Results 211 to 220 of about 50,169 (235)

Microsatellite Instability Testing

2003
Microsatellites are tandem repeats of simple sequences that occur abundantly and are randomly interspersed throughout the human genome. They typically consist of 10-50 copies of 1-6 bp motifs, and are characterized by a high degree of polymorphism. Despite the variability observed among individuals, microsatellite are replicated faithfully at each cell
Y R, Parc, K C, Halling
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Microsatellite instability

Cytogenetic and Genome Research, 2001
Unlike aneuploidy, considered to be the cardinal feature of malignant tumors ever since the chromosomal analysis of neoplastic cells became technically feasible, a second pathway toward malignancy has emerged over the past decade that is not characterized by gross aneuploidy but, instead, by inactivation of the DNA mismatch repair system, leading to a ...
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Microsatellite instability: an update

Archives of Toxicology, 2015
Deficient DNA mismatch repair (MMR) results in a strong mutator phenotype known as microsatellite instability (MSI), which is a hallmark of Lynch syndrome-associated cancers. MSI is characterized by length alterations within simple repeated sequences that are called microsatellites.
Hiroyuki, Yamamoto, Kohzoh, Imai
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Microsatellite instability in esophageal adenocarcinoma

Cancer Letters, 2004
The frequency of microsatellite instability (MSI), a result of defective mismatch repair during DNA replication, has been reported inconsistently in primary esophageal adenocarcinoma (EADC). Using a panel of 15 markers, the primary aim of this study was to analyze the frequency of MSI in a well-characterized series of 27 primary EADCs, defined ...
Susan C, Evans, Amy, Gillis, Laurette, Geldenhuys, Nadine M, Vaninetti, Dickran A, Malatjalian, Geoffrey A, Porter, Duane L, Guernsey, Alan G, Casson   +7 more
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Microsatellite instability in oral cancer

International Journal of Cancer, 1995
AbstractGeneralized genomic instability, detected as somatic changes in allele sizes at microsatellite loci in tumors compared to peripheral lymphocyte DNA, is a recently recognized mechanism of mutation in cancer. Such instability results from the Somatic loss of DNA mismatch repair capability.
C S, Ishwad, R E, Ferrell, K M, Rossie, B N, Appel, J T, Johnson, E N, Myers, J C, Law, S, Srivastava, S M, Gollin   +8 more
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Detection of Microsatellite Instability

2003
In 1993, three groups independently discovered that the lengths of microsatellites in tumors could vary from the normally constant pattern defined at birth (5-5) (see review in ref. 4). This discovery has been designated either microsatellite instability (MSI) or replication errors (RER).
K D, Berg, C A, Griffin, J R, Eshleman
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Microsatellite Instability in Hematological Malignancies

Leukemia & Lymphoma, 2002
The replication error (RER+) phenotype, characterized by microsatellite instability (MSI) has been recently related to mutations of genes involved in DNA mismatch repair pathway. These genetic alterations were first described in hereditary non polyposis colorectal cancer (HNPCC). We examined 44 patients with hematological malignancies (27 AML, 9 MDS, 2
Lenka, Krsková-Honzátková, Jaroslav, Cermák, Jana, Sajdová, Jan, Starý, Petr, Sedlácek, Zuzana, Sieglová   +5 more
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Microsatellite instability in cervical carcinoma

European Journal of Obstetrics & Gynecology and Reproductive Biology, 2001
To investigate the incidence of microsatellite instability (MI) in cervical carcinoma and its relationship with clinicopathological characteristics.A retrospective study of 100 cases of cervical carcinoma.MI, defined as tumor-associated alterations in at least one of five dinucleotide microsatellite markers examined, was detected in 25% of the cervical
T K, Chung, T Y, Ip, G M, Hampton, V W, Wang, T H, Cheung, Y F, Wong   +5 more
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Microsatellite instability in uterine sarcomas

International Journal of Gynecological Cancer, 2001
Studies have shown a 15-30% frequency of microsatellite instability in endometrial cancer. In addition, we found a 21% frequency of microsatellite instability in endometrial cancer. Our aim was to investigate the presence of microsatellite instability and loss of heterozygosity in uterine sarcomas.
Amant, F., Dorfling, C. M., Dreyer, L., Vergote, I., Lindeque, B. G., van Rensburg, E. J.   +5 more
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Microsatellite instability in gallbladder carcinoma

Virchows Archiv, 2015
The genetic abnormalities involved in the pathogenesis of gallbladder carcinoma (GBC) remain unclear. Microsatellite instability (MSI) has been described in many carcinomas, but little is known about the significance of mismatch repair in gallbladder carcinogenesis.
Andrea P, Moy, Mohammad, Shahid, Cristina R, Ferrone, Darrell R, Borger, Andrew X, Zhu, David, Ting, Vikram, Deshpande   +6 more
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