MicroRNAs and genes regulating responses to hypoxia and inflammation expression levels in blood leukocytes as potential biomarkers of initial oxygen deficiency tolerance [PDF]
Frontiers in Molecular BiosciencesIntroductionHypoxia-inducible factors (HIFs) play central roles in evoking responses to hypoxia, and their activities are regulated by numerous molecules, including microRNAs.
Maria Kirillova +9 more
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Serum miR-210-3p can be used to differentiate between patients with pancreatic ductal adenocarcinoma and chronic pancreatitis. [PDF]
Biomed Rep, 2021 Patients with chronic pancreatitis (CP) are at risk of developing pancreatic ductal adenocarcinoma (PDAC). To the best of our knowledge, there are no suitable non-invasive biomarkers for differentiation between CP and PDAC; however, potential molecular candidates include circulating miRNAs due to ease of extraction, their stability and tissue ...
Guz M +5 more
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Hypoxic colorectal cancer-secreted exosomes deliver miR-210-3p to normoxic tumor cells to elicit a protumoral effect. [PDF]
Exp Biol Med (Maywood), 2021 Hypoxia, the most common feature in the tumor microenvironment, is closely related to tumor malignant progression and poor patient’s prognosis. Exosomes, initially recognized as cellular “garbage dumpsters”, are now known to be important mediums for mediating cellular communication in tumor microenvironment.
Ge L, Zhou F, Nie J, Wang X, Zhao Q.
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Adipose extracellular vesicles carrying miR-210-3p drive macrophage inflammation and nicotine-induced atherosclerosis. [PDF]
iScienceLi Y +10 more
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, 2022 Under the condition of chronic obesity, an increased level of free fatty acids along with low oxygen tension in the adipose tissue creates a pathophysiological adipose tissue microenvironment (ATenv) leading to the impairment of adipocyte function and ...
Leena Arora (12966122) +11 more
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miR-210-3p regulates the proliferation and apoptosis of non-small cell lung cancer cells by targeting SIN3A. [PDF]
Exp Ther Med, 2019 Previous studies have indicated that microRNA (miR)-210-3p is upregulated in NSCLC, however, the specific mechanism underlying the role of miR-210-3p in NSCLC pathogenesis requires further investigation. The aim of the present study was to explore the roles of miR-210-3p in NSCLC and the associated mechanisms.
Ren J +6 more
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miR-22-3p regulates HCC cell EMT, migration, and invasion through the miR-22-3p-CBL-SPRY2 axis.
, 2023 A. Immunoblotting of CBL and SPRY2 in the three cell lines: HepG2 mock cells, HepG2 overexpressing miR-22-3p cells, and HepG2 overexpressing miR-22-3p plus CBL cells. B.
Dahu Chen (528122) +4 more
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Hypertension in Pregnancy, 2022 Objective The aim of this research was to explore the role and potential mechanism of long non-coding RNA PAXIP-AS1 in preeclampsia. Methods To investigate the effects of PAXIP-AS1 on cell viability, migration, and invasion.
Xuejuan Chen +5 more
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Lung CSC-derived exosomal miR-210-3p contributes to a pro-metastatic phenotype in lung cancer by targeting FGFRL1. [PDF]
J Cell Mol Med, 2020 AbstractLung cancer has the highest mortality rate among human cancers, and the majority of deaths can be attributed to metastatic spread. Lung cancer stem cells (CSCs) are a component of the tumour microenvironment that contributes to this process.
Wang L +6 more
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PLoS ONE, 2021 BackgroundGlioma is the most common and lethal form of brain cancer. It is highly malignant and is often characterized by chemoresistance and radioresistance, which are thought to mainly result from hypoxic microenvironments. Various tumour-promoting and
Hong Liu +4 more
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