Results 11 to 20 of about 367,365 (231)

Elevation of circulating miR-210-3p in high-altitude hypoxic environment [PDF]

Frontiers in Physiology, 2016
Background: The induction of miR-210-3p, a master hypoxamir, is a consistent feature of the hypoxic response in both normal and malignant cells. However, whether miR-210-3p acts as a circulating factor in response to a hypoxic environment remains unknown.
Yan eYan, Yan eYan, Cheng eWang, Cheng eWang, Wanqing eZhou, Yonghui eShi, Pengtao eGuo, Yuxiu eLiu, Junjun eWang, Chen-Yu eZhang, Chunni eZhang   +10 more
doaj   +6 more sources

Down-regulation of miR-210-3p encourages chemotherapy resistance of renal cell carcinoma via modulating ABCC1 [PDF]

Cell & Bioscience, 2018
Background ATP-binding cassette transporter super-family including ABCC1 and MDR-1 were involved in multi-drug resistance (MDR) of renal cell carcinoma (RCC) patients.
Songchao Li, Jinjian Yang, Jun Wang, Wansheng Gao, Yafei Ding, Yinghui Ding, Zhankui Jia   +6 more
doaj   +6 more sources

Overexpression of miR-210-3p Impairs Extravillous Trophoblast Functions Associated with Uterine Spiral Artery Remodeling [PDF]

International Journal of Molecular Sciences, 2021
Hsa-miR-210-3p has been reported to be upregulated in preeclampsia (PE); however, the functions of miR-210-3p in placental development are not fully understood, and, consequently, miR-210-3p’s role in the pathogenesis of PE is still under investigation. In this study, we found that overexpression of miR-210-3p reduced trophoblast migration and invasion,
Heyam Hayder, Guodong Fu, Lubna Nadeem   +2 more
exaly   +6 more sources

Expression of miR-210-3p as a Prognostic Marker for Development of Diabetic Neuropathy [PDF]

Metabolites
Background/Objectives: Diabetic neuropathy (DN) is one of the most common complications of type 2 diabetes mellitus (T2DM), involving complex metabolic, vascular, and epigenetic mechanisms. MicroRNA-210-3p (miR-210-3p), a hypoxia-responsive molecule, has
Savelia G. Yordanova, Diana Nikolova, Zdravko Kamenov, Vera Karamfilova, Traykov Lachezar, Yavor Assyov, Tsvetan Gatev, Radka Kaneva, Olga Belcheva, Darina Kachakova, Veronika Petkova, Yavor Zhelev, Antoaneta Trifonova Gateva   +12 more
doaj   +4 more sources

miR-210-3p enriched extracellular vesicles from hypoxic neuroblastoma cells stimulate migration and invasion of target cells [PDF]

Cell & Bioscience, 2023
Background Tumor hypoxia stimulates release of extracellular vesicles (EVs) that facilitate short- and long-range intercellular communication and metastatization. Albeit hypoxia and EVs release are known features of Neuroblastoma (NB), a metastasis-prone
Pina Fusco, Anna Fietta, Maria Rosaria Esposito, Luca Zanella, Sara Micheli, Angelica Bastianello, Lorenzo Bova, Giulia Borile, Giuseppe Germano, Elisa Cimetta   +9 more
doaj   +4 more sources

MiR-210-3p attenuates lipid accumulation and inflammation in atherosclerosis by repressing IGF2 [PDF]

Bioscience, Biotechnology, and Biochemistry, 2020
ABSTRACT Previous studies have shown that miR-210-3p is involved in the development and progression of atherosclerosis, but its specific mechanisms are still unclear. This study aims to reveal the mechanism of miR-210-3p and its target genes in macrophage lipid deposition and inflammatory response, and provide new ideas for the treatment
Xiang-Rui, Qiao, Liang, Wang, Mengping, Liu, Yuling, Tian, Tao, Chen   +4 more
openaire   +3 more sources

Antagonistic Roles of the Tumor Suppressor miR-210-3p and Oncomucin MUC4 Forming a Negative Feedback Loop in Pancreatic Adenocarcinoma. [PDF]

Cancers (Basel), 2021
Background: Pancreatic adenocarcinoma (PDAC) is a deadly cancer with an extremely poor prognosis. MUC4 membrane-bound mucin is neoexpressed in early pancreatic neoplastic lesions and is associated with PDAC progression and chemoresistance. In cancers, microRNAs (miRNAs, small noncoding RNAs) are crucial regulators of carcinogenesis, chemotherapy ...
Boukrout N, Souidi M, Lahdaoui F, Duchêne B, Neve B, Coppin L, Leteurtre E, Torrisani J, Van Seuningen I, Jonckheere N.   +9 more
europepmc   +6 more sources

Effects of miR-210-3p/SDF2 and miR-31-5p/FGF7 from hypoxic endometrial exosomes on UCB-MSC proliferation, migration, and differentiation [PDF]

Stem Cell Research & Therapy
Background Mesenchymal stem cells (MSCs) isolated from umbilical cord blood (UCB) exhibit significant therapeutic efficacy in endometriosis; however, the molecular mechanisms governing their regulation remain incompletely elucidated.
Simiao Liu, Wanyu Zhang, Chengyan Deng, Hanbi Wang   +3 more
doaj   +2 more sources

Oncogenic miR-210-3p promotes prostate cancer cell EMT and bone metastasis via NF-κB signaling pathway

Molecular Cancer, 2017
Background The primary issue arising from prostate cancer (PCa) is its high prevalence to metastasize to bone, which severely affects the quality of life and survival time of PCa patients.
Dong Ren, Qing Yang, Yuhu Dai, Wei Guo, Hong Du, Libing Song, Xinsheng Peng   +6 more
doaj   +2 more sources

Secreted miR-210-3p as non-invasive biomarker in clear cell renal cell carcinoma. [PDF]

Oncotarget, 2017
The most common subtype of renal cell carcinoma (RCC) is clear cell RCC (ccRCC). It accounts for 70-80% of all renal malignancies representing the third most common urological cancer after prostate and bladder cancer. The identification of non-invasive biomarkers for the diagnosis and responsiveness to therapy of ccRCC may represent a relevant step ...
Petrozza V, Pastore AL, Palleschi G, Tito C, Porta N, Ricci S, Marigliano C, Costantini M, Simone G, Di Carlo A, Gallucci M, Carbone A, Fazi F.   +12 more
europepmc   +6 more sources