Results 21 to 30 of about 41,598 (256)

miR-30 regulates mitochondrial fission through targeting p53 and the dynamin-related protein-1 pathway.

PLoS Genetics, 2010
miRNAs participate in the regulation of apoptosis. However, it remains largely unknown as to how miRNAs are integrated into the apoptotic program. Mitochondrial fission is involved in the initiation of apoptosis.
Jincheng Li, Stefan Donath, Yanrui Li, Danian Qin, Bellur S Prabhakar, Peifeng Li   +5 more
doaj   +1 more source

Enhanced mitochondrial fission inhibits triple-negative breast cancer cell migration through an ROS-dependent mechanism

iScience, 2023
Summary: Mitochondria produce reactive oxygen species (ROS), which function in signal transduction. Mitochondrial dynamics, encompassing morphological shifts between fission and fusion, can directly impact ROS levels in cancer cells.
Brock A. Humphries, Anne Zhang, Johanna M. Buschhaus, Avinash Bevoor, Alex Farfel, Shrila Rajendran, Alyssa C. Cutter, Gary D. Luker   +7 more
doaj   +1 more source

Tanshinone IIA reduces SW837 colorectal cancer cell viability via the promotion of mitochondrial fission by activating JNK-Mff signaling pathways

BMC Cell Biology, 2018
Background Mitochondrial homeostasis has been increasingly viewed as a potential target of cancer therapy, and mitochondrial fission is a novel regulator of mitochondrial function and apoptosis.
Sayilaxi Jieensinue, Hong Zhu, Guangcheng Li, Keli Dong, Meiting Liang, Yayue Li   +5 more
doaj   +1 more source

Activation of ERK–Drp1 signaling promotes hypoxia‐induced Aβ accumulation by upregulating mitochondrial fission and BACE1 activity

FEBS Open Bio, 2021
Hypoxia is a risk factor for Alzheimer's disease (AD). Besides, mitochondrial fission is increased in response to hypoxia. In this study, we sought to investigate whether hypoxia‐induced mitochondrial fission plays a critical role in regulating amyloid‐β
Yuan Yuan, Jingjiong Chen, Xuhua Ge, Jiangshan Deng, Xiaofeng Xu, Yuwu Zhao, Hongmei Wang   +6 more
doaj   +1 more source

Mitochondrial Fission in Human Diseases [PDF]

, 2016
Mitochondria are an essential component of multicellular life - from primitive organisms, to highly complex entities like mammals. The importance of mitochondria is underlined by their plethora of well-characterized essential functions such as energy production through oxidative phosphorylation (OX-PHOS), calcium and reactive oxygen species (ROS ...
Madhavika N, Serasinghe, Jerry E, Chipuk
openaire   +2 more sources

Atypical mitochondrial fission upon bacterial infection [PDF]

Proceedings of the National Academy of Sciences, 2013
Significance Mitochondria are dynamic organelles that constantly fuse and fragment while acting as central hubs of energy production, apoptosis regulation, and Ca ++ signaling, therefore emerging as potential targets of pathogens.
Stavru, Fabrizia, Palmer, Amy E., Wang, Chunxin, Youle, Richard J., Cossart, Pascale   +4 more
openaire   +4 more sources

Mitochondrial Fission Is Required for Angiotensin II-Induced Cardiomyocyte Apoptosis Mediated by a Sirt1-p53 Signaling Pathway

Frontiers in Pharmacology, 2018
Hypertension-induced cardiac apoptosis is a major contributor to early-stage heart-failure. Our previous studies have found that p53-mediated mitochondrial fission is involved in aldosterone-induced podocyte apoptosis.
Jia Qi, Jia Qi, Feng Wang, Ping Yang, Xuelian Wang, Renjie Xu, Jihui Chen, Yanggang Yuan, Zhaoyang Lu, Zhaoyang Lu, Junli Duan   +10 more
doaj   +1 more source

Aberrant Mitochondrial Fission Is Maladaptive in Desmin Mutation–Induced Cardiac Proteotoxicity

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background Desmin filament proteins interlink the contractile myofibrillar apparatus with mitochondria, nuclei and the sarcolemma. Mutations in the human desmin gene cause cardiac disease, remodeling, and heart failure but the pathophysiological ...
Shafiul Alam, Chowdhury S. Abdullah, Richa Aishwarya, Sumitra Miriyala, Manikandan Panchatcharam, Jonette M. Peretik, A. Wayne Orr, Jeanne James, Jeffrey Robbins, Md. Shenuarin Bhuiyan   +9 more
doaj   +1 more source

ROCK1 activation-mediated mitochondrial translocation of Drp1 and cofilin are required for arnidiol-induced mitochondrial fission and apoptosis

Journal of Experimental & Clinical Cancer Research, 2020
Background Arnidiol is a pentacyclic triterpene diol that has multiple pharmacological activities. However, the apoptotic activities of arnidiol in human cancer cells have not yet been explored, nor has the mechanism by which arnidiol induces apoptosis ...
Jinjiao Hu, Hongwei Zhang, Jie Li, Xiuxing Jiang, Yanhao Zhang, Qin Wu, liwen Shen, Jingshan Shi, Ning Gao   +8 more
doaj   +1 more source

Preventing mitochondrial fission impairs mitochondrial function and leads to loss of mitochondrial DNA. [PDF]

PLoS ONE, 2008
Mitochondria form a highly dynamic tubular network, the morphology of which is regulated by frequent fission and fusion events. However, the role of mitochondrial fission in homeostasis of the organelle is still unknown.
Philippe A Parone, Sandrine Da Cruz, Daniel Tondera, Yves Mattenberger, Dominic I James, Pierre Maechler, François Barja, Jean-Claude Martinou   +7 more
doaj   +1 more source