Mitochondrial dysfunction and mitochondrial dynamics-The cancer connection
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2017 Mitochondrial dysfunction is a hallmark of many diseases. The retrograde signaling initiated by dysfunctional mitochondria can bring about global changes in gene expression that alters cell morphology and function. Typically, this is attributed to disruption of important mitochondrial functions, such as ATP production, integration of metabolism ...
Satish, Srinivasan +3 more
openaire +2 more sources
Redox Homeostasis and Mitochondrial Dynamics [PDF]
Cell Metabolism, 2015 Within living cells, mitochondria are considered relevant sources of reactive oxygen species (ROS) and are exposed to reactive nitrogen species (RNS). During the last decade, accumulating evidence suggests that mitochondrial (dys)function, ROS/RNS levels, and aberrations in mitochondrial morphology are interconnected, albeit in a cell- and context ...
Willems, P.H.G.M. +4 more
openaire +3 more sources
Mitochondrial fission regulates germ cell differentiation by suppressing ROS-mediated activation of Epidermal Growth Factor Signaling in the Drosophila larval testis. [PDF]
, 2019 Mitochondria are essential organelles that have recently emerged as hubs for several metabolic and signaling pathways in the cell. Mitochondrial morphology is regulated by constant fusion and fission events to maintain a functional mitochondrial network ...
Jones, D Leanne, Sênos Demarco, Rafael
core +1 more source
αSynuclein control of mitochondrial homeostasis in human-derived neurons is disrupted by mutations associated with Parkinson’s disease [PDF]
, 2017 The etiology of Parkinson’s disease (PD) converges on a common pathogenic pathway of mitochondrial defects in which α-Synuclein (αSyn) is thought to play a role.
Alloatti, Matías +12 more
core +1 more source
To unite or divide: mitochondrial dynamics in the murine outer retina that preceded age related photoreceptor loss [PDF]
, 2015 Mitochondrial function declines with age and is associated with age-related disorders and cell death. In the retina this is critical as photoreceptor energy demands are the greatest in the body and aged cell loss large (~30%).
Jeffery, G, Kam, JH
core +2 more sources
Mitochondrial Dynamics at the Interface of Immune Cell Metabolism and Function
, 2018 Immune cell differentiation and function are crucially dependent on specific metabolic programs dictated by mitochondria, including the generation of ATP from the oxidation of nutrients and supplying precursors for the synthesis of macromolecules and ...
Pearce, E., Rambold, A.
core +1 more source
The Interplay among PINK1/PARKIN/Dj-1 Network during Mitochondrial Quality Control in Cancer Biology: Protein Interaction Analysis [PDF]
, 2018 PARKIN (E3 ubiquitin ligase PARK2), PINK1 (PTEN induced kinase 1) and DJ-1 (PARK7) are proteins involved in autosomal recessive parkinsonism, and carcinogenic processes.
Lucas, Millikin, Narendra, Santel, Zhang
core +2 more sources
Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development [PDF]
, 2003 Mitochondrial morphology is determined by a dynamic equilibrium between organelle fusion and fission, but the significance of these processes in vertebrates is unknown.
Chan, David C. +5 more
core +2 more sources
The PINK1/Parkin pathway: a mitochondrial quality control system? [PDF]
, 2009 Significant insight into the mechanisms that contribute to dopaminergic neurodegeneration in Parkinson disease has been gained from the analysis of genes linked to rare heritable forms of parkinsonism such as PINK1 and parkin, loss-of-function mutations ...
Pallanck, L.J., Whitworth, A.J.
core +1 more source
The Stat3-Fam3a axis promotes muscle stem cell myogenic lineage progression by inducing mitochondrial respiration. [PDF]
, 2019 Metabolic reprogramming is an active regulator of stem cell fate choices, and successful stem cell differentiation in different compartments requires the induction of oxidative phosphorylation.
Cunningham, Thomas J +9 more
core +3 more sources