Results 111 to 120 of about 15,720 (202)

Downregulation of RGMA by HIF-1A/miR-210-3p axis promotes cell proliferation in oral squamous cell carcinoma

Biomedicine & Pharmacotherapy, 2019
Repulsive guidance molecules comprise a group of proteins that play an important role in carcinogenesis through interactions with their receptors, but their function in oral squamous cell carcinoma (OSCC) is unclear. Here, we investigated the potential role of the RGM family members in oral cancer pathogenesis.
Yingjuan, Lu, Yingru, Li, Zhangsong, Wang, Shule, Xie, Qing, Wang, Xinyuan, Lei, Yi, Ruan, Jinsong, Li   +7 more
openaire   +2 more sources

Hyperthermia upregulates exosomal miR-210-3p to target GPD1L activating PI3K/AKT pathway and promoting atrial fibrosis

International Journal of Hyperthermia
Objective This study seeks to examine the role of miR-210-3p, delivered by atrial myocyte-derived exosomes, in the progression of atrial fibrosis after hyperthermia.Methods Firstly, by conducting a bioinformatics analysis on the miRDB, miRTarbase, and ...
Huixian Li, Feixing Li, Zhongbao Ruan
doaj   +1 more source

Innate Immune Activation Is a Strong Suppressor of CCL22 and Impedes Regulatory T Cell–Dendritic Cell Interaction

Immunology, EarlyView.
During homeostasis, CCL22 is secreted by dendritic cells (DC), which mediate contacts between regulatory T cells (Treg) and DC to maintain immune balance. Activation of innate immunity via microbes or pattern recognition receptor (PRR) agonists induces the secretion of several soluble factors (e.g., type I and II interferons, IL‐10), which mediate ...
Ignazio Piseddu, Jan Gärtig, Stephan Eiber, Stefan Moder, Raffael Thaler, Matthias Thaler, Juliane Gruen, Marlies Vornhülz, Kevin Bahner, Luana Messa, Benjamin Kühnemuth, Jennifer Müller, Konstantin Schnell, Antonia Beimert, Carolin Perleberg, Natascha Röhrle, Maximilian Martin Ludwig Knott, Linda Hammann, Vanessa Wittmann, Patrick Layritz, Moritz Rapp, Carole Bourquin, Julia Mayerle, Stefan Endres, David Anz   +24 more
wiley   +1 more source

Longitudinal trajectory of circulating microRNA-210-3p and its association with low-dose aspirin use in gestational hypertension and preeclampsia: a pilot study

Clinical and Experimental Hypertension
Background Circulating microRNA-210-3p (miR-210-3p) is a hypoxia-related regulator implicated in placental maladaptation. Its longitudinal behavior across hypertensive disorders of pregnancy (HDP), and whether low-dose aspirin modifies its trajectory ...
Ming-Ju Wang, Chie-Pein Chen, Nan-Fu Chiu, Fang-Ju Sun, Hsin-Yi Hou, Chen-Yu Chen   +5 more
doaj   +1 more source

Changes in nuclear and cytoplasmic microRNA distribution in response to hypoxic stress [PDF]

, 2019
MicroRNAs (miRNAs) are small non-coding RNAs that have well-characterized roles in cytoplasmic gene regulation, where they act by binding to mRNA transcripts and inhibiting their translation (i.e. post-transcriptional gene silencing, PTGS).
Korhonen, P, Laitinen, P, Malm, T, Roberts, Thomas, Turunen, MP, Turunen, TA, Väänänen, M-A, Ylä-Herttuala, S   +7 more
core   +2 more sources

Harnessing the Therapeutic Potential of Cell Secretomes and Extracellular Vesicles for Craniofacial Regenerative Applications

Journal of Periodontal Research, EarlyView.
The scoping review summarizes the current preclinical and clinical evidence for the use of “cell‐free” therapies in craniofacial (periodontal, bone and soft‐tissue) regeneration. It also aims to highlight key challenges and strategies towards the clinical translation of these therapies.
Siddharth Shanbhag, Magdalena Mayol, Danijel Domic, Madhusudhan Reddy Bobbili, Johannes Grillari, Mariano Sanz, Reinhard Gruber   +6 more
wiley   +1 more source

A meta-Analysis revealed insights into the sources, conservation and impact of microRNA 5′-isoforms in four model species [PDF]

, 2013
MicroRNA (miRNA) 5′-isoforms, or 5′-isomiRs, are small-RNA species that originate from the same genomic loci as the major miRNAs with their 5′ ends shifted from the 5′ ends of the miRNAs by a few nucleotides. Although 5′-isomiRs have been reported, their
Xia, Jing, Zhang, Weixiong
core   +2 more sources

Hypoxia and hypercapnia elicit overlapping but distinct skeletal muscle toxicities

The Journal of Physiology, EarlyView.
Abstract figure legend Hypoxia and hypercapnia cause overlapping skeletal muscle phenotypes, including atrophy, change in myofibre metabolic profile and myogenic response to injury. Both signals operate via distinct cellular pathways. Abstract Skeletal muscle dysfunction is strongly associated with elevated mortality in acute and chronic pulmonary ...
Joseph Balnis, Ariel Jaitovich
wiley   +1 more source

Implication of microRNAs as messengers of exercise adaptation in junior female triathlonists

Scientific Reports
While expression profile of muscle-specific miRNAs following endurance training is well-characterized, information about exercise-induced changes of metabolism-regulating miRNAs is limited, especially in female and junior athletes.
Zsuzsanna Gaál, János Fodor, Tamás Oláh, Ivett Gabriella Szabó, Ildikó Balatoni, László Csernoch   +5 more
doaj   +1 more source

kNNPC (k‐Nearest Neighbor Algorithm Per‐Class): Classification Method Predicting Extrapolation Regions With Reasonable Probability

Journal of Chemometrics, Volume 40, Issue 6, June 2026.
ABSTRACT In classification tasks, predicted class probabilities are often overconfident for samples outside the training distribution, which can lead to unsafe decision‐making. kNNPC, a k‐nearest neighbor algorithm per class, is proposed to mitigate such overconfidence under extrapolation or distribution shift.
Hiromasa Kaneko
wiley   +1 more source