Results 101 to 110 of about 15,193 (187)

miR-29a-3p/T-bet Regulatory Circuit Is Altered in T Cells of Patients With Hashimoto’s Thyroiditis

Frontiers in Endocrinology, 2018
ObjectiveHashimoto’s thyroiditis (HT) is a common autoimmune thyroid disorder that frequently evolves from asymptomatic, T-cell mediated chronic inflammation toward overt hypothyroidism. Previously, we have demonstrated a role for T-bet, a T helper 1/CD8+
Stana Tokić, Stana Tokić, Mario Štefanić, Ljubica Glavaš-Obrovac, Amit Kishore, Zdenka Navratilova, Martin Petrek   +6 more
doaj   +1 more source

MicroRNA Profiling Implies New Markers of Gemcitabine Chemoresistance in Mutant p53 Pancreatic Ductal Adenocarcinoma

, 2016
Background: No reliable predictors of susceptibility to gemcitabine chemotherapy exist in pancreatic ductal adenocarcinoma (PDAC). MicroRNAs (miR) are epigenetic gene regulators with tumorsuppressive or oncogenic roles in various carcinomas.
Dhayat, S. (Sameer), Haier, J. (Jörg), Hummel, R. (Richard), Mardin, W.A.M. (Wolf), Matuszcak, C. (Christiane), Mees, S.T. (Sören), Seggewiß, J. (Jochen), Senninger, N. (Norbert), Ströse, A.J. (Anda)   +8 more
core   +1 more source

Application Strategies of Bone Marrow Mesenchymal Stromal Cells in Bone‐Related Diseases

Cell Proliferation, EarlyView.
Engineered BMSCs and vesicles enhance therapy effects for bone diseases via multi‐strategic approaches. ABSTRACT Bone‐related diseases (e.g., osteoporosis, osteoarthritis and fractures) exhibit a rising global incidence, imposing significant burdens on both quality of life and healthcare systems.
Xuemei Long, Dan Tan, Qianke Tao, Qiaonan Ye, Luwen Ye, Qing Li, Jingang Xiao   +6 more
wiley   +1 more source

Downregulation of RGMA by HIF-1A/miR-210-3p axis promotes cell proliferation in oral squamous cell carcinoma

Biomedicine & Pharmacotherapy, 2019
Repulsive guidance molecules comprise a group of proteins that play an important role in carcinogenesis through interactions with their receptors, but their function in oral squamous cell carcinoma (OSCC) is unclear. Here, we investigated the potential role of the RGM family members in oral cancer pathogenesis.
Yingjuan, Lu, Yingru, Li, Zhangsong, Wang, Shule, Xie, Qing, Wang, Xinyuan, Lei, Yi, Ruan, Jinsong, Li   +7 more
openaire   +2 more sources

Structuring osteosarcoma knowledge: an osteosarcoma-gene association database based on literature mining and manual annotation

, 2014
Osteosarcoma (OS) is the most common primary bone cancer exhibiting high genomic instability. This genomic instability affects multiple genes and microRNAs to a varying extent depending on patient and tumor subtype.
Baumhoer, D. (Daniel), Korsching, E.U. (Eberhard), Maugg, D. (Doris), Nathrath, M. (Michaela), Neumann, A. (Anna), Poos, K. (Kathrin), Smida, J. (Jan)   +6 more
core   +1 more source

Cellular Signalling Networks in High Altitude Pulmonary Hypertension: From Canonical Pathways to Emerging Targets

Cell Proliferation, EarlyView.
This review elucidates the intricate cellular signalling networks involved in high‐altitude pulmonary hypertension (HAPH), integrating canonical pathways like HIF, MAPK and BMP with emerging targets such as Wnt/β‐catenin, Notch, Hippo‐YAP and IL‐6. It highlights potential therapeutic strategies targeting these pathways to mitigate vascular remodelling ...
Sheng Ding, Ju Chen, Zhaoyang Li, Yang Yu, Weijie Wang, Yan Liao, Jin Yang, Dianxiang Lu, Yujiang Fan   +8 more
wiley   +1 more source

Longitudinal trajectory of circulating microRNA-210-3p and its association with low-dose aspirin use in gestational hypertension and preeclampsia: a pilot study

Clinical and Experimental Hypertension
Background Circulating microRNA-210-3p (miR-210-3p) is a hypoxia-related regulator implicated in placental maladaptation. Its longitudinal behavior across hypertensive disorders of pregnancy (HDP), and whether low-dose aspirin modifies its trajectory ...
Ming-Ju Wang, Chie-Pein Chen, Nan-Fu Chiu, Fang-Ju Sun, Hsin-Yi Hou, Chen-Yu Chen   +5 more
doaj   +1 more source

Developmental expression of Ap‐Vas proteins in aphids and flies reveals their evolutionary roles in insects

Insect Molecular Biology, EarlyView.
Duplication of vas genes is universally observed in aphids, and phylogenetic analysis indicates that this event predates the divergence of Aphididae and Phylloxeridae. Ap‐vas1 is germline‐specific, whereas Ap‐vas2–4 exhibit somatic expression, indicating functional divergence during aphid embryogenesis.
Gee‐Way Lin, Szu‐Chieh Wang, Charles E. Cook, Ming‐Der Lin, Chun‐che Chang   +4 more
wiley   +1 more source

Discovery and Validation of Circulating Hsa-miR-210-3p as a Potential Biomarker for Primary Open-Angle Glaucoma

Investigative Opthalmology & Visual Science, 2019
Blood-based examination tools for glaucoma diagnosis in clinical practice, which can be useful for screening patients when traditional ophthalmic examinations cannot be utilized, are not available thus far. This study aimed to identify circulating microRNAs (miRNAs) associated with primary open-angle glaucoma (POAG) and explore their utility as ...
Yaoming, Liu, Yayi, Wang, Yang, Chen, Xiuli, Fang, Tao, Wen, Mianli, Xiao, Shida, Chen, Xiulan, Zhang   +7 more
openaire   +2 more sources

Hyperthermia upregulates exosomal miR-210-3p to target GPD1L activating PI3K/AKT pathway and promoting atrial fibrosis

International Journal of Hyperthermia
Objective This study seeks to examine the role of miR-210-3p, delivered by atrial myocyte-derived exosomes, in the progression of atrial fibrosis after hyperthermia.Methods Firstly, by conducting a bioinformatics analysis on the miRDB, miRTarbase, and ...
Huixian Li, Feixing Li, Zhongbao Ruan
doaj   +1 more source