Results 11 to 20 of about 41,598 (256)

Mitochondrial fission and fusion [PDF]

Essays in Biochemistry, 2010
Mitochondria are highly dynamic cellular organelles, with the ability to change size, shape and position over the course of a few seconds. Many of these changes are related to the ability of mitochondria to undergo the highly co-ordinated processes of fission (division of a single organelle into two or more independent structures) or fusion (the ...
Iain, Scott, Richard J, Youle
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Mitochondrial fusion, fission, and mitochondrial toxicity [PDF]

Toxicology, 2017
Mitochondrial dynamics are regulated by two sets of opposed processes: mitochondrial fusion and fission, and mitochondrial biogenesis and degradation (including mitophagy), as well as processes such as intracellular transport. These processes maintain mitochondrial homeostasis, regulate mitochondrial form, volume and function, and are increasingly ...
Joel N, Meyer, Tess C, Leuthner, Anthony L, Luz   +2 more
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Mitochondrial membrane tension governs fission [PDF]

Cell Reports, 2018
Abstract During mitochondrial fission, key molecular and cellular factors assemble on the outer mitochondrial membrane, where they coordinate to generate constriction. Constriction sites can eventually divide, or reverse upon disassembly of the machinery. However, a role for membrane tension in mitochondrial fission, although speculated,
Mahecic, Dora, Carlini, Lina, Kleele, Tatjana, Colom Diego, Adai, Goujon, Antoine, Matile, Stefan, Roux, Aurélien, Manley, Suliana   +7 more
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Elastocapillary Instability in Mitochondrial Fission [PDF]

Physical Review Letters, 2015
Mitochondria are dynamic cell organelles that constantly undergo fission and fusion events. These dynamical processes, which tightly regulate mitochondrial morphology, are essential for cell physiology. Here we propose an elastocapillary mechanical instability as a mechanism for mitochondrial fission.
Gonzalez-Rodriguez, David, Sart, Sébastien, Babataheri, Avin, Tareste, David, Barakat, Abdul, Clanet, Christophe, Husson, Julien   +6 more
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Mitochondrial Fission, Fusion, and Stress [PDF]

Science, 2012
Mitochondrial Dynamics Mitochondria—the powerhouses of the cell—are autonomous organelles with their own genomes. Within cells, mitochondria are remarkably dynamic, continually moving around the cytoplasm and undergoing fusion and fission reactions. Youle and van der Bliek (p. 1062 )
Richard J, Youle, Alexander M, van der Bliek   +1 more
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Mitochondrial fission factor (MFF) frameshift variant in Bullmastiffs with mitochondrial fission encephalopathy

Animal Genetics, 2022
AbstractFamilial cerebellar ataxia with hydrocephalus in Bullmastiffs was described almost 40 years ago as a monogenic autosomal recessive trait. We investigated two young Bullmastiffs showing similar clinical signs. They developed progressive gait and behavioural abnormalities with an onset at around 6 months of age.
Matthias Christen, Rodrigo Gutierrez‐Quintana, Helene Vandenberghe, Adriana Kaczmarska, Jacques Penderis, Roberto José‐López, Angie Rupp, Ian R. Griffiths, Vidhya Jagannathan, Tosso Leeb   +9 more
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Enhanced mitochondrial fission suppresses signaling and metastasis in triple-negative breast cancer

Breast Cancer Research, 2020
Background Mitochondrial dynamics underlies malignant transformation, cancer progression, and response to treatment. Current research presents conflicting evidence for functions of mitochondrial fission and fusion in tumor progression.
Brock A. Humphries, Alyssa C. Cutter, Johanna M. Buschhaus, Yu-Chih Chen, Tonela Qyli, Dilrukshika S. W. Palagama, Samantha Eckley, Tanner H. Robison, Avinash Bevoor, Benjamin Chiang, Henry R. Haley, Saswat Sahoo, Phillip C. Spinosa, Dylan B. Neale, Jagadish Boppisetti, Debashis Sahoo, Pradipta Ghosh, Joerg Lahann, Brian D. Ross, Eusik Yoon, Kathryn E. Luker, Gary D. Luker   +21 more
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Mitochondrial morphological features are associated with fission and fusion events. [PDF]

PLoS ONE, 2014
Mitochondria are dynamic organelles that undergo constant remodeling through the regulation of two opposing processes, mitochondrial fission and fusion.
Laura M Westrate, Jeffrey A Drocco, Katie R Martin, William S Hlavacek, Jeffrey P MacKeigan   +4 more
doaj   +1 more source

The Role of Mitochondrial Dynamics and Mitotic Fission in Regulating the Cell Cycle in Cancer and Pulmonary Arterial Hypertension: Implications for Dynamin-Related Protein 1 and Mitofusin2 in Hyperproliferative Diseases

Cells, 2023
Mitochondria, which generate ATP through aerobic respiration, also have important noncanonical functions. Mitochondria are dynamic organelles, that engage in fission (division), fusion (joining) and translocation. They also regulate intracellular calcium
Pierce Colpman, Asish Dasgupta, Stephen L. Archer   +2 more
doaj   +1 more source

Overproduction of Mitochondrial Fission Proteins and Mitochondrial Fission in Podocytes of Lupus Nephritis Patients. [PDF]

J Inflamm Res
The glomerular injury is associated with different pathogeneses, and podocyte damage is common in various ISN/RPS class lupus nephritis (LN). In podocyte, mitochondrial morphological changes are observed in lupus nephritis (LN) in our previous study. This study aimed to explore mitochondrial fission proteins expression in podocytes using bioinformatics
Wei Q, Wu X, Chen Z, Lin H, Xiong L, Wang N.   +5 more
europepmc   +3 more sources