Results 1 to 10 of about 3,879 (89)

microRNA-630 Regulates Underglycosylated IgA1 Production in the Tonsils by Targeting TLR4 in IgA Nephropathy. [PDF]

Front Immunol, 2020
IgA nephropathy (IgAN) is the most common primary glomerular disease. The characteristic pathology involves immune complexes formed by the deposition of IgA1 and underglycosylated IgA1 aggregates in the mesangial area, which may be accompanied by the deposition of IgG and/or IgM and complement components.
Liu C, Ye MY, Yan WZ, Peng XF, He LY, Peng YM.   +5 more
europepmc   +6 more sources

Increased microRNA-630 expression in gastric cancer is associated with poor overall survival. [PDF]

PLoS One, 2014
MicroRNAs are noncoding RNAs that regulate multiple cellular processes during cancer progression. Among various microRNAs, MiR-630 has recently been identified to be implicated in many critical processes in human malignancies. We aimed to investigate the significance and prognostic value of miR-630 in human gastric cancer.
Chu D, Zhao Z, Li Y, Li J, Zheng J, Wang W, Zhao Q, Ji G.   +7 more
europepmc   +6 more sources

MicroRNA 630 Represses NANOG Expression through Transcriptional and Post-Transcriptional Regulation in Human Embryonal Carcinoma Cells. [PDF]

Int J Mol Sci, 2021
The pluripotent transcription factor NANOG is essential for maintaining embryonic stem cells and driving tumorigenesis. We previously showed that PKC activity is involved in the regulation of NANOG expression. To explore the possible involvement of microRNAs in regulating the expression of key pluripotency factors, we performed a genome-wide analysis ...
Chu WK, Hung LM, Hou CW, Chen JK.
europepmc   +4 more sources

Hypoxia-upregulated microRNA-630 targets Dicer, leading to increased tumor progression. [PDF]

Oncogene, 2016
MicroRNAs (miRNAs) are small RNA molecules that affect cellular processes by controlling gene expression. Recent studies have shown that hypoxia downregulates Drosha and Dicer, key enzymes in miRNA biogenesis, causing a decreased pool of miRNAs in cancer and resulting in increased tumor growth and metastasis.
Rupaimoole R, Ivan C, Yang D, Gharpure KM, Wu SY, Pecot CV, Previs RA, Nagaraja AS, Armaiz-Pena GN, McGuire M, Pradeep S, Mangala LS, Rodriguez-Aguayo C, Huang L, Bar-Eli M, Zhang W, Lopez-Berestein G, Calin GA, Calin GA, Sood AK.   +19 more
europepmc   +6 more sources

Circular RNA MTO1 intercorrelates with microRNA-630, both associate with Enneking stage and/or pathological fracture as well as prognosis in osteosarcoma patients. [PDF]

J Clin Lab Anal, 2021
AbstractObjectiveCircular RNA‐mitochondrial tRNA translation optimization 1 (circ‐MTO1) not only involves in bioprocess of various cancers, but also regulates osteosarcoma progression by regulating microRNA‐630 (miR‐630). However, the clinical role of circ‐MTO1 and miR‐630 in osteosarcoma is still obscure.
Shi Z, Wen Y, Zhang S, Cheng X.
europepmc   +4 more sources

MicroRNA-630: A potential guardian against inflammation in diabetic kidney disease. [PDF]

World J Diabetes
In this editorial, we comment on the article by Wu et al published “MicroRNA-630 alleviates inflammatory reactions in rats with diabetic kidney disease by targeting toll-like receptor 4”. Diabetic kidney disease (DKD) stands as a significant complication occurring from diabetes mellitus, which contributes substantially to the morbidity and mortality ...
Al Madhoun A.
europepmc   +3 more sources

MicroRNA-630: A promising avenue for alleviating inflammation in diabetic kidney disease. [PDF]

World J Diabetes
Diabetic kidney disease (DKD) is one of the complications of diabetes, affecting millions of people worldwide. The relentless progression of this condition can lead to kidney failure, requiring life-altering interventions such as dialysis or transplants. Accumulating evidence suggests that immunologic and inflammatory elements play an important role in
Donate-Correa J, González-Luis A, Díaz-Vera J, Hernandez-Fernaud JR.   +3 more
europepmc   +4 more sources

MicroRNA-630 may confer favorable cisplatin-based chemotherapy and clinical outcomes in non-small cell lung cancer by targeting Bcl-2. [PDF]

Oncotarget, 2018
MicroRNA-630 (miR-630) plays dual roles in tumor progression in various human cancers. However, the role of miR-630 in chemoresistance and prognosis in non-small cell lung cancer (NSCLC) remains to be elucidated. This retrospective study enrolled 114 surgically resected patients with NSCLC who experienced tumor relapse and underwent cisplatin-based ...
Chen MJ, Wu DW, Wang GC, Wang YC, Chen CY, Lee H.   +5 more
europepmc   +4 more sources

A low microRNA-630 expression confers resistance to tyrosine kinase inhibitors in EGFR-mutated lung adenocarcinomas via miR-630/YAP1/ERK feedback loop. [PDF]

Theranostics, 2018
Purpose: MicroRNA-630 plays dual roles in apoptosis and drug resistance in human cancers. However, the role of miR-630 in resistance to tyrosine kinase inhibitors (TKIs) in lung adenocarcinoma remains to be elucidated. Methods: Manipulation of miR-630 and its targeted gene YAP1 and/or combination of inhibitor treatments was performed to explore whether
Wu DW, Wang YC, Wang L, Chen CY, Lee H.
europepmc   +3 more sources

MicroRNA-630 suppresses tumor metastasis through the TGF-β- miR-630-Slug signaling pathway and correlates inversely with poor prognosis in hepatocellular carcinoma. [PDF]

Oncotarget, 2016
The epithelial-mesenchymal transition (EMT) is the key process that drives tumor metastasis. Accumulating evidence suggests that the deregulation of some microRNAs (miRNAs), is implicated in this process. Here, we highlight the function and molecular mechanism of miR-630 and its potential clinical application in hepatocellular carcinoma (HCC).
Chen WX, Zhang ZG, Ding ZY, Liang HF, Song J, Tan XL, Wu JJ, Li GZ, Zeng Z, Zhang BX, Chen XP.   +10 more
europepmc   +4 more sources