Overview on population screening for carriers with germline mutations in mismatch repair (MMR) genes in China [PDF]
Hereditary Cancer in Clinical Practice, 2021 DNA mismatch repair (MMR) genes play an important role in maintaining genome stability. Germline mutations in MMR genes disrupt the mismatch repair function and cause genome instability.
Min Zhang, Tianhui Chen
doaj +2 more sources
High-resolution mapping of heteroduplex DNA formed during UV-induced and spontaneous mitotic recombination events in yeast [PDF]
eLife, 2017 In yeast, DNA breaks are usually repaired by homologous recombination (HR). An early step for HR pathways is formation of a heteroduplex, in which a single-strand from the broken DNA molecule pairs with a strand derived from an intact DNA molecule.
Yi Yin +3 more
doaj +5 more sources
An
mBio, 2013 Enteropathogenic Escherichia coli (EPEC) is an attaching and effacing (A/E) human pathogen that causes diarrhea during acute infection, and it can also sustain asymptomatic colonization. A/E E.
Oliver David Kenneth Maddocks +2 more
doaj +3 more sources
The intersection of homologous recombination (HR) and mismatch repair (MMR) pathways in DNA repair-defective tumors [PDF]
npj Precision OncologyHomologous recombination (HR) and mismatch repair (MMR) defects are driver mutational imprints and actionable biomarkers in DNA repair-defective tumors.
Lorena Incorvaia +17 more
doaj +2 more sources
Mismatch Repair (MMR) Gene Alteration and BRAF V600E Mutation Are Potential Predictive Biomarkers of Immune Checkpoint Inhibitors in MMR-Deficient Colorectal Cancer [PDF]
Oncologist, 2021 Ibrahim Halil Sahin +2 more
exaly +2 more sources
Heterogenous loss of mismatch repair (MMR) protein expression: a challenge for immunohistochemical interpretation and microsatellite instability (MSI) evaluation [PDF]
Journal of Pathology: Clinical Research, 2019 Aoife J Mccarthy +2 more
exaly +2 more sources
Pms2 suppresses large expansions of the (GAA·TTC)n sequence in neuronal tissues [PDF]
, 2012 Copyright @ 2012 Bourn et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source ...
Chiranjeevi Sandi +7 more
core +20 more sources
An inducible, isogenic cancer cell line system for targeting the state of mismatch repair deficiency. [PDF]
PLoS ONE, 2013 The DNA mismatch repair system (MMR) maintains genome stability through recognition and repair of single-base mismatches and small insertion-deletion loops. Inactivation of the MMR pathway causes microsatellite instability and the accumulation of genomic
Julie M Bailis +5 more
doaj +1 more source
Zhongliu Fangzhi Yanjiu, 2021 Objective To investigate the clinicopathological characteristics of colon cancer patients with different mismatch repair gene (MMR) status and evaluate the value of MMR status combined with preoperative blood neutrophil-lymphocyte ratio (NLR) in ...
CHEN Ping +4 more
doaj +1 more source
Mutational spectrum of DNA damage and mismatch repair genes in prostate cancer
Frontiers in Genetics, 2023 Over the past few years, a number of studies have revealed that a significant number of men with prostate cancer had genetic defects in the DNA damage repair gene response and mismatch repair genes.
Fidelis Charles Bugoye +7 more
doaj +1 more source