Results 41 to 50 of about 337,835 (308)
Distinct Mechanisms of Pathogenic DJ-1 Mutations in Mitochondrial Quality Control [PDF]
, 2018 The deglycase and chaperone protein DJ-1 is pivotal for cellular oxidative stress responses and mitochondrial quality control. Mutations in PARK7, encoding DJ-1, are associated with early-onset familial Parkinson’s disease and lead to pathological ...
Abeti +66 more
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Complex oscillatory redox dynamics with signaling potential at the edge between normal and pathological mitochondrial function [PDF]
, 2014 The time-keeping properties bestowed by oscillatory behavior on functional rhythms represent an evolutionarily conserved trait in living systems. Mitochondrial networks function as timekeepers maximizing energetic output while tuning reactive oxygen ...
Aon, Miguel A. +2 more
core +2 more sources
Research in Cardiovascular Medicine, 2018 Mitochondria as dynamic organelle constantly undergo fusion and fission reactions, leading to continuous reconstruction of the mitochondrial network for elongated or fragmentation shapes and ultimately the mitophagy.
Babak Ebadi +4 more
doaj +1 more source
Role of Mitochondrial Dynamics in Neuronal Development: Mechanism for Wolfram Syndrome. [PDF]
PLoS Biology, 2016 Deficiency of the protein Wolfram syndrome 1 (WFS1) is associated with multiple neurological and psychiatric abnormalities similar to those observed in pathologies showing alterations in mitochondrial dynamics.
Michal Cagalinec +12 more
doaj +1 more source
Defective mitochondrial dynamics is an early event in skeletal muscle of an amyotrophic lateral sclerosis mouse model. [PDF]
PLoS ONE, 2013 Mitochondria are dynamic organelles that constantly undergo fusion and fission to maintain their normal functionality. Impairment of mitochondrial dynamics is implicated in various neurodegenerative disorders.
Guo Luo +6 more
doaj +1 more source
Chronic heart failure is characterized by altered mitochondrial function and structure in circulating leucocytes [PDF]
, 2018 Oxidative stress is currently viewed as a key factor in the genesis and progression of Heart Failure (HF). The aim of this study was to characterize the mitochondrial changes linked to oxidative stress generation in circulating peripheral blood ...
Coluccia, Roberta +12 more
core +1 more source
Mitochondrial Dynamics in Pulmonary Hypertension
Biomedicines, 2023 Mitochondria are essential organelles for energy production, calcium homeostasis, redox signaling, and other cellular responses involved in pulmonary vascular biology and disease processes. Mitochondrial homeostasis depends on a balance in mitochondrial fusion and fission (dynamics).
Ed Wilson Santos +4 more
openaire +5 more sources
Structural basis of mitochondrial receptor binding and constriction by DRP1. [PDF]
, 2018 Mitochondrial inheritance, genome maintenance and metabolic adaptation depend on organelle fission by dynamin-related protein 1 (DRP1) and its mitochondrial receptors. DRP1 receptors include the paralogues mitochondrial dynamics proteins of 49 and 51 kDa
Agard, David A +6 more
core +1 more source
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2006 Higher plant mitochondria are dynamic, pleomorphic organelles. The higher plant chondriome (all mitochondria in a cell collectively) is typically composed of numerous, physically discrete, mitochondria. However, frequent inter-mitochondrial fusion, enabling the mixing and recombination of mtDNA, ensures that the higher plant chondriome functions, at ...
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Mitochondrial dynamics and neurodegeneration [PDF]
Current Neurology and Neuroscience Reports, 2009 Mitochondria are key organelles in eukaryotic cells that not only generate adenosine triphosphate but also perform such critical functions as hosting essential biosynthetic pathways, calcium buffering, and apoptotic signaling. In vivo, mitochondria form dynamic networks that undergo frequent morphologic changes through fission and fusion.
openaire +2 more sources