Results 41 to 50 of about 300,285 (315)

MiRNA-Based Inspired Approach in Diagnosis of Prostate Cancer

Medicina, 2020
Prostate cancer is one of the most encountered cancer diseases in men worldwide and in consequence it requires the improvement of therapeutic strategies. For the clinical diagnosis, the standard approach is represented by solid biopsy.
Vlad Cristian Munteanu, Raluca Andrada Munteanu, Anca Onaciu, Ioana Berindan-Neagoe, Bogdan Petrut, Ioan Coman   +5 more
doaj   +1 more source

Role of exosomal miRNAs in brain metastasis affected by radiotherapy

Translational Neuroscience, 2021
In oncogenesis and development of malignant tumor, microRNAs (miRNAs) regulate the complex gene expression associated with the tumor pathogenesis. Currently, only few studies have been conducted to identify miRNAs and the potential pathways involved in ...
Li Zihuang, Yang Hongli, Ye Ling, Quan Rencui, Chen Meili   +4 more
doaj   +1 more source

microRNAs: Novel regulators of the TGF-β pathway in pancreatic ductal adenocarcinoma

Molecular & Cellular Oncology, 2018
We identified that transforming growth factor-β (TGF-β) induces long non-coding RNA (lncRNA) MIR100HG along with its host microRNAs (miRNAs) miR-100 and miR-125b, to regulate its response in pancreatic ductal adenocarcinoma (PDAC).
Silvia Ottaviani, Leandro Castellano
doaj   +1 more source

Research progress on the regulation of malignant biological behavior of glioma by miRNA-145

Chinese Journal of Contemporary Neurology and Neurosurgery
Glioma is the most malignant brain tumor with high mortality. Due to its complex biological characteristics such as malignant proliferation, invasion, drug resistance, and immunosuppression, the clinical treatment faces great difficulties.
WANG Jun-cheng, LI Xin-long, MA Dong-ming, PAN Ya-wen   +3 more
doaj   +1 more source

Computational Analyses for Identification Novel MicroRNAs from Cattle and Sheep [PDF]

Journal of Cell and Molecular Research, 2012
MicroRNAs (miRNA) are a class of noncoding and regulatory RNA molecules about 22 nucleotides in length. MicroRNAs regulate gene expression by an RNA interfering pathway through cleavage or inhibition of the translation of target mRNA.
Balal Sadeghi, Mohammadreza Nassiri, Ali Masoudi-Nejad, Mojtaba Tahmoorespour, Hesam Dehghani, Hamed Ahmadi   +5 more
doaj   +1 more source

MicroRNA-34, microRNA-130, microRNA-148, microRNA-181, microRNA-194 and microRNA-605 expression in colon cancer tissue

South Russian Journal of Cancer
Purpose of the study. Determination of the expression of microRNA‑34, microRNA‑130, microRNA‑148, microRNA‑181, microRNA‑194 and microRNA‑605 in colon tumor tissue depending on the clinical and morphological features of the tumor and the effectiveness of treatment.Materials and methods.
D. I. Azovsky, S. G. Afanasyev, A. V. Avgustinovich, L. V. Spirina, I. V. Kovaleva, A. B. Zinnurova, V. A. Belova   +6 more
openaire   +2 more sources

Metazoan MicroRNAs [PDF]

Cell, 2018
MicroRNAs (miRNAs) are ∼22 nt RNAs that direct posttranscriptional repression of mRNA targets in diverse eukaryotic lineages. In humans and other mammals, these small RNAs help sculpt the expression of most mRNAs. This article reviews advances in our understanding of the defining features of metazoan miRNAs and their biogenesis, genomics, and evolution.
openaire   +4 more sources

Identifying Potential Biomarkers in Colorectal Cancer and Developing Non-invasive Diagnostic Models Using Bioinformatics Approaches [PDF]

Avicenna Journal of Medical Biochemistry, 2020
Background: Colorectal cancer (CRC) is one of the most frequent causes of gastrointestinal tumors. Due to the invasiveness of the current diagnostic methods, there is an urgent need to develop non-invasive diagnostic approaches for CRC.
Massoud Saidijam, Saeid Afshar, Amir Taherkhani   +2 more
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Expression Levels of miR-30c and miR-186 in Adult Patients with Membranous Glomerulonephritis and Focal Segmental Glomerulosclerosis

International Journal of Nephrology and Renovascular Disease, 2020
Seyyedeh Mina Hejazian,1– 3 Mohammadreza Ardalan,2 Mohammadali M Shoja,4 Nasser Samadi,1 Sepideh Zununi Vahed2 1Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran; 2Kidney ...
Hejazian SM, Ardalan M, Shoja MM, Samadi N, Zununi Vahed S   +4 more
doaj