MiR-543 Promotes Proliferation and Epithelial-Mesenchymal Transition in Prostate Cancer via Targeting RKIP [PDF]
Cellular Physiology and Biochemistry, 2017 Background/Aims: MicroRNAs (miRNAs, miRs) have emerged as important post-transcriptional regulators in various cancers. miR-543 has been reported to play critical roles in hepatocellular carcinoma and colorectal cancer, however, the role of miR-543 in ...
Yang Du +5 more
doaj +3 more sources
Roles of differential expression of miR-543-5p in GH regulation in rat anterior pituitary cells and GH3 cells. [PDF]
PLoS ONE, 2019 Growth hormone (GH) is an important hormone released by the pituitary gland that plays a key role in the growth and development of organisms. In our study, TargetScan analysis and the dual luciferase reporter assays were used to predict and screen for ...
Ze-Wen Yu +9 more
doaj +2 more sources
Dysregulation of miR-543 in Parkinson's disease: Impact on the neuroprotective gene SIRT1. [PDF]
Neuropathol Appl Neurobiol, 2023 Abstract Aims Parkinson's disease (PD) is a progressive and age‐dependent neurodegenerative disease characterised clinically by a variety of motor symptoms and cognitive impairment. PD was initially considered to be a grey matter disease; however, recently, evidence has emerged that white ...
Scheper M +5 more
europepmc +6 more sources
MiR-543/SNTB1 axis modulates immune microenvironment in colorectal cancer
陆军军医大学学报Objective To investigate the clinical significance of the miR-543/syntrophin beta 1 (SNTB1) axis in colorectal cancer (CRC) and its influence on the tumor immune microenvironment.
ZHANG Min, LI Min, XIAO Meng
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Upregulation of miR-370 and miR-543 is associated with reduced expression of heat shock protein 40 in spinocerebellar ataxia type 3. [PDF]
PLoS ONE, 2018 Molecular chaperones are important regulators of protein folding and proteasomal removal of misfolded proteins. In spinocerebellar ataxia type 3 (SCA3), the co-chaperone DnaJ homology subfamily B member 1 (DNAJB1 or heat shock protein 40) is recruited to
Bernd O Evert +9 more
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Expression of Regulatory Platelet MicroRNAs in Patients with Sickle Cell Disease [PDF]
, 2013 Background: Increased platelet activation in sickle cell disease (SCD) contributes to a state of hypercoagulability and confers a risk of thromboembolic complications.
A Abdollahi +71 more
core +19 more sources
miR-543 impairs breast cancer cell phenotypes by targeting and suppressing ubiquitin-conjugating enzyme E2T (UBE2T). [PDF]
Bioengineered, 2021 Breast cancer, with high morbidity worldwide, is a threat to the life of women. MiR-543 was identified as playing an active part in the development of breast cancer involving multiple molecules. The goal of this study was to explore the molecular mechanisms of the involvement of miR-543 in the development of breast cancer.
Li L, Li Q.
europepmc +4 more sources
Higher miR-543 levels correlate with lower STK31 expression and longer pancreatic cancer survival. [PDF]
Cancer Med, 2020 AbstractPancreatic cancer (PC) is one of the most malignant gastrointestinal tumors and the 5‐year survival is only 9%. The expression of miRNAs in serum has been proved to be related to tumorigenesis and development of cancers. The miRNA targets and gene targets were predicted in microRNA.org, miRDB, TargetScan, and RNAInter.
Yuan W +6 more
europepmc +4 more sources
LncRNA MEG3 inhibits the development of nasopharyngeal carcinoma by sponging miR-543 targeting KLF4. [PDF]
Transl Cancer Res, 2020 Emerging evidence shows that long non-coding RNAs (lncRNAs) play a crucial role in tumor development by regulating biological behavior in various cancer cells. Several lncRNAs act as miRNA sponges by binding miRNA sequences and thus regulating mRNA expression.
Ning J +5 more
europepmc +4 more sources
Circular RNA circARPP21 Acts as a Sponge of miR-543 to Suppress Hepatocellular Carcinoma by Regulating LIFR. [PDF]
Onco Targets Ther, 2021 A large body of evidence has shown that circular RNAs (circRNAs) play a significant role in the progression of some malignant cancers, including hepatocellular carcinoma (HCC). However, the complex mechanism of circRNAs in hepatocellular carcinoma has not been clarified.We identified circRNAs by microarray analysis and quantitative real-time polymerase
Gu Y +5 more
europepmc +5 more sources