Results 211 to 220 of about 124,795 (370)

Frequent Microsatellite Instability and Mismatch Repair Gene Mutations in Young Chinese Patients With Colorectal Cancer

, 1999
Tzu-Liang Chan, ST Yuen, Leland W.K. Chung, Judy Ho, Kedo Kwan, Annie S.Y. Chan, Jenny Ho, Suet Yi Leung, A H Wyllie   +8 more
openalex   +1 more source

Identification of clinicopathological‐specific driver gene and genetic subtyping of colorectal cancer

Cancer Science, Volume 116, Issue 4, Page 1068-1081, April 2025.
This study analyzed targeted sequencing of 6530 patients with metastatic Chinese colorectal cancer (CRC), identifying 36 novel driver genes with subgroup‐specific implications, such as ERBB4 affecting only male CRC patient outcomes. Additionally, the study utilized network‐based stratification to categorize microsatellite stable (MSS) and unstable (MSI)
Jianjiong Li, Chunnian Wang, Changshun Yang, Hua Bao, Ningyou Li, Xianqiang Huang, Wei Gong, Xinyue Hong, Jiani C. Yin, Jiaohui Pang, Meifu Gan, Danping Yuan   +11 more
wiley   +1 more source

Artificial intelligence-driven microsatellite instability profiling reveals distinctive genetic features in patients with lung cancer. [PDF]

Cancer
Thomas QD, Vendrell JA, Khellaf L, Cavaillon S, Quantin X, Solassol J, Cabello-Aguilar S.   +6 more
europepmc   +1 more source

Clinical usefulness of microsatellite instability for the prediction of gastric adenoma or adenocarcinoma in patients with chronic gastritis [PDF]

, 2000
Kazuhiro Kashiwagi, Mamoru Watanabe, Taisuke Ezaki, Takanori Kanai∥, Hiromasa Ishii, Masaru Mukai, Toshifumi Hibi∥   +6 more
openalex   +1 more source

Mutation Analysis of TMB‐High Colorectal Cancer: Insights Into Molecular Pathways and Clinical Implications

Cancer Science, Volume 116, Issue 4, Page 1082-1093, April 2025.
Colorectal cancer (CRC) tumors with high tumor mutation burden (TMB) often exhibit distinct molecular features, including lower KRAS and higher BRAF mutation frequencies, microsatellite instability (MSI), and a mutational signature linked to the CpG island methylator phenotype (CIMP).
Yuko Chikaishi, Hiroshi Matsuoka, Eiji Sugihara, Mayu Takeda, Makoto Sumitomo, Seiji Yamada, Gaku Inaguma, Yusuke Omura, Yeongcheol Cheong, Yosuke Kobayashi, Masaya Nakauchi, Junichiro Hiro, Koji Masumori, Koki Otsuka, Hiroshi Nishihara, Koichi Suda, Hideyuki Saya, Tetsuya Takimoto   +17 more
wiley   +1 more source

Microsatellite instability-high status as a pan-cancer biomarker for immunotherapy efficacy. [PDF]

Cancer Immunol Immunother
Landre T, Des Guetz G.
europepmc   +1 more source

Microsatellite instability in tumors as a model to study the process of microsatellite mutations [PDF]

, 2000
Rosane Sturzeneker
openalex   +1 more source

Epacadostat Overcomes Cetuximab Resistance in Colorectal Cancer by Targeting IDO‐Mediated Tryptophan Metabolism

Cancer Science, EarlyView.
The effect of cetuximab and epacadostat combinative therapy on CRC cells. ABSTRACT Primary or acquired mutations in RAS/RAF genes resulting in cetuximab resistance have limited its clinical application in colorectal cancer (CRC) patients. The mechanism of this resistance remains unclear.
Yimin Zhou, Qiongyan Tao, Chubin Luo, Jinsong Chen, Genwen Chen, Jianyong Sun   +5 more
wiley   +1 more source

<i>MLH1</i> Methylation Status and Microsatellite Instability in Patients with Colorectal Cancer. [PDF]

Genes (Basel)
Rico-Méndez MA, Trujillo-Rojas MA, Ayala-Madrigal ML, Hernández-Sandoval JA, González-Mercado A, Gutiérrez-Angulo M, Romero-Quintana JG, Valenzuela-Pérez JA, Ramírez-Ramírez R, Flores-López BA, Moreno-Ortiz JM.   +10 more
europepmc   +1 more source

The effect of mismatch repair deficiency on tumourigenesis; microsatellite instability affecting genes containing short repeated sequences. [PDF]

, 2000
J T Johannsdottir, Jón G. Jónasson, Jón Þór Bergþorsson, Laufey T. Ámundadóttir, Jónas Magnússon, Valgarður Egilsson, Sigurður Ingvarsson   +6 more
openalex   +1 more source