Results 1 to 10 of about 59,126 (309)

Obesity, aldosterone excess, and mineralocorticoid receptor activation: Parallel or intersected circumstances? [PDF]

The Journal of Clinical Hypertension
The obesity pandemic, with its associated comorbidities of hypertension and diabetes, constitutes a global public health issue. Importantly, there is an increasing prevalence of aldosterone excess related to obesity and resultant poor health outcomes ...
Houry Puzantian, Raymond Townsend, Shweta Bansal   +2 more
doaj   +3 more sources

Does Mineralocorticoid Receptor Antagonism Prevent Calcineurin Inhibitor-Induced Nephrotoxicity? [PDF]

Frontiers in Medicine, 2017
Calcineurin inhibitors have markedly reduced acute rejection rates in renal transplantation, thus significantly improved short-term outcome. The beneficial effects are, however, tampered by acute and chronic nephrotoxicity leading to interstitial ...
Line Aas Mortensen, Line Aas Mortensen, Claus Bistrup, Claus Bistrup, Helle Charlotte Thiesson, Helle Charlotte Thiesson   +5 more
doaj   +2 more sources

Mineralocorticoid receptor activation contributes to intestinal fibrosis through neutrophil gelatinase-associated lipocalin in preclinical models [PDF]

Nature Communications
Intestinal fibrosis is a common complication in inflammatory bowel diseases with no specific therapy. Because mineralocorticoid receptor antagonism prevented inflammation and fibrosis in extra-intestinal organs, we aimed to evaluate mineralocorticoid ...
Asma Amamou, Mathilde Leboutte, Jonathan Breton, David Ribet, Pierre-Alain Thiebaut, Christine Bôle-Feysot, Charlène Guérin, Kanhia Aublé, Elise Rebollo, Lise Ratel, Benjamin Bonnard, Alexis Goichon, Louison Leblond, Moutaz Aziz, Elodie Fermant, Frédéric Jaisser, Guillaume Savoye, Rachel Marion-Letellier   +17 more
doaj   +2 more sources

Mineralocorticoid Receptor Blocker Prevents Mineralocorticoid Receptor–Mediated Inflammation by Modulating Transcriptional Activity of Mineralocorticoid Receptor–p65–Signal Transducer and Activator of Transcription 3 Complex [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Mineralocorticoid receptor (MR) induces cardiac inflammation cooperatively with nuclear factor‐κB and signal transducer and activator of transcription 3 (STAT3); MR blockers exert anti‐inflammatory effects.
Naoto Kuyama, Satoshi Araki, Koichi Kaikita, Nobuhiro Nakanishi, Naoya Nakashima, Shinsuke Hanatani, Yuichiro Arima, Masahiro Yamamoto, Taishi Nakamura, Eiichiro Yamamoto, Kenichi Matsushita, Kunihiko Matsui, Kenichi Tsujita   +12 more
doaj   +2 more sources

In Silico Investigation of Mineralocorticoid Receptor Antagonists: Insights into Binding Mechanisms and Structural Dynamics [PDF]

Molecules
The mineralocorticoid receptor (MR) is a steroid hormone receptor that plays a key role in regulating sodium and water homeostasis and blood pressure.
Julia J. Liang, Sara Cao, Andrew Hung, Assam El-Osta, Tom C. Karagiannis, Morag J. Young   +5 more
doaj   +2 more sources

Administration of finerenone in chronic kidney disease [PDF]

Journal of Nephropathology, 2023
Spironolactone is a first-generation and non-selective mineralocorticoid receptor antagonist (MRA). It is extensively well-studied and recommended due to increased accessibility for patients.
Mohsen Akhavan Sepahi, Elham Emami, Akshaya Ann Joseph, Shakiba Hassanzadeh, Mohammad Reza Razavi   +4 more
doaj   +1 more source

Vascular cell‐specific roles of mineralocorticoid receptors in pulmonary hypertension

Pulmonary Circulation, 2021
Abnormalities that characterize pulmonary arterial hypertension include impairment in the structure and function of pulmonary vascular endothelial and smooth muscle cells.
Divya P. Menon, Guanming Qi, Seung K. Kim, M. Elizabeth Moss, Krishna C. Penumatsa, Rod R. Warburton, Deniz Toksoz, Jamie Wilson, Nicholas S. Hill, Iris Z. Jaffe, Ioana R. Preston   +10 more
doaj   +1 more source

Beneficial effects of proanthocyanidins in the cardiac alterations induced by aldosterone in rat heart through mineralocorticoid receptor blockade. [PDF]

PLoS ONE, 2014
Aldosterone administration in rats results in several cardiac alterations. Previous studies have demonstrated that proanthocyanidins, phenolic bioactive compounds, have cardioprotective effects.
Beatriz Martín-Fernández, Natalia de las Heras, María Valero-Muñoz, Sandra Ballesteros, Yi-Zhou Yao, Peter G Stanton, Peter J Fuller, Vicente Lahera   +7 more
doaj   +1 more source

Mineralocorticoid receptor antagonists as a potential treatment option in persistent subretinal fluid following the repair of a rhegmatogenous retinal detachment

American Journal of Ophthalmology Case Reports, 2023
Purpose: To report the resolution of subretinal fluid persisting more than a year following retinal detachment surgery resolving with a short term course of mineralocorticoid receptor antagonists use.
Mohamad El Wardani, Marc D. de Smet
doaj   +1 more source

Role of spironolactone in patients with resistant hypertension: A narrative review

Heart India, 2021
Treatment-resistant hypertension (RH) is defined as uncontrolled blood pressure (BP) despite use of at least three different antihypertensive agents (including angiotensin-converting enzyme inhibitor or angiotensin receptor blocker, calcium channel ...
Geeta Sheth, Kavita Joshi
doaj   +1 more source