Results 41 to 50 of about 585,487 (413)
Neurobiology of Disease, 2012 With an estimated life-time prevalence of 15 to 17% and an incapacitating illness in 50% of cases, depressive spectrum disorders represent a heavy public health burden. Despite considerable efforts to underpin the molecular and cellular changes associated with depressive states, a global understanding of the pathophysiology of major depressive ...
Anne Baudry +5 more
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Autoimmunity, 2014 Systemic lupus erythematosus is a prototypic autoimmune disease characterized by the production of an array of pathogenic autoantibodies, including high-affinity anti-dsDNA IgG antibodies, which play an important role in disease development and progression. Lupus preferentially affects women during their reproductive years. The pathogenesis of lupus is
Zan, Hong, Tat, Connie, Casali, Paolo
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Pharmaceutical and Biomedical Research, 2021 Background: There is an intense search for the Coronavirus Disease 19 (COVID-19) cure, to stem the spread and burden of the disease worldwide. Studies revealed that epigenetic modifications impact the pathogenesis of some COVID-19 cases, which can be ...
Tajudeen Yahaya +4 more
doaj
The Effect of Composol Medium on miR-16 Expression during Platelet Storage up to Day 7 at Room Temperature [PDF]
Cell Journal, 2021 Objective: MicroRNAs (miRNAs) are short, noncoding RNAs that play vital roles in gene regulation. It has been shown that storage has an effect on platelet miRNAs.
Ali Rajabi +4 more
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CHO microRNA engineering is growing up : recent successes and future challenges [PDF]
, 2013 microRNAs with their ability to regulate complex pathways that control cellular behavior and phenotype have been proposed as potential targets for cell engineering in the context of optimization of biopharmaceutical production cell lines, specifically of
Barron, Niall +11 more
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Quantitative study of crossregulation, noise and synchronization between microRNA targets in single cells [PDF]
Genome Biology, 2017, 18:37, 2015 Recent studies reported complex post-transcriptional interplay among targets of a common pool of microRNAs, a class of small non-coding downregulators of gene expression. Behaving as microRNA-sponges, distinct RNA species may compete for binding to microRNAs and coregulate each other in a dose-dependent manner.
arxiv +1 more source
Screening for circulating miR-208a and -b in different cardiac arrhythmias of dogs
Journal of Veterinary Research, 2018 In recent years, the high sensitivity and specificity of novel miRNA biomarkers have been utilised for early diagnosis and treatment monitoring of various diseases.
Noszczyk-Nowak Agnieszka +2 more
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Regulation of Cardiac MicroRNAs by Cardiac MicroRNAs [PDF]
Circulation Research, 2013 Rationale: MicroRNAs modestly suppress their direct mRNA targets, and these direct effects are amplified by modulation of gene transcription pathways. Consequently, indirect mRNA modulatory effects of microRNAs to increase or decrease mRNAs greatly outnumber direct target suppressions.
Scot J. Matkovich +2 more
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Alzheimer’s disease: presence and role of microRNAs
Biomolecular Concepts, 2016 Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that accounts for the most cases of dementia. AD affects more than 25 million people globally and is predicted to affect nearly one in 85 people worldwide by 2050.
Basavaraju Manasa +1 more
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Prospective Prediction of Treatment Response in High-Grade Glioma Patients using Pre-Treatment Tumor ADC Value and miR-222 and miR-205 Expression Levels in Plasma [PDF]
Journal of Biomedical Physics and EngineeringBackground: Treatment response in High-grade Glioma (HGG) patients changes based on their genetic and biological characteristics. MiRNAs, as important regulators of drug and radiation resistance, and the Apparent Diffusion Coefficients (ADC) value of ...
Maryam Heidari +6 more
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