Results 101 to 110 of about 367,365 (231)

Seminal Plasma Exosomal miRNA Profiling Reveals hsa‐miR‐7‐5p as a Key Regulator of Sperm Motility in Asthenozoospermia

Andrology, EarlyView.
ABSTRACT Background Asthenozoospermia is a significant contributing factor to male infertility. Accumulating evidence indicates that impaired sperm motility is closely linked to dysregulated microRNA expression during spermatogenesis. Seminal plasma exosomes are enriched with diverse microRNAs, which play pivotal roles in modulating sperm motility, the
Zhi‐Jian Zhu, Meng‐Li Cui, Wen‐Jing Yuan, Jia‐Ning Zhang, Shuo Zhang, Xi‐Qiao Yao, Ruo‐Qing Li, Jin‐Feng Li, En‐Zhong Li   +8 more
wiley   +1 more source

Role and regulation of miR-483 in cancer

, 2012
The hsa-mir-483 locus is located at chromosome 11p15.5 within intron 2 of the IGF2 locus. Because of its location, de-regulated in Wilms’ tumor and other neoplasia, I hypothesized that this microRNA had a potential role in tumors.
Veronese, Angelo
core  

Ketogenic Diet Alleviates Colorectal Cancer by Attenuating Macrophage M2 Polarisation Triggered by Oncometabolite MMA Derived From the Gut Microbiota

Cell Proliferation, EarlyView.
Proposed mechanism of the ketogenic diet‐microbiota‐MMA‐immune axis in CRC. (Part 1) A ketogenic diet remodels gut microbiota homeostasis by depleting MMA‐producing bacteria, thereby reducing the accumulation of the oncometabolite (MMA). (Part 2) At the molecular level, MMA acts as a ligand that binds to Rap1, activating the downstream MAPK/ERK ...
Yang Lu, Bo Shi, Jinmiao Chen, Huihui Yao, Xiuwei Mi, Minke Shao, Yiyuan Zhao, Lijun Meng, Qingliang Tai, Junjie Chen, Xinyu Shi, Diyuan Zhou, Yizhou Yao, Songbing He   +13 more
wiley   +1 more source

Downregulation of RGMA by HIF-1A/miR-210-3p axis promotes cell proliferation in oral squamous cell carcinoma

Biomedicine & Pharmacotherapy, 2019
Repulsive guidance molecules comprise a group of proteins that play an important role in carcinogenesis through interactions with their receptors, but their function in oral squamous cell carcinoma (OSCC) is unclear. Here, we investigated the potential role of the RGM family members in oral cancer pathogenesis.
Yingjuan, Lu, Yingru, Li, Zhangsong, Wang, Shule, Xie, Qing, Wang, Xinyuan, Lei, Yi, Ruan, Jinsong, Li   +7 more
openaire   +2 more sources

Rôle de la boucle de régulation négative MUC4-miR-210-3p dans la cancérogenèse pancréatique et la chimio-résistance

, 2022
Background: Pancreatic adenocarcinoma (PDAC) is a deadly cancer with anextremely poor prognosis. MUC4 membrane-bound mucin is neoexpressed in earlypancreatic neoplastic lesions and is associated with PDAC progression andchemoresistance. In cancers, miRNA
Boukrout, Nihad
core  

Hyperthermia upregulates exosomal miR-210-3p to target GPD1L activating PI3K/AKT pathway and promoting atrial fibrosis

International Journal of Hyperthermia
Objective This study seeks to examine the role of miR-210-3p, delivered by atrial myocyte-derived exosomes, in the progression of atrial fibrosis after hyperthermia.Methods Firstly, by conducting a bioinformatics analysis on the miRDB, miRTarbase, and ...
Huixian Li, Feixing Li, Zhongbao Ruan
doaj   +1 more source

miR-29a-3p/T-bet Regulatory Circuit Is Altered in T Cells of Patients With Hashimoto’s Thyroiditis

Frontiers in Endocrinology, 2018
ObjectiveHashimoto’s thyroiditis (HT) is a common autoimmune thyroid disorder that frequently evolves from asymptomatic, T-cell mediated chronic inflammation toward overt hypothyroidism. Previously, we have demonstrated a role for T-bet, a T helper 1/CD8+
Stana Tokić, Stana Tokić, Mario Štefanić, Ljubica Glavaš-Obrovac, Amit Kishore, Zdenka Navratilova, Martin Petrek   +6 more
doaj   +1 more source

Unveiling Gut Homeostasis Disruption in Sepsis: Towards an Integrated Mechanistic and Translational Roadmap

Cell Proliferation, EarlyView.
Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao, Lin Qi, Guijun Zou, Xingpeng Yang, Yizhao Ma, Zhifu Li, Xiaohui Du, Pengyue Zhao   +7 more
wiley   +1 more source

MiR-497-5p, miR-195-5p and miR-455-3p function as tumor suppressors by targeting hTERT in melanoma A375 cells

, 2018
Li Chai,1 Xiao-Jing Kang,2 Zhen-Zhu Sun,3 Ming-Feng Zeng,2 Shi-Rong Yu,2 Yuan Ding,2 Jun-Qin Liang,2 Ting-Ting Li,2 Juan Zhao2 1Xinjiang Medical University, Urumqi, China; 2Department of Dermatology and Venereology, People’s Hospital of Xinjiang ...
Sun ZZ, Liang JQ, Chai L, Zeng MF, Ding Y, Kang XJ, Yu SR, Li TT, Zhao J   +8 more
core  

Longitudinal trajectory of circulating microRNA-210-3p and its association with low-dose aspirin use in gestational hypertension and preeclampsia: a pilot study

Clinical and Experimental Hypertension
Background Circulating microRNA-210-3p (miR-210-3p) is a hypoxia-related regulator implicated in placental maladaptation. Its longitudinal behavior across hypertensive disorders of pregnancy (HDP), and whether low-dose aspirin modifies its trajectory ...
Ming-Ju Wang, Chie-Pein Chen, Nan-Fu Chiu, Fang-Ju Sun, Hsin-Yi Hou, Chen-Yu Chen   +5 more
doaj   +1 more source