Results 131 to 140 of about 367,365 (231)

Cardiovascular Outcomes With SGLT‐2 Inhibitors in Patients With Type 2 Diabetes and Obstructive Sleep Apnoea: A Real‐World Analysis

Diabetes, Obesity and Metabolism, EarlyView.
Reuben L. Odai, Dennis Dela Tsagli, Anthony Alchaer, Laiba Sajjad, Kwame Adjei‐Sefah, Chukwuemeka Aghasili, Smith Frimpong, Hussam Farhoud   +7 more
wiley   +1 more source

Novel Biomaterial‐Based Synovial Fluid Analysis Reveals Protective microRNA Signatures in a Mouse Model of Acute Synovitis‐Driven Osteoarthritis

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
We successfully established a novel method for collecting synovial fluid in the murine knee joint using Tetra‐slime. Acute synovitis led to secondary cartilage degeneration in the early stage of OA, which might be attributed to the increase of MMP‐3, TNF‐α, and M1 macrophage activation in the synovium.
Kei Takahata, Kohei Arakawa, Takashi Yasuda, Saaya Enomoto, Takuya Katashima, Takamasa Sakai, Takanori Kokubun   +6 more
wiley   +1 more source

Auto‐Generated Valence States in Electrocatalysts for Boosting Oxygen and Hydrogen Evolution Kinetics in Alkaline Water/Alkaline Seawater/Simulated Seawater/Natural Seawater

Advanced Functional Materials, Volume 36, Issue 45, 5 June 2026.
This review systematically highlights the latest achievements in mixed‐valence states relevant to hydrogen and oxygen evolution reactions, providing essential insights into future directions and methods for large‐scale practical implementation. This critical review is expected to provide an overview of recent advancements in diverse valence‐state metal
Jitendra N. Tiwari, Gokul Bhaskaran, Krishan Kumar, Yun Suk Huh, Young‐Kyu Han   +4 more
wiley   +1 more source

Small Extracellular Vesicles from Neural Cells: Physiological and Pathological Roles, and Potential in Neurodegenerative Therapy

Advanced Healthcare Materials, Volume 15, Issue 21, 5 June 2026.
Neural cell–derived small extracellular vesicles (sEVs) are emerging as pivotal mediators in neurodegenerative diseases, exerting both pathogenic and therapeutic functions. This review synthesizes current evidence on how sEVs from distinct neural cell types regulate neurodegeneration, neuroprotection, biomarker discovery, and targeted drug delivery ...
Muhammad Waqas Salim, Wei Zhang, Lyndsey Collins‐Praino, Yuling Wang, Andrew Care   +4 more
wiley   +1 more source

The miR-590 C57T SNP reduces levels of miR-590-5p and miR-590-3p, without affecting the levels of pri-miR-590 and pre-miR-590.

, 2016
(A) Quantification of pri-miR-590 by qRT-PCR normalized by GAPDH. Mean ± SD (n = 3). HEK293T cells were transfected with the pri-miR-590-WT or pri-miR-590-SNP plasmids. The empty plasmid was used as negative control.
Suresh K. Kandasamy (2794198), Steven Steinberg (582816), Scot J. Matkovich (421129), Neal Epstein (2794180), Dotti Tripodi (2794204), Garry Cutting (2794201), Xiaoping Lin (215407), Blaid Mbiyangandu (2794195), Celia P. Corona-Villalobos (2794189), Ryuya Fukunaga (2794186), M. Roselle Abraham (242563), Junaid Afzal (2794192), Susan E. Liao (2794177), Yufan Guan (2794171), Zhaoxia Huo (2794183), Theodore P. Abraham (2794174)   +15 more
core   +1 more source

Extracellular Vesicles from NMN Preconditioned Mesenchymal Stem Cells Ameliorated Myocardial Infarction via miR-210-3p Promoted Angiogenesis. [PDF]

Stem Cell Rev Rep, 2023
Pu Y, Li C, Qi X, Xu R, Dong L, Jiang Y, Gong Q, Wang D, Cheng R, Zhang C, Chen Y.   +10 more
europepmc   +1 more source

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

Advanced Science, Volume 13, Issue 36, 29 June 2026.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang, Wenxuan Zhao, Xiaoming Hu, Yishu Wang, Peidong Yang, Diwei Zheng, Yugang Wang, Guanghui Ma, Min Shi, Wei Wei, Shuang Wang   +10 more
wiley   +1 more source

MiR-193a-3p inhibits pancreatic ductal adenocarcinoma cell proliferation by targeting CCND1

, 2019
Zhi-Min Chen,* Qiao Yu,* Gang Chen, Rui-Xue Tang, Dian-Zhong Luo, Yi-Wu Dang, Dan-Ming WeiDepartment of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning, People’s Republic of China*These authors contributed equally to ...
Dang YW, Luo DZ, Yu Q, Chen G, Wei DM, Chen ZM, Tang RX   +6 more
core  

Nucleic Acid Therapeutics for “Undruggable” Cancer Targets: Mechanisms, Challenges, and Prospects

Advanced Science, Volume 13, Issue 36, 29 June 2026.
Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Feng Xu, Ke Wang, Kaizhong Lu, Tianlun Hou, Yuan Chen, Xian Wang, Hongchuan Jin   +6 more
wiley   +1 more source

Vibronically Coupled Visible and Near‐Infrared Dual‐Band Emission From Te4+/Mo4+ Emitters in Cs2HfCl6

Aggregate, Volume 7, Issue 6, June 2026.
A Te4+ sensitization strategy is developed to achieve visible/near‐infrared dual‐band emission in Te4+/Mo4+ co‐doped Cs2HfCl6 with remarkable internal (91.8%) and external (81.0%) PLQYs. Direct evidence including well‐resolved vibrational fine emission structures and strong temperature‐dependent Te4+ PL lifetime is provided to unravel the PL origins ...
Wei Zhang, Wei Zheng, Junxiang Liu, Lingyun Li, Qingyi Liu, Ping Huang, Xiaoying Shang, Xiaolong Zheng, Yixuan Lu, Xueyuan Chen   +9 more
wiley   +1 more source