MiR-543 promotes tumorigenesis and angiogenesis in non-small cell lung cancer via modulating metastasis associated protein 1 [PDF]
Molecular Medicine, 2020 Objective This study is aimed to explore the role of miR-543 in non-small cell lung cancer (NSCLC), and verify whether miR-543 targets metastasis associated protein 1 (MTA1) to affect tumorigenesis and angiogenesis in NSCLC.
Dawei Wang +3 more
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LncRNA MEG3 inhibits the development of nasopharyngeal carcinoma by sponging miR-543 targeting KLF4. [PDF]
Transl Cancer Res, 2020 Emerging evidence shows that long non-coding RNAs (lncRNAs) play a crucial role in tumor development by regulating biological behavior in various cancer cells. Several lncRNAs act as miRNA sponges by binding miRNA sequences and thus regulating mRNA expression.
Ning J +5 more
europepmc +5 more sources
m5C modification of LINC01082 inhibits osteosarcoma progression by modulating the miR-543-TNRC6A axis. [PDF]
Transl OncolHighlights • LINC01082 serves as a tumor-suppressive lncRNA in osteosarcoma (OS), with downregulated expression linked to poor prognosis.• 5-methylcytosine (m5C) modification stabilizes LINC01082 and enhances its tumor-suppressive effects, leading to ...
Hu Y +8 more
europepmc +4 more sources
Circular RNA FOXO3 accelerates glycolysis and improves cisplatin sensitivity in lung cancer cells via the miR-543/Foxo3 axis. [PDF]
Oncol Lett, 2021 Non-small cell lung cancer (NSCLC) is the most common cause of cancer-associated mortality worldwide. Our previous study revealed that circular RNA (circRNA)-FOXO3 is highly expressed in lung cancer and inhibits cell proliferation.
Zhang Y, Ge P, Zhou D, Xing R, Bai L.
europepmc +4 more sources
LncRNA PVT1 Regulates TRPS1 Expression in Breast Cancer by Sponging miR-543 [PDF]
Cancer Management and Research, 2020 Hongtao Wang,1,* Yuanli Huang,2,* Yuanrong Yang1 1Department of Pharmacy, The Second Clinical Medical College, Yangtze University, Jingzhou 434020, People’s Republic of China; 2Department of Galactophore, The Second Clinical Medical College ...
Wang H, Huang Y, Yang Y
doaj +4 more sources
miR-543 impairs breast cancer cell phenotypes by targeting and suppressing ubiquitin-conjugating enzyme E2T (UBE2T). [PDF]
Bioengineered, 2021 Breast cancer, with high morbidity worldwide, is a threat to the life of women. MiR-543 was identified as playing an active part in the development of breast cancer involving multiple molecules. The goal of this study was to explore the molecular mechanisms of the involvement of miR-543 in the development of breast cancer.
Li L, Li Q.
europepmc +5 more sources
Pathol Oncol Res, 2021 Intrauterine adhesion (IUA) is one of the most prevalent reproductive system diseases in females. MicroRNAs (miRNAs) are reported to be master regulators in a variety of diseases, including IUA, but the role of microRNA-543 (miR-543) in IUA remains to be
Wang L +7 more
europepmc +3 more sources
miR-543 promotes colorectal cancer proliferation and metastasis by targeting KLF4. [PDF]
Oncotarget, 2017 Till now, miR-543 expression has been demonstrated to be involved in the development of some cancers. However, reports about its expression and mechanism in colorectal cancer (CRC) were conflicting [1, 2]. Here, we investigated clinical implications of miR-543 and mechanisms underlying miR-543-mediated CRC development.
Zhai F, Cao C, Zhang L, Zhang J.
europepmc +5 more sources
LncRNA PCAT6 Accelerates the Progression and Chemoresistance of Cervical Cancer Through Up-Regulating ZEB1 by Sponging miR-543. [PDF]
Onco Targets Ther, 2020 Background Cervical cancer (CC) is a common cancer with a poor prognosis due to the chemoresistance of CC cells to cisplatin. This study aimed to investigate the biological significance of lncRNA prostate cancer-associated transcript 6 (PCAT6) in the ...
Ma Z, Gu G, Pan W, Chen X.
europepmc +4 more sources
Higher miR-543 levels correlate with lower STK31 expression and longer pancreatic cancer survival. [PDF]
Cancer Med, 2020 AbstractPancreatic cancer (PC) is one of the most malignant gastrointestinal tumors and the 5‐year survival is only 9%. The expression of miRNAs in serum has been proved to be related to tumorigenesis and development of cancers. The miRNA targets and gene targets were predicted in microRNA.org, miRDB, TargetScan, and RNAInter.
Yuan W +6 more
europepmc +5 more sources