Results 11 to 20 of about 57,284 (206)

30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Mineralocorticoid receptor mutations [PDF]

Journal of Endocrinology, 2017
Aldosterone and the mineralocorticoid receptor (MR) are key elements for maintaining fluid and electrolyte homeostasis as well as regulation of blood pressure. Loss-of-function mutations of the MR are responsible for renal pseudohypoaldosteronism type 1 (PHA1), a rare disease of mineralocorticoid resistance presenting in the newborn with weight loss ...
Maria-Christina, Zennaro, Fabio, Fernandes-Rosa   +1 more
openaire   +2 more sources

Mineralocorticoid receptor antagonists as a potential treatment option in persistent subretinal fluid following the repair of a rhegmatogenous retinal detachment

American Journal of Ophthalmology Case Reports, 2023
Purpose: To report the resolution of subretinal fluid persisting more than a year following retinal detachment surgery resolving with a short term course of mineralocorticoid receptor antagonists use.
Mohamad El Wardani, Marc D. de Smet
doaj   +1 more source

Mineralocorticoid receptor blockade for renoprotection

Kidney Research and Clinical Practice, 2018
Dae Ryong Cha
doaj   +3 more sources

Role of spironolactone in patients with resistant hypertension: A narrative review

Heart India, 2021
Treatment-resistant hypertension (RH) is defined as uncontrolled blood pressure (BP) despite use of at least three different antihypertensive agents (including angiotensin-converting enzyme inhibitor or angiotensin receptor blocker, calcium channel ...
Geeta Sheth, Kavita Joshi
doaj   +1 more source

Carbonyl reductase 1 amplifies glucocorticoid action in adipose tissue and impairs glucose tolerance in lean mice

Molecular Metabolism, 2021
Objective: Carbonyl reductase 1 (Cbr1), a recently discovered contributor to tissue glucocorticoid metabolism converting corticosterone to 20β-dihydrocorticosterone (20β-DHB), is upregulated in adipose tissue of obese humans and mice and may contribute ...
Rachel M.B. Bell, Elisa Villalobos, Mark Nixon, Allende Miguelez-Crespo, Lee Murphy, Angie Fawkes, Audrey Coutts, Matthew G.F. Sharp, Martha V. Koerner, Emma Allan, Onno C. Meijer, Renè Houtman, Alex Odermatt, Katharina R. Beck, Scott G. Denham, Patricia Lee, Natalie Z.M. Homer, Brian R. Walker, Ruth A. Morgan   +18 more
doaj   +1 more source

Drug treatment of hypertension: focus on vascular health [PDF]

, 2016
Hypertension, the most common preventable risk factor for cardiovascular disease and death, is a growing health burden. Serious cardiovascular complications result from target organ damage including cerebrovascular disease, heart failure, ischaemic heart
Cameron, Alan C., Lang, Ninian N., Touyz, Rhian M.   +2 more
core   +1 more source

New Perspectives on Sex Steroid and Mineralocorticoid Receptor Signaling in Cardiac Ischemic Injury

Frontiers in Physiology, 2022
The global burden of ischemic heart disease is burgeoning for both men and women. Although advances have been made, the need for new sex-specific therapies targeting key differences in cardiovascular disease outcomes in men and women remains ...
Laura A. Bienvenu, Laura A. Bienvenu, James R. Bell, Kate L. Weeks, Kate L. Weeks, Lea M. D. Delbridge, Morag J. Young, Morag J. Young   +7 more
doaj   +1 more source

Nuclear receptors in vascular biology [PDF]

, 2015
Nuclear receptors sense a wide range of steroids and hormones (estrogens, progesterone, androgens, glucocorticoid, and mineralocorticoid), vitamins (A and D), lipid metabolites, carbohydrates, and xenobiotics.
A Chawla, A McCurley, AA Hamers, AL Bookout, B Fisslthaler, BG Hoebel, C McCarthy, C Zhou, CH Lee, CK Glass, CK Huang, CT Lee, D Bishop-Bailey, D Bishop-Bailey, David Bishop-Bailey, DP Edwards, E Gerlach, F Akbiyik, FA Pereira, FL Wynne, FY Ali, G Pascual, I Dussault, I Spoletini, J He, J Qin, J Sonoda, J Xiang, K Spruiell, KE Swales, L Calza, L Li, L Piqueras, LA Moraes, LA Moraes, LJ Jonk, LR You, M Kaushik, M Matic, N Albermann, N Schafer, N Takamoto, Q Qin, R Zhao, S Asgary, S Chakrabarti, S Marino De, S Stein, SA Kliewer, V Zoete, W El-Sankary, WC Lau, X Wang, Y Ma, Y Sui, Y Sui, YW Hu   +56 more
core   +3 more sources

Mineralocorticoid receptor overactivation-induced remodeling of obese adipose tissue [PDF]

Xin yixue
Obesity is a chronic disease caused by the long-term interaction of multiple environmental factors on a specific genetic background. Among these factors， the overactivation of mineralocorticoid receptors （MR） plays a significant role in adipose tissue ...
WEN Runzhi, WANG Li, ZHAO Naiqian
doaj   +1 more source

The effect of eplerenone on adenosine formation in humans in vivo: a double-blinded randomised controlled study. [PDF]

PLoS ONE, 2014
It has been suggested that mineralocorticoid receptor antagonists have direct cardioprotective properties, because these drugs reduce mortality in patients with heart failure.
T N A van den Berg, Jaap Deinum, Albert Bilos, A Rogier T Donders, Gerard A Rongen, Niels P Riksen   +5 more
doaj   +1 more source