Results 51 to 60 of about 1,859,766 (381)

Bench-to-bedside review : targeting antioxidants to mitochondria in sepsis [PDF]

, 2010
Peer reviewedPublisher ...
A Dhanasekaran, A Dyson, A Filipovska, AL Hill, AM James, B Bedogni, BE Minter, CA Macias, CC Chuang, CE Cross, D Brealey, D Brealey, D Brealey, D Graham, DA Lowes, DA Lowes, DP Jones, E Borrelli, ED Crouser, ED Crouser, F Arnalich, FN Gellerich, G Escames, G Escames, GF Kelso, GS Supinski, H Bayir, H Bohrer, H Zhang, HC Cowley, Helen F Galley, HF Galley, HF Galley, HF Galley, HF Goode, I Spasojević, I Vanhorebeek, J Ripcke, JC Marshall, JF Turrens, JJ Pandit, JV Esplugues, K Yassen, K Zhao, KS Roser, L Packer, M Qunitero, MD Wheeler, MD Wheeler, MP Fink, MP Fink, MP Murphy, MW Fariss, P Ghafourifar, P Wipf, RAJ Smith, RAJ Smith, RL Paterson, RO Poyton, S González-Rubio, S Rinaldi, SS Sheu, V Mishra, V Vanasco, VJ Adlam, VP Skulachev, W Droge, Z Lacza   +67 more
core   +2 more sources

Peroxynitrite-Mediated Mitochondrial Dysfunction

Neurosignals, 2001
Peroxynitrite anion (ONOO(-)) is a potent biological oxidant produced by the near diffusion-limited reaction of superoxide and nitric oxide. Peroxynitrite has been implicated in diverse forms of free radical-induced tissue injury. Experimental evidence showed that exogenous and endogenous peroxynitrite causes alterations of the structure and function ...
J, Boczkowski, C L, Lisdero, S, Lanone, M C, Carreras, M, Aubier, J J, Poderoso   +5 more
openaire   +2 more sources

Mitochondrial Dysfunction Accelerates Ageing

Immunometabolism, 2020
Abstract We review here the seminal findings of Desdin-Mico et al. showing that T cells with dysfunctional mitochondria induce multimorbity and premature senescence, due to mitochondrial transcription factor A (TFAM). They add further weight to the idea that targeting immunometabolism could be beneficial in combating the ...
Schroth, J, Henson, SM
openaire   +3 more sources

Hormone deprivation alters mitochondrial function and lipid profile in the hippocampus [PDF]

, 2017
Mitochondrial dysfunction is a common hallmark in aging. In the female, reproductive senescence is characterized by loss of ovarian hormones, many of whose neuroprotective effects converge upon mitochondria.
Alvarez, Silvia, Astiz, Mariana, Imsen, Mercedes, Magnani, Natalia Daniela, Merino, Florencia, Reines, Analia Gabriela, Seilicovich, Adriana, Zarate, Sandra Cristina   +7 more
core   +2 more sources

Mitochondrial dysfunction in obesity [PDF]

Current Opinion in Endocrinology, Diabetes and Obesity, 2010
The review highlights recent findings regarding the functions of mitochondria in adipocytes, providing an understanding of their central roles in regulating substrate metabolism, energy expenditure, disposal of reactive oxygen species (ROS), and in the pathophysiology of obesity and insulin resistance, as well as roles in the mechanisms that affect ...
Juan C, Bournat, Chester W, Brown
openaire   +2 more sources

Loss of mitochondrial transcription factor A in neural stem cells leads to immature brain development and triggers the activation of the integral stress response in vivo.

PLoS ONE, 2021
Mitochondrial dysfunction is significantly associated with neurological deficits and age-related neurological diseases. While mitochondria are dynamically regulated and properly maintained during neurogenesis, the manner in which mitochondrial activities
Rintaro Kuroda, Kaoru Tominaga, Katsumi Kasashima, Kenji Kuroiwa, Eiji Sakashita, Hiroko Hayakawa, Tom Kouki, Nobuhiko Ohno, Kensuke Kawai, Hitoshi Endo   +9 more
doaj   +1 more source

Brief report: High frequency of biochemical markers for mitochondrial dysfunction in autism: no association with the mitochondrial aspartate/glutamate carrier SLC25A12 gene [PDF]

, 2006
In the present study we confirm the previously reported high frequency of biochemical markers of mitochondrial dysfunction, namely hyperlactacidemia and increased lactate/pyruvate ratio, in a significant fraction of 210 autistic patients.
Almeida, J., Ataíde, A., Borges, L., Correia, C., Coutinho, A.M., Diogo, L., Grazina, M., Marques, C., Miguel, T., Oliveira, C., Oliveira, G., Vicente, A.M.   +11 more
core   +1 more source

Altered Cardiac Energetics and Mitochondrial Dysfunction in Hypertrophic Cardiomyopathy

Circulation, 2021
Supplemental Digital Content is available in the text. Background: Hypertrophic cardiomyopathy (HCM) is a complex disease partly explained by the effects of individual gene variants on sarcomeric protein biomechanics. At the cellular level, HCM mutations
Sara Ranjbarvaziri, K. Kooiker, M. Ellenberger, G. Fajardo, Mingming Zhao, A. V. Vander Roest, R. A. Woldeyes, Tiffany T Koyano, R. Fong, Ning Ma, Lei Tian, G. Traber, F. Chan, J. Perrino, Sushma Reddy, Wah Chiu, Joseph C. Wu, Joseph Y. Woo, K. Ruppel, J. Spudich, M. Snyder, K. Contrepois, D. Bernstein   +22 more
semanticscholar   +1 more source

Potential therapeutic use of the ketogenic diet in autism spectrum disorders. [PDF]

, 2014
The ketogenic diet (KGD) has been recognized as an effective treatment for individuals with glucose transporter 1 (GLUT1) and pyruvate dehydrogenase (PDH) deficiencies as well as with epilepsy.
Dueñas, Nadia, Giulivi, Cecilia, Napoli, Eleonora   +2 more
core   +1 more source

Mitochondrial Dysfunction in Cancer [PDF]

Frontiers in Oncology, 2013
A mechanistic understanding of how mitochondrial dysfunction contributes to cell growth and tumorigenesis is emerging beyond Warburg as an area of research that is under-explored in terms of its significance for clinical management of cancer. Work discussed in this review focuses less on the Warburg effect and more on mitochondria and how dysfunctional
Boland, Michelle L., Chourasia, Aparajita H., Macleod, Kay F.   +2 more
openaire   +3 more sources