway. By mapping all human genes into about 1000 clusters of genes with similar patterns of conservation across eukaryotic phylogeny, we ...
Yuval Tabach +9 more
doaj +3 more sources
Aquaculture and Fisheries, 2018 Microphthalmia-associated transcription factor (MITF) is an essential transactivator in melanin synthesis. To characterize the role of MITF in the pearl mussel Hyriopsis cumingii, the MITF homolog of H. cumingii was isolated.
Jiexuan Shen +4 more
doaj +2 more sources
Microphthalmia-associated transcription factor regulates the visual cycle genes Rlbp1 and Rdh5 in the retinal pigment epithelium. [PDF]
Sci Rep, 2016 Regeneration of the visual pigment by cells of the retinal pigment epithelium (RPE) is fundamental to vision. Here we show that the microphthalmia-associated transcription factor, MITF, which plays a central role in the development and function of RPE ...
Wen B +8 more
europepmc +2 more sources
BAF60A mediates interactions between the microphthalmia-associated transcription factor and the BRG1-containing SWI/SNF complex during melanocyte differentiation. [PDF]
J Cell Physiol, 2019 SWI/SNF chromatin remodeling enzymes are multisubunit complexes that contain one of two catalytic subunits, BRG1 or BRM and 9–11 additional subunits called BRG1 or BRM‐associated factors (BAFs).
Aras S +5 more
europepmc +2 more sources
Characterizing the Coding Region Determinant-Binding Protein (CRD-BP)-Microphthalmia-associated Transcription Factor (MITF) mRNA interaction. [PDF]
PLoS ONE, 2017 Coding region determinant-binding protein (CRD-BP) binds to the 3'-UTR of microphthalmia-associated transcription factor (MITF) mRNA to prevent its targeted degradation by miR-340.
Gerrit van Rensburg +2 more
doaj +2 more sources
Fifteen‐year quest for microphthalmia‐associated transcription factor target genes [PDF]
Pigment cell & melanoma research, 2010 Microphthalmia-associated transcription factor (MITF) was initially shown to play a key role in melanocyte differentiation through the direct transcriptional control of TYROSINASE, TYRP1 and DCT genes, encoding the three enzymes involved in melanin synthesis or melanogenesis.
Y. Cheli +3 more
semanticscholar +4 more sources
Melanogenesis-inducing effect of cirsimaritin through increases in microphthalmia-associated transcription factor and tyrosinase expression. [PDF]
Int J Mol Sci, 2015 The melanin-inducing properties of cirsimaritin were investigated in murine B16F10 cells. Cirsimaritin is an active flavone with methoxy groups, which is isolated from the branches of Lithocarpus dealbatus.
Kim HJ +7 more
europepmc +2 more sources